利用轨迹自动识别方法研究单细胞内表皮生长因子受体的运输

利用基于方向持续度及均方位移的轨迹自动识别方法,研究了单细胞内表皮生长因子受体(EGFR)运输轨迹的模式特征,将EGFR运动逐段划分为定向运动、超扩散运动、布朗运动和次扩散运动四种模式,计算了不同运动模式的动力学参数并讨论了其所揭示的受体运动的生物信息.     

Brownian dynamics simulation of the cross-talking effect among modified histones on conformations of nucleosomes

Using Brownian dynamics simulation,we studied the effect of histone modifications on conformations of an array of nucleosomes in a segment of chromatin.The simulation demonstrated that the segment of chromatin shows the dynamic behaviour that its conformation can switch between a state with nearly all of the histones being wrapped by DNA and a state with nearly all of the histones being unwrapped by DNA,thus involving the "cross-talking" interactions among the histones.Each state can stay for a sufficiently long time.These conformational states are essential for gene expression or gene silence.The simulation also shows that these conformational states can be inherited by the daughter DNAs during DNA replication,giving a theoretical explanation of the epigenetic phenomenon.