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Sidney C. Scull 《Reports on Mathematical Physics》1976,10(1):1-7
The spectrum of self-adjoint operators arising from unitary representations of semi-simple Lie groups is investigated. A series of irreducible unitary representations in which certain generators of non-compact one-parameter subgroups are realized by positive operators is described. These representations occur only for groups of automorphisms of bounded symmetric domains. 相似文献
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Laura Scull 《Transactions of the American Mathematical Society》2008,360(5):2505-2525
In the equivariant category of spaces with an action of a finite group, algebraic `minimal models' exist which describe the rational homotopy for -spaces which are 1-connected and of finite type. These models are diagrams of commutative differential graded algebras. In this paper we prove that a model category structure exists on this diagram category in such a way that the equivariant minimal models are cofibrant objects. We show that with this model structure, there is a Quillen equivalence between the equivariant category of rational -spaces satisfying the above conditions and the algebraic category of the models.
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Kyung Ho Cho Dr. Yang Du Nicola J. Scull Dr. Parameswaran Hariharan Prof. Kamil Gotfryd Prof. Claus J. Loland Prof. Lan Guan Dr. Bernadette Byrne Prof. Brian K. Kobilka Prof. Pil Seok Chae 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(28):10008-10013
Membrane proteins are key functional players in biological systems. These biomacromolecules contain both hydrophilic and hydrophobic regions and thus amphipathic molecules are necessary to extract membrane proteins from their native lipid environments and stabilise them in aqueous solutions. Conventional detergents are commonly used for membrane protein manipulation, but membrane proteins surrounded by these agents often undergo denaturation and aggregation. In this study, a novel class of maltoside‐bearing amphiphiles, with a xylene linker in the central region, designated xylene‐linked maltoside amphiphiles (XMAs) was developed. When these novel agents were evaluated with a number of membrane proteins, it was found that XMA‐4 and XMA‐5 have particularly favourable efficacy with respect to membrane protein stabilisation, indicating that these agents hold significant potential for membrane protein structural study. 相似文献
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Accessible Mannitol‐Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and Stabilisation
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Hazrat Hussain Dr. Yang Du Nicola J. Scull Jonas S. Mortensen Jeffrey Tarrasch Hyoung Eun Bae Prof. Claus J. Loland Dr. Bernadette Byrne Prof. Brian K. Kobilka Prof. Pil Seok Chae 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(21):7068-7073
Integral membrane proteins are amphipathic molecules crucial for all cellular life. The structural study of these macromolecules starts with protein extraction from the native membranes, followed by purification and crystallisation. Detergents are essential tools for these processes, but detergent‐solubilised membrane proteins often denature and aggregate, resulting in loss of both structure and function. In this study, a novel class of agents, designated mannitol‐based amphiphiles (MNAs), were prepared and characterised for their ability to solubilise and stabilise membrane proteins. Some of MNAs conferred enhanced stability to four membrane proteins including a G protein‐coupled receptor (GPCR), the β2 adrenergic receptor (β2AR), compared to both n‐dodecyl‐d ‐maltoside (DDM) and the other MNAs. These agents were also better than DDM for electron microscopy analysis of the β2AR. The ease of preparation together with the enhanced membrane protein stabilisation efficacy demonstrates the value of these agents for future membrane protein research. 相似文献
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Lianet Monzote Alexander M. Scherbakov Ramn Scull Prabodh Satyal Paul Cos Andrey E. Shchekotikhin Lars Gille William N. Setzer 《Molecules (Basel, Switzerland)》2020,25(23)
Essential oils (EOs) are known for their use in cosmetics, food industries, and traditional medicine. This study presents the chemical composition and therapeutic properties against kinetoplastid and eukaryotic cells of the EO from Melaleuca leucadendra (L.) L. (Myrtaceae). Forty-five compounds were identified in the oil by GC-MS, containing a major component the 1,8-cineole (61%). The EO inhibits the growth of Leishmania amazonensis and Trypanosoma brucei at IC50 values <10 μg/mL. However, 1,8 cineole was not the main compound responsible for the activity. Against malignant (22Rv1, MCF-7, EFO-21, including resistant sublines MCF-7/Rap and MCF-7/4OHTAMO) and non-malignant (MCF-10A, J774A.1 and peritoneal macrophage) cells, IC50 values from 55 to 98 μg/mL and from 94 to 144 μg/mL were obtained, respectively. However, no activity was observed on Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger, Candida parapsilosis, Microsporum canis, or Trypanosoma cruzi. The EO was able to control the lesion size and parasite burden in the model of cutaneous leishmaniasis in BALB/c mice caused by L. amazonensis compared to untreated animals (p < 0.05) and similar with those treated with Glucantime® (p > 0.05). This work constitutes the first evidence of antiproliferative potentialities of EO from M. leucadendra growing in Cuba and could promote further preclinical investigations to confirm the medical value of this plant, in particular for leishmaniasis treatment. 相似文献
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Laura Scull 《Transactions of the American Mathematical Society》2002,354(1):1-45
We give an algebraicization of rational -equivariant homotopy theory. There is an algebraic category of `` -systems' which is equivalent to the homotopy category of rational -simply connected -spaces. There is also a theory of ``minimal models' for -systems, analogous to Sullivan's minimal algebras. Each -space has an associated minimal -system which encodes all of its rational homotopy information, including its rational equivariant cohomology and Postnikov decomposition.
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We describe some algebraic models for equivariant rational and p-adic homotopy theory over Abelian compact Lie groups.
Received: 12 February 2001; in final form: 15 August 2001 / Published online: 28 February 2002 相似文献
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Laura Scull 《Mathematische Zeitschrift》2007,257(3):547-562
We consider simply connected compact Kähler manifolds which have a holomorphic action of a torus group. We use the existing equivariant models for rational homotopy to show that these spaces satisfy an equivariant formality condition over the complex numbers. 相似文献
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In countries where leishmaniasis is endemic, there are not very many treatment alternatives and most options have problems associated with their use. Plants and their natural products constitute good sources of interesting lead compounds that could be potentially active against Leishmania. Chenopodium ambrosioides is a plant that is widely used in popular medicine and its antiparasitic effects have been documented, including the antileishmanial potentialities of Chenopodium oil. The objective of this study was to determine the chemical composition, in-vitro cytotoxicity and antileishmanial activity of essential oils extracted from C. ambrosioides, which received different treatments prior to extraction. The chemical characterization by GC-MS of the three essential oil samples showed similar composition and the major components were alpha-terpinene (17.0-20.7%), p-cymene (20.2-21.1%) and ascaridole (30.5-47.1%). The essential oils exhibited similar antileishmanial activities against intracellular amastigote form, with IC50 values between 4.7 and 12.4 microg/mL. However, a lower cytotoxicity was displayed by the essential oil extracted from fresh green vegetable material, which was statistically different (P < 0.05) from the other samples. This study demonstrated that the prior treatment of plant material did not interfere with the antiparasitic activity of essential oils from C. ambrosioides but did change their cytotoxicity, which should be taken into account in further studies. 相似文献
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