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Neshev N. I. Sokolova E. M. Psikha B. L. Rudneva T. N. Sanina N. A. 《Russian Chemical Bulletin》2016,65(3):779-783
Russian Chemical Bulletin - The kinetic regularities of nitric oxide donation in the presence of erythrocytes by representatives of a new class of synthetic nitric oxide donors, binuclear... 相似文献
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Kovalchuk M. V. Borisov M. M. Garmatina A. A. Gordienko V. M. Zheltikov A. M. Kvardakov V. V. Korchuganov V. N. Likhachev I. A. Mareev E. I. Mitrofanov A. V. Nazarov M. M. Pashaev E. M. Potemkin F. V. Romanovskii Ya. O. Rudneva E. B. Sidorov-Biryukov D. A. Subbotin I. A. Chashchin M. V. Shcheglov P. A. Panchenko V. Ya. 《Crystallography Reports》2022,67(5):717-728
Crystallography Reports - The laser-synchrotron facility (LSF) of the National Research Centre “Kurchatov Institute” (NRC KI) is a unique research complex that combines unprecedented... 相似文献
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Kaminskii A. A. Manomenova V. L. Rudneva E. B. Sorokina N. I. Grebenev V. V. Kozlova N. N. Angeluts A. A. Ozheredov I. A. Solyankin P. M. Denisyuk I. Yu. Fokina M. I. Zulina N. A. Shkurinov A. P. Voloshin A. E. 《Crystallography Reports》2019,64(4):669-677
Crystallography Reports - Aqueous solutions of guanylurea hydrogen phosphite (GUHP) have been synthesized. The temperature dependence of equilibrium GUHP concentration in water was obtained. The... 相似文献
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N. I. Neshev B. L. Psikha E. M. Sokolova N. A. Sanina T. N. Rudneva S. V. Blokhina 《Russian Chemical Bulletin》2010,59(12):2215-2218
The kinetics of erythrocyte hemolysis and intra-erythrocyte hemoglobin oxidation under the action of synthetic sulfur-nitrosyl
iron complexes was studied. The complexes capable of releasing nitric oxide due to spontaneous hydrolytic decomposition was
studied. The addition of these complexes to a 0.2% suspension of mouse erythrocytes results in hemolysis. The kinetic curves
of hemolysis exhibit an induction period, whose duration is different for each complex. The hemolysis is preceded by hemoglobin
oxidation with nitric oxide penetrating into the cell. The oxidation of hemoglobin follows the first-order rate equation.
The apparent first-order rate constants characterizing the NO-donating ability of each complex were determined. The hemolytic
effect of the studied complexes is suggested to be related to the formation of peroxynitrite inside erythrocytes. Peroxynitrite
is the cytotoxic product of interaction of nitric oxide and the superoxide radical anion. 相似文献
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N. A. Sanina L. A. Syrtsova N. I. Shkondina T. N. Rudneva A. I. Kotel’nikov S. M. Aldoshin 《Russian Chemical Bulletin》2010,59(8):1565-1571
By an example of cysteamine iron nitrosyl complex {Fe2[S(CH2)2NH3]2(NO)4}SO4 ? 2.5H2O (CAC) it was shown for the first time that the NO donor hydrolysis in the presence of ferricytochrome c (cyt c3+) affords the iron nitrosyl complex NO—cyt c3+. It was found that cyt c3+ can serve as a depot for NO evolved during the hydrolysis of CAC. In the presence of CAC, the rate of NO—cyt c3+ complex decomposition to NO and cyt c3+ depends on the molar ratio [cyt c3+]: [CAC] and at [cyt c3+]: [CAC] = 0.3 it was found to be lower than that in decomposition of CAC in the absence of cyt c3+. As a result, the total NO evolving process becomes 5.6 times more prolonged. The number of NO groups evolved from CAC can be determined by the reaction of CAC with cyt c3+ in the presence of ferricyanide: at most one NO group is evolved to a solution in the spontaneous hydrolysis of CAC (pH 7.0), and no less than three of them are evolved from oxidized CAC. 相似文献
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L. A. Syrtsova N. A. Sanina A. F. Shestakov N. I. Shkondina T. N. Rudneva N. S. Emel’yanova A. I. Kotel’nikov S. M. Aldoshin 《Russian Chemical Bulletin》2010,59(12):2203-2214
The hydrolysis of the iron nitrosyl complex [Fe2(μ2-SC4H3N2)2(NO)4](C4H3N2S? is pyrimidine-2-thiolate) in the presence of hemoglobin (Hb) is accompanied by the NO release into a solution. In the absence of Hb, the starting complex is oxidized by nitric oxide that is released into a solution, which leads to further transformations of NO, nitric oxide being present in the solution only partially. The effective rate constant for the decomposition of the complex is high and depends on its concentration. On the one hand, in the presence of Hb, NO molecules rapidly and irreversibly bind to Hb to form HbNO, which is the intermediate in the nitric oxide metabolism. On the other hand, the reversible binding of the iron nitrosyl complex to the surface functional groups of Hb leads to a decrease in its concentration in a solution and deceleration of the formation of NO. Therefore, Hb can ensure the complete and more prolonged assimilation of NO. 相似文献
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