Here, a series of shape‐controllable and fluorescent supramolecular organic frameworks (SOFs) exhibiting aggregation‐induced emission (AIE) are reported as a new kind of tunable luminescent material, constructed hierarchically from fluorescent guests (1–5) and cucurbit[8]uril (CB[8]) through homo/hetero host–guest complexation in water. These SOFs can further form regular supramolecular cuboids via a hierarchical assembly process in the solid state. Interestingly, the emission of hetero‐SOFs systems exhibiting AIE, which are a combination of two or three SOFs with two complementary colors (i.e., yellow and blue) or three primary RGB colors (red, green, and blue) through the hetero host–guest complexation between CB[8] and two pyridinium rings of different guests, can be easily tuned by adjusting the excitation wavelength and guests ratios, thereby achieving a wide‐color tunability (≈64% sRGB area) and white‐light emission (0.31, 0.34) in the solution state. This study therefore provides insight into the fabrication of tunable luminescent materials based on SOFs with controllable shapes and AIE properties as fluorescent platforms, and may facilitate the further design and synthesis of tunable luminescent materials and other fluorescent supramolecular systems based on host–guest complexation both in the solution and solid states. 相似文献
CDDP is loaded into methoxypoly(ethylene glycol)‐block‐poly(L ‐glutamic acid) (mPEG‐b‐PLG), and a combination with iRGD is applied for NSCLC chemotherapy. The CDDP‐loaded micelles show sustained cisplatin release in PBS, dose‐ and time‐dependent inhibition to HeLa and A549 cell proliferation, and no apparent hemolysis activities. In in vivo studies using subcutaneous NSCLC xenograft models (A549), both free CDDP and CDDP‐loaded micelles show an evident anti‐tumor effect. However, the toxicity of CDDP is significantly reduced in the cases of CDDP‐loaded micelles and co‐administration with iRGD, and the survival time is prolonged by over 30%. Therefore, mPEG‐b‐PLG‐loaded cisplatin and the combination with iRGD provides a promising new therapy for NSCLC.
Rapid and efficient side‐chain functionalization of polypeptide with neighboring carboxylgroups is achieved via the combination of ring‐opening polymerization and subsequent thiol‐yne click chemistry. The spontaneous formation of polymersomes with uniform size is found to occur in aqueous medium via electrostatic interaction between the anionic polypeptide and cationic doxorubicin hydrochloride (DOX·HCl). The polymersomes are taken up by A549 cells via endocytosis, with a slightly lower cytotoxicity compared with free DOX ·HCl. Moreover, the drug‐loaded polymersomes exhibit the enhanced therapeutic efficacy, increase apoptosis in tumor tissues, and reduce systemic toxicity in nude mice bearing A549 lung cancer xenograft, in comparison with free DOX ·HCl. 相似文献
This paper is concerned with the traveling waves of a reaction-diffusion SIRQ epidemic model with relapse. We find that the existence and nonexistence of traveling waves are determined by the basic reproduction number of the system and the minimal wave speed. This threshold dynamics is proved by Schauder''s fixed-point theorem combining Lyapunov functional with the theory of asymptotic spreading. Moreover, the numerical simulations are provided to illustrate our analytical results and the effect of the relapse is also discussed. 相似文献
