Spectroscopic diagnosis of colonic dysplasia.

We have developed a method for defining diagnostic algorithms for pathologic conditions based on fluorescence spectroscopy. We apply this method to human colon tissue and show that fluorescence can be used to diagnose the presence or absence of colonic adenoma. This method uses fluorescence excitation-emission matrices (EEM) to identify optimal excitation regions for obtaining fluorescence emission spectra which can be used to differentiate normal and pathologic tissues. In the case of normal and adenomatous colon tissue, these were found to be: 330, 370, and 430 nm +/- 10 nm. At these excitation wavelengths, emission wavelengths for use in diagnostic algorithms are identified from average difference and ratio of the spectra from normal and pathologic tissues. In colon tissue, at 370 nm excitation, 404, 480, and 680 nm were found to be useful emission wavelengths for diagnosing the presence of adenoma in vitro. The basis of colon tissue autofluorescence was investigated using EEM of pure molecules and relevant excitation-emission maxima in the literature.     

3-Cyanoazolo[5,1-c][1,2,4]triazines: synthesis and antiviral activity

Chemistry of Heterocyclic Compounds - A series of azolo[5,1-c][1,2,4]triazines containing a cyano group were prepared as analogs of the drug Triazavirin (riamilovir). Sodium...     

Experimental study of the behavior of a cylindrical shell under impulsive loading with ambient humidity taken into account

A procedure and results of experimental determination of the vibroacceleration of a cylindrical shell that is in contact with an ambient medium are presented. It is revealed that the vibroacceleration of the shell is maximum at resonance. Its dependence on the height from which a weight is dropped on the shell to generate a shock load is established     

Vibrations of a system of fluid-filled cylindrical shells on an elastic base

The resonance synchronization of the vibrations of a system of shells is studied. It is established that the vibrations of isolated components excite the vibrations of the whole system, consisting of three cylindrical shells on a common elastic base.__________Translated from Prikladnaya Mekhanika, Vol. 40, No. 12, pp. 134–137, December 2004.     

Some luminescent properties of additively colored KBr · Ag crystals

The luminescent characteristics of additively colored KBr · Ag crystals are investigated. In particular, the decay of the phosphorescence, the flash of emission due to IR light in relation to the silver concentration, and the temperature quenching of the steady luminescence are discussed. It is shown that the investigated crystals have a complex system of shallow and deep traps. The thermal activation energy for nonradiative transitions in the B centers is found. It is concluded that the luminescence is produced by an electron-recombination mechanism.Translated from Izvestiya Vysshikh Uchebnykh Zavedenii, Fizika, No. 11, pp. 81–85, November, 1973.     

Friedel oscillations in a relativistic quantum plasma

The linear responce of a two-component plasma to a static test charge is analyzed at large distances from the impurity. The electrons are considered relativistic and degenerate and the ions classical and non-relativistic. The results show that the electrons give the principal contribution to the response, which is long ranged and characterized by the Friedel oscillatory behavior.     

Fabrication of Aquivion-type membranes and optimization of their elastic and transport characteristics

The solution casting technology was applied to manufacture thin polymer films (~?20–30 μm) from the ionomer solution of perfluorinated polymer with short side chains (an analogue of the commercial polymer Aquivion®). The influence of annealing temperature on the mechanical properties (elastic limit), proton conductivity, and heat capacity was investigated. The elastic limit, glass transition temperature, and proton conductivity of the samples were found to reach their maximum values at the annealing temperature 170?±?5 °C. Comparative studies of membrane-electrode assemblies (MEA) using the commercial (Nafion NR212) and solution-casted membranes were carried out. MEA with optimized Aquivion-type membranes showed satisfactory values of fuel crossover and maximum output power. The results of the conducted studies show that the prepared Aquivion-type membranes are very promising for practical application in MEA.     

Thermal relaxation of defects in nanosized mechanically activated МоО<Subscript>3</Subscript>

The regularities of the thermal relaxation of structural defects (paramagnetic centers and microdistortions), as well as the sizes of coherent-scattering regions and the external surface, of mechanically activated МоО₃ have been studied with the use of X-ray diffraction, electron paramagnetic resonance, and adsorption/desorption methods. It has been revealed that heating of activated samples at temperatures below 450°C is accompanied by the death of paramagnetic centers, annealing of microdistortions, and liberation of molecular oxygen. It has been assumed that oxygen results from the rupture of deformed Mo–O–Mo bridge bonds formed by its atoms. Above 450°C, recrystallization processes occur, which are accompanied by an increase in the sizes of the coherent-scattering regions and the MoO₃ (monoclinic) → MoO₃ (orthorhombic) phase transition. The thermal stability of the external particle surface depends on mechanical activation conditions. For samples activated at early stages of activation (fracture regime), the specific surface area decreases by more than an order of magnitude, when a temperature of 450°C is reached. At higher activation doses (friction regime), the sample is not sintered in the same temperature range.     

Near-equilibrium measurements of nonequilibrium free energy

A central endeavor of thermodynamics is the measurement of free energy changes. Regrettably, although we can measure the free energy of a system in thermodynamic equilibrium, typically all we can say about the free energy of a nonequilibrium ensemble is that it is larger than that of the same system at equilibrium. Herein, we derive a formally exact expression for the probability distribution of a driven system, which involves path ensemble averages of the work over trajectories of the time-reversed system. From this we find a simple near-equilibrium approximation for the free energy in terms of an excess mean time-reversed work, which can be experimentally measured on real systems. With analysis and computer simulation, we demonstrate the accuracy of our approximations for several simple models.