单粒子束精确定位照射装置在CR-39膜上刻蚀中国地图边界研究

采用自编写的图像处理程序把中国地图处理成为边界点阵图，并根据点阵图每点的坐标位置，利用中国第1台单粒子束精确定位照射装置提供的单质子束在CR-39膜上几百μm×几百μm的范围内辐照并刻蚀出中国地图边界. 研究表明，该单粒子束精确定位照射装置计数准确(98%)，定位精确(平均误差小于3 μm)，辐照路径算法选择合理(近邻法)，预测值和实测值吻合程度高，可以满足刻蚀CR-39膜微图像和生物细胞辐照实验的要求.     

纤维素纤维接枝β-环糊精的合成及其富集金属离子研究

以环氧氯丙烷作为化学修饰剂 ,在碱性介质中将 β 环糊精接枝到粘胶纤维上 ,合成了接枝 β 环糊精的功能性纤维素纤维 ,接枝 β 环糊精纤维素纤维上 β 环糊精的含量为 7 8%。研究了接枝 β 环糊精的纤维素纤维对模拟水样中无机重金属离子的富集性能 ,考察了温度、浓度、pH值对富集性能的影响 .实验结果表明 ,接枝 β 环糊精的纤维素纤维对无机重金属离子 (Cu2 + 、Pb2 + + 、Cd2 + )富集效果良好 ,其富集容量分别达到 0 2 5mmol g、0 30mmol g、0 34mmol g ,Cu2 + 、Pb2 + 、Cd2 + 与 β 环糊精富集摩尔比分别为 2 9∶1、3 9∶1、4 3∶1。     

新型水溶性钴酞菁的制备及其催化氧化硫醇的性能

采用丁二酸酐、顺丁烯二酸酐对四氨基钴酞菁进行改性后制得两种新型水溶性钴酞菁衍生物, 测试了这两种改性钴酞菁对巯基乙醇的催化氧化性能, 并考察了溶液pH值、温度和时间对催化氧化活性的影响, 结果表明, 在pH＝11时, 两种改性钴酞菁对巯基乙醇的催化氧化性能最好;随着温度的升高, 催化氧化性能提高.     

In Vivo Magnetic Particle Targeting by Local Gradient Field of Interstitial Seeds Magnetized in an Ex Vivo Uniform Field

The possibility of in vivo magnetic particle targeting by the locally induced gradient field of interstitial ferro- magnetic implants, magnetized in an ex vivo uniform field, is evaluated by a modelling analysis. A simplified 3D model analogous to a torso size, with a continuous laminar flow through the volume with the typical velocity and viscosity values of in vivo blood flow and a ferromagnetic seed inserted in the volume center vertical to the flow, is used to evaluate the magnetic particle capturing efficiency by the seed, which is magnetized in a uniform field. The initial modelling results indicate that for 1-10μm iron oxide particles transporting with a blood flow of 0.5-5 mm/s, the seeds of tungsten steel, magnet steel and cast cobalt all present an effective particle capturing efficiency, which shows a fast initial increase and a slow saturation with the increasing magnetic field, a quasilinear increase with the increasing particle size, and a nonlinear decrease with the increasing blood velocity.     

CAS-LIBB单粒子微束装置的微束入射点位置确定和系统定位精度研究

中国科学院离子束生物工程学重点实验室建成了一台单离子微束装置(CAS-LIBB)。CAS-LIBB装置由一台van de Graaff 静电加速器产生能量在2.0-3.0 MeV 的离子。该微束系统主要用于实施对生长在一种薄塑料膜上的细胞核的指定位置投射预定个数离子的技术。系统采用安装在束流末端的石英毛细玻璃管作为瞄准器来实现束流的微化并截取微束。细胞辐射实验中对细胞的识别和定位由一套计算机集成控制程序来完成。本文将从对微束的捕捉和定位（确定离子出口的准确位置），以及该微束系统的定位精度测量方面进行研究和讨论。当采用内径为5 μm,长度为980 μm的毛细管作瞄准器时，系统的定位精度为：91％的实验对象定位在距离预定位置2.4μm的范围内，98％的实验对象定位在距离预定位置3.6μm的范围内。     

Elaborate calibration procedure for cell irradiation at the CAS-LIBB single-particle microbeam

Single-particle microbeam is uniquely capable of precisely delivering a preset number of charged particles to individual cells or sub-cellular targets to be determined in vitro. It is crucial to find a reference point that relates the microbeam's location to the microscope's plane, and align individual targets at this reference point for cell irradiation. To choose an appropriate reference point, an approach based on analysing the intensity distribution of fluorescence in a thin scintillator excited by traversing particles is newly developed using the CAS-LIBB single-particle microbeam,which features decisive physical signification and sufficient resolution. As its bonus, this on-line analysis provides precise and fast response to the determination of beam profile and potentially optimizes the microbeam quality by further adjusting hardware setup.     

Quantitative Single-Ion Irradiation by ASIPP Microbeam

A single-ion microbeam facility has been constructed by the microbeam research group in ASIPP (Institute of Plasma Physics, Chinese Academy of Science). The system was designed to deliver defined numbers of hydrogen ions produced by a van de Graaff accelerator, covering an energy range from 200 keV to 3 MeV, into living cells (5μm-20μm diameter) growing in culture on thin plastic films. The beam is collimated by a 1-μm inner diameter HPLC (high performance liquid chromatograph) capillary, which forms the micron-dimensional beam-line exit. A microbeam collimator, a scintillation ion counting system and a fast beam shutter, which constitute a precise dosage measuring and controlling system, jointly perform quantitative single-ion irradiation. With this facility, we can presently acquire ion-hitting efficiency close to 95%.     

单粒子束装置中束线开关的研究

介绍了国内第一台单粒子束装置中束线开关的控制原理，通过实验验证了束线开关的反应时间在5μs以内，满足实际工作需要。     

Microdosimetric Evaluation on the Metallic Nanoparticle-Mediated Dose Enhancement in Radiotherapeutic Proton Irradiation

Monte Carlo simulations are performed on the dosimetric effect of metallic nanoparticles in a clinical proton irradiation.With an in-water hitting model of a single nanoparticle,the secondar.y electrons dose,deposited around the particle surface,is calculated for the proton irradiations in a typical spread-out Bragg peak.The dose enhancement,as the ratio of electron doses from the target particle and background water,is evaluated for the dependence on the depth of hitting,particle size,elements,coating material and thickness.The results indicate a significant dose enhancement on the particle surface within-200 nm,but a fast decay in further distance.The dose enhancement presents a consistency along the spread-out Bragg peak,a positive dependence on both the particle size and electron density,but a strong attenuation by surface coating.Particle cluster may increase the incdividual dose enhajncement by electron crossfire,but is only noticeable in a compact case.The dose enhancement potentiates a radiosensitization use of metallic nanoparticles in clinical proton therapy,but challenqging meanwhile with the narrow ranqge of enhancement effect.     

毛细管准直微束过程模拟与微束品质分析

利用GEANT4程序对复旦大学单粒子微束的毛细管准直过程进行了蒙特卡罗模拟。计算结果表明:当前采用的1 m孔径、1 mm长度的毛细玻璃管准直器能够引出峰值能量2.2 MeV、能量分辨130 keV、束径2.4 m的质子微束,可达到装置对微束能量与束径分辨的设计指标,从理论上明确了毛细管准直微束引出的可行性。针对影响入射目标细胞微束品质的主要因素,分析了微束品质与准直系统和入射束流各状态参数的依赖关系,为毛细管准直微束的引出与优化提供了必要的理论依据。