Biosensor for dopamine based on stabilized lipid films with incorporated resorcin[4]arene receptor

This work reports a technique for the stabilization after storage in air of a lipid film with incorporated resorcin[4]arene receptor based biosensor for dopamine. Microporous filters composed of glass fibers (nominal pore sizes, 0.7 and 1.0 microm) were used as supports for the formation and stabilization of these devices and the lipid film is formed on the filter by polymerization prior its use. Methacrylic acid was the functional monomer, ethylene glycol dimethacrylate was the crosslinker and 2,2'-azobis-(2-methylpropionitrile) was the initiator. The stability of the lipid films by incorporation of a receptor for the preparation of stabilized lipid film biosensor is studied throughout this work. The response towards dopamine of the present stabilized for repetitive uses lipid membrane biosensor composed of dipalmitoyl phosphatidylcholine and dipalmitoyl phosphatidic acid was compared with planar freely suspended bilayer lipid membranes (BLMs). The stabilized lipid membranes provided similar artificial ion gating events as BLMs in the form of transient signals and can function for repetitive uses after storage in air. However, the response of the stabilized lipid films was slower than that of the freely suspended BLMs. This will allow the practical use of the techniques for chemical sensing based on lipid films and commercialization of these devices, because it is now possible to prepare stabilized lipid film based biosensors and store them in the air.     

Synthesis of ertugliflozin from d-glucose

A new synthesis of ertugliflozin from d-glucose in 7% overall yield is reported. The reaction sequence involves conversion of d-glucose to a fully protected open chain d-glucose aldehyde in 4 steps, further installation of the aglycon group by a Grignard reaction, introduction of the hydroxymethyl group by a sequential oxidation/aldol reaction/Canizzarro reduction, and finally benzylic oxidation and global deprotection.     

Non-Existence of Real Hypersurfaces Equipped with Recurrent Structure Jacobi Operator in Nonflat Complex Space Forms

The aim of the present paper is to prove the non-existence of real hypersurfaces equipped with recurrent structure Jacobi operator in a non-flat complex space form.     

Parameter identification of 1D fractal interpolation functions using bounding volumes

Fractal interpolation functions are very useful in capturing data that exhibit an irregular (non-smooth) structure. Two new methods to identify the vertical scaling factors of such functions are presented. In particular, they minimize the area of the symmetric difference between the bounding volumes of the data points and their transformed images. Comparative results with existing methods are given that establish the proposed ones as attractive alternatives. In general, they outperform existing methods for both low and high compression ratios. Moreover, lower and upper bounds for the vertical scaling factors that are computed by the first method are presented.