Synthesis of β-L-2'''',3''''-Dideoxy-2''''-fluoro-3''''-hydroxy-methylarabinofuranosyl Pyrimidine Nucleosides

L-Nucleosides have attracted considerable attention since many analogs have exhibited a higher antiviral potency and selectivity than their corresponding D-isomers1. In particular, (-)-(2R, 5S)-1-[(2-hydroxymethyl)-oxathiolan-5-yl]cytosine (3TC, Lamivu- dine)2,its 5-fluoro analog [(-)-FTC, Coviracil]3 and (-)--L-2',3'-dideoxy-5-fluorocytidine (L-FddC)4 are in various stages of preclinical or clinical trials as anti-HIV and anti-HBV agents. Furthermore, the introduction of a 2'--fluo…     

High sensitivity and high selectivity terahertz biomedical imaging

We demonstrate two distinct emerging terahertz (THz) biomedical imaging techniques.One is based on the use of a new single frequency THz quantum cascade laser and the other is based on broadband THz time domain spectrocopy.The first method is employed to derive a metastasis lung tissue imaging at 3.7 THz with clear contrast between cancerous and healthy areas.The second approach is used to study an osseous tissue under several imaging modalities and achieve full THz spectroscopic imaging based on the freque...     

Detection of meso-micro scale surface features based on microcanonical multifractal formalism

Synthetic aperture radar(SAR) is an effective tool to analyze the features of the ocean. In this paper, the microcanonical multifractal formalism is used to analyze SAR images to obtain meso-micro scale surface features. We use the Sobel operator to calculate the gradient of each point in the image, then operate continuous variable scale wavelet transform on this gradient matrix. The relationship between the wavelet coefficient and scale is built by linear regression. This relationship decides the singular exponents of every point in the image which contain local and global features. The manifolds in the ocean can be revealed by analyzing these exponents. The most singular manifold, which is related to the streamlines in the SAR images, can be obtained with a suitable threshold of the singular exponents. Experiments verify that application of the microcanonical multifractal formalism to SAR image analysis is effective for detecting the meso-micro scale surface information.     

ANALYSIS OF THE X-RAY PHOTOELECTRON SPECTRA OF a-SiOCF FILMS PREPARED BY PLASMA-ENHANCED CHEMICAL VAPOUR DEPOSITION

The preparation of a-SiOCF films from Si(OC₂H₅)₄, C₄F₈ and/or Ar using the plasma-enhanced chemical vapour deposition method is reported. The chemical bonding structures of the films are analysed by x-ray photoelectron spectroscopy (XPS). In the case of the films deposited from the mixture with and without Ar, the configurations of F-Si-O-Si, Si-OH, Si-O-Si, C-CF and C-F are contained. However, there is also the C-C configuration in the film prepared from the mixture with Ar. Moreover, it is found that the photoelectron peaks of Si 2p, O 1s and F 1s for the film deposited from the feeding gas with Ar show the same shift of about 1eV toward high binding energy in comparison with those for the film prepared from the feeding gas without Ar. No evidence reveals the presence of an Si-C bond in the films.     

Complete noncompact manifolds with harmonic curvature

Let (M ⁿ , g) be an n-dimensional complete noncompact Riemannian manifold with harmonic curvature and positive Sobolev constant. In this paper, by employing an elliptic estimation method, we show that (M ⁿ , g) is a space form if it has sufficiently small L ^n/2-norms of trace-free curvature tensor and nonnegative scalar curvature. Moreover, we get a gap theorem for (M ⁿ , g) with positive scalar curvature.     

Synthesis, Characterization, Spectroscopic Properties of 2-（4-Dimethylaminophenyl）-5-fluoro-6-（morpholin-4-yl）-1H-benzimidazole and its Interaction with Calf Thymus DNA

Benzimidazole compounds have attracted a renewed interest recently owing to theirpotential applications in high-performance composite materials, electronic chemicals,photosensitive materials, and their special potentials in biological and/or medicinalapplication1,2. Typically, aromatic compounds with near planar structures and contain-ing hydrogen-donor groups or groups, which are capable of being protonated, havespecial interactions with DNA via intercalation, hydrogen-bonding, and so on3.Me…     

Liquid Chromatography-Electrospray Quadrupole Linear Ion Trap Mass Spectrometric Method for Quantitation of Domperidone in Chinese Healthy Volunteers

A rapid,sensitive,and accurate method based on LC/MS/MS was developed and validated for the determination of domperidone in human plasma.Domperidone and internal standard,tramadol,were extracted from plasma with diethyl ether-dichloromethane(60∶40,volume ratio)and separated by reversed-phase HPLC with methanol-water-ammonia solution(80∶20∶0.2,volume ratio)as the mobile phase.Detection was carried out via multiple-reaction monitoring(MRM)on a Q-trapTM LC/MS/MS system(Q-trapTM).The assay result was linear over a concentration range of 0.1-30 ng/mL with a limit of quantitation(LOQ)of 0.1 ng/mL.The inter-and intra-day precision levels were within 7.52% and 12.9%,respectively,whereas the accuracy was within a range of 87.3%-114%.This method has been successfully applied to evaluate the pharmacokinetics of domperidone in Chinese healthy volunteers given an oral dose of 10 mg.     

Sharp power mean bounds for Sei?ert mean简

In this paper,we find the greatest value p = log2/(log π. log 2) = 1.53 ··· and the least value q = 5/3 = 1.66 ··· such that the double inequality Mp(a,b) T(a,b) Mq(a,b) holds for all a,b 0 with a = b. Here,Mp(a,b) and T(a,b) are the p-th power and Seiffert means of two positive numbers a and b,respectively.     

盐湖卤水中微量钒的浓度测定

为了测定盐湖卤水中微量钒的浓度,开发了一个钒的分离纯化流程来降低大量的共存离子的基质效应。该分离纯化流程包括萃取和反萃两个步骤。详细地研究了影响钒纯化效率的各种因素,得到钒的最佳分离纯化条件为:以正己烷为稀释剂,有机相中D2EHPA和TBP的体积百分比分别为30%及20%,在pH为3.0时萃取30 min;然后用3 mol/L H₂SO₄反萃 10 min。基于此分离纯化流程,将两个实际盐湖卤水样品中的微量钒纯化后,再用电感耦合等离子体质谱仪(ICP-MS)测定其浓度,该ICP-MS对51V 的检测灵敏度和检测限别为53 171 cps/(μg/L) 和1.88 ng/L。所得实际盐湖卤水钒测定结果的加标回收率接近100%而相对标准偏差低于0.6%,表明该方法可用于实际复杂体系中微量钒的浓度测定,例如海水和盐湖卤水。     

A text-to-speech system with high intelligibility and naturalness for Chinese

I.IntroductionResearchesonChinesesynthesisdisclosethatonlywhenboththesegmentalandsupraseg-melltalfeaturesofthesyntheticspeecharesimilartothoseofthellaturalone,thesyntheticspeechwillsoundintelligibleandnatural[1].Amongekistingsynthetictechniques,theapproachbasedonacousticparametersca-nadustboththesegmentalandsuprasegmentalfeaturesofsyntheticunitsfiekiblyandcanbeconsideredasthemostreasonablesynthetictechniqueintheory.However,theparameterbasedsynthesizerisoverAfependentonthedevelopmentsofparamet…