Solid-phase parallel synthesis of 1,3,4-oxadiazole based peptidomimetic library as a potential modulator of protein-protein interactions

Design and solid phase synthesis of the 1,3,4-oxadiazole based peptidomimetic library is presented. Library synthesis starts from the coupling of the thiosemicarbazide resin with Fmoc-protected amino acid following desulfurative cyclization to 1,3,4-oxadiazoles. Following substitution of the secondary amine with the 3-nitrobenzoyl functional group and its further reduction were performed. Thus, the functionalization with amino acids could be performed on both sides of the core skeleton. After diversification and cleavage from the resin using TFA: DCM cleavage cocktail, an enantiopure library of compounds was obtained. Further evaluation of physicochemical properties was performed.     

The development of perturbations in the universe described by the nonstationary equation of state

The growth of the perturbation density in a baryon substance due to a nonstationary character of the equation of state of nonbaryon matter in the Universe is studied. It is shown that the perturbations evolve slower than within the Friedmann cosmological model. Translated from Izvestiya Vysshikh Uchebnykh Zavedenii, Fizika, No. 3, pp. 61–67, March, 2009.     

Electrochemical Behavior of Sulfur in Aqueous Alkaline Solutions

Russian Journal of Physical Chemistry A - The kinetics and mechanism of the electrode oxidation-reduction of sulfur on an electrically conductive sulfur–graphite electrode in an alkaline...     

Electrical conductivity of solutions of copper(II) nitrate crystalohydrate in dimethyl sulfoxide

Conductometry is used to investigate the electric conductivity of Cu(NO₃)₂ ? 3Н₂О solutions in dimethyl sulfoxide in the 0.01–2.82 M range of concentrations and at temperatures of 288–318 K. The limiting molar conductivity of the electrolyte and the mobility of Cu²⁺ and NO₃^- ions, the effective coefficients of diffusion of copper(II) ions and nitrate ions, and the degree and constant of electrolytic dissociation are calculated for different temperatures from the experimental results. It is established that solutions containing 0.1–0.6 M copper nitrate trihydrate in DMSO having low viscosity and high electrical conductivity can be used in electrochemical deposition.     

Warm inflation in Horndeski gravity

In this paper, we investigate a class of Horndeski scalar-tensor theory of gravity for warm inflation. We present some models where the early-time acceleration is realized in the weak and in the strong dissipation regime. Cosmological perturbations are analyzed.     

G-essence with Yukawa interactions

We study the g-essence model with Yukawa interactions between a scalar field φ and a Dirac field ψ. For the homogeneous, isotropic and flat Friedmann–Robertson–Walker universe filled with the such g-essence, the exact solution of the model is found. Moreover, we reconstruct the corresponding scalar and fermionic potentials which describe the coupled dynamics of the scalar and fermionic fields. It is shown that some particular g-essence models with Yukawa interactions correspond to the usual and generalized Chaplygin gas unified models of dark energy and dark matter. Also we present some scalar–fermionic Dirac–Born–Infeld models corresponding g-essence models with Yukawa interactions which again describe the unified dark energy–dark matter system.     

CGHS Black Hole Analog Moving Mirror and Its Relativistic Quantum Information as Radiation Reaction

The Callan–Giddings–Harvey–Strominger black hole has a spectrum and temperature that correspond to an accelerated reflecting boundary condition in flat spacetime. The beta coefficients are identical to a moving mirror model, where the acceleration is exponential in laboratory time. The center of the black hole is modeled by the perfectly reflecting regularity condition that red-shifts the field modes, which is the source of the particle creation. In addition to computing the energy flux, we find the corresponding moving mirror parameter associated with the black hole mass and the cosmological constant in the gravitational analog system. Generalized to any mirror trajectory, we derive the self-force (Lorentz–Abraham–Dirac), consistently, expressing it and the Larmor power in connection with entanglement entropy, inviting an interpretation of acceleration radiation in terms of information flow. The mirror self-force and radiative power are applied to the particular CGHS black hole analog moving mirror, which reveals the physics of information at the horizon during asymptotic approach to thermal equilibrium.