Detecting the vector of nanoscale light field with atomic defect

Modulation of a vector light field has played an important role in the research of nanophotonics. However, it is still a great challenge to accurately measure the three-dimensional vector distribution at nanoscale. Here, based on the interaction between the light field and atomic-sized nitrogen-vacancy(NV) color center in diamonds, we demonstrate an efficient method for vectorial mapping of the light-field distribution at nanoscale. Single NV centers with different but well-defined symmetry axes...     

基于代谢组学和特征分子网络技术分析小鼠体内氧氟沙星的代谢产物

借助超高效液相色谱-四极杆串联飞行时间质谱（UHPLC-Q-TOF MS），结合代谢组学及特征分子网络（FBMN）技术，分析氧氟沙星在小鼠肌肉、结肠、肝脏、肾脏、回肠及内容物中的代谢产物。依据人类代谢组数据库（HMDB），利用代谢组学软件Progenesis QI鉴定出小鼠体内氧氟沙星的2种代谢产物，分别为N-氧化产物和培氟沙星；在FBMN技术下，依据可视化结果鉴定出5种代谢产物，其中两种与QI鉴定结果相同，另外3种分别为脱羧产物、脱羧后N-脱烷基化产物、脱氨后开环脱羧产物。采用所建立的方法快速分析了小鼠体内氧氟沙星的代谢产物。该方法具有快速、准确、无需标准品等特点，在其他代谢产物的分析方面具有广泛的应用前景。