首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   2847篇
  免费   112篇
  国内免费   40篇
化学   1741篇
晶体学   37篇
力学   75篇
数学   526篇
物理学   620篇
  2023年   24篇
  2022年   28篇
  2021年   62篇
  2020年   67篇
  2019年   61篇
  2018年   37篇
  2017年   40篇
  2016年   80篇
  2015年   61篇
  2014年   80篇
  2013年   155篇
  2012年   213篇
  2011年   210篇
  2010年   124篇
  2009年   99篇
  2008年   150篇
  2007年   135篇
  2006年   146篇
  2005年   124篇
  2004年   118篇
  2003年   96篇
  2002年   79篇
  2001年   53篇
  2000年   59篇
  1999年   50篇
  1998年   27篇
  1997年   47篇
  1996年   28篇
  1995年   38篇
  1994年   36篇
  1993年   42篇
  1992年   48篇
  1991年   37篇
  1990年   34篇
  1989年   31篇
  1988年   17篇
  1987年   19篇
  1986年   20篇
  1985年   31篇
  1984年   23篇
  1983年   8篇
  1982年   17篇
  1981年   15篇
  1980年   9篇
  1979年   18篇
  1978年   16篇
  1977年   8篇
  1975年   6篇
  1974年   12篇
  1973年   10篇
排序方式: 共有2999条查询结果,搜索用时 15 毫秒
1.
miRNA (miR)-155 is a potential biomarker for breast cancers. We aimed at developing a nanosensor for miR-155 detection by integrating hybridization chain reaction (HCR) and silver nanoclusters (AgNCs). HCR serves as an enzyme-free and isothermal amplification method, whereas AgNCs provide a built-in fluorogenic detection probe that could simplify the downstream analysis. The two components were integrated by adding a nucleation sequence of AgNCs to the hairpin of HCR. The working principle was based on the influence of microenvironment towards the hosted AgNCs, whereby unfolding of hairpin upon HCR has manipulated the distance between the hosted AgNCs and cytosine-rich toehold region of hairpin. As such, the dominant emission of AgNCs changed from red to yellow in the absence and presence of miR-155, enabling a ratiometric measurement of miR with high sensitivity. The limit of detection (LOD) of our HCR-AgNCs nanosensor is 1.13 fM in buffered solution. We have also tested the assay in diluted serum samples, with comparable LOD of 1.58 fM obtained. This shows the great promise of our HCR-AgNCs nanosensor for clinical application.  相似文献   
2.
3.
The natural modes of a discrete linear system are orthogonal with respect to the mass and stiffness matrices in a generalized sense. However, these modes are usually not orthogonal to each other in the ordinary sense. The purpose of this paper is to document a number of conditions under which the modes are also orthogonal in an ordinary fashion.  相似文献   
4.
Siaw-Lynn Ng 《Order》2004,21(1):1-5
We present a characterisation of posets of size n with linear discrepancy n − 2. These are the posets that are “furthest” from a linear order without being an antichain. This revised version was published online in September 2006 with corrections to the Cover Date.  相似文献   
5.
We will prove a result concerning the inclusion of non-trivial invariant ideals inside non-trivial ideals of a twisted crossed product. We will also give results concerning the primeness and simplicity of crossed products of twisted actions of locally compact groups on -algebras. Received: 25 January 2002; in final form: 22 May 2002/Published online: 2 December 2002 This work is partially supported by Hong Kong RGC Direct Grant.  相似文献   
6.
Molecular dynamics simulations have been carried out for small water clusters (N=16, 32, 64) in a d.c. electric field at T=200 K. It was shown that for relatively weak fields, there was a significant decrease of reorientational and structural relaxation times for all cluster sizes examined. Regarding the molecular reorientational motions, in the strong field regime, a decoupling of tumbling and spinning librations was observed. Reorientational relaxation times of the dipole and vector joining the two hydrogen atoms were found to follow different relaxation laws, with the former decreasing and the latter increasing with electric field increase. These trends were qualitatively explained by invoking the Debye model with field-dependent friction for dipole librations and the symmetric double-well for spinning rotations on a plane perpendicular to the field axis. Finally, the interdependence of the reorientation on the translational modes of the cluster was indicated, with the translationally slow molecules being rotationally slow as well and vice versa.  相似文献   
7.
A novel method, entitled the discrete global descent method, is developed in this paper to solve discrete global optimization problems and nonlinear integer programming problems. This method moves from one discrete minimizer of the objective function f to another better one at each iteration with the help of an auxiliary function, entitled the discrete global descent function. The discrete global descent function guarantees that its discrete minimizers coincide with the better discrete minimizers of f under some standard assumptions. This property also ensures that a better discrete minimizer of f can be found by some classical local search methods. Numerical experiments on several test problems with up to 100 integer variables and up to 1.38 × 10104 feasible points have demonstrated the applicability and efficiency of the proposed method.  相似文献   
8.
The purpose of the present study was to describe the effects ofacute laryngitis on some aerodynamic, acoustic, and perceptual measures. Eleven subjects with diagnosed acute laryngitis due to upper respiratory infection were recorded during a laryngitic episode and 1 week to 10 days after amelioration of the laryngitic condition. Fundamental frequency values, collapsed across the five vowels, were significantly reduced in the laryngitic compared with the normal speaking condition. The decrease in fundamental frequency associated with acute laryngitis suggests an increase in the mass of the vocal folds. In addition, aerodynamic values differed significantly for the laryngitic condition compared with the normal speaking condition, suggesting the presence of laryngeal hypofunction. Perceptual data indicated that speakers in the laryngitic condition were judged to have a hoarse voice when compared with the normal speaking condition.  相似文献   
9.
The use of phase-Doppler anemometry (PDA) to characterize the detail in-flight plasma sprayed particle behavior has been demonstrated previously [Ma et al. Plasma Chem Plasma Process 24(1):85; 25(1):56] The present articles shows further that a direct relationship may exist between the PDA measured particle volume flux and the coating microstructure and deposition efficiency (DE). In the situation when the precise particle temperature information is not available, the PDA measured particle volume flux may provide an alternative to predict quantitatively the variation of the coating microstructure and the DE. By monitoring the in-flight particle volume flux variations, instead of the particle velocity, size and temperature individually and simultaneously, the optimal settings of the plasma spraying parameters may also be determined conveniently. However, it is noted that the effective applications of such approach depend largely on the particle surface morphology and the pre-determination of the particle size range.  相似文献   
10.
Bayesian inference is considered for the seemingly unrelated regressions with an elliptically contoured error distribution. We show that the posterior distribution of the regression parameters and the predictive distribution of future observations under elliptical errors assumption are identical to those obtained under independently distributed normal errors when an improper prior is used. This gives inference robustness with respect to departures from the reference case of independent sampling from the normal distribution.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号