Automatic approximation using asymptotically optimal adaptive interpolation

Numerical Algorithms - We present an asymptotic analysis of adaptive methods for Lp approximation of functions f ∈ Cr([a, b]), where $1\le p\le +\infty $ . The methods rely on piecewise...     

Thermal properties of pressure sintered alumina–graphene composites

Journal of Thermal Analysis and Calorimetry - The work concerns the alumina–graphene materials sintered by two different pressure methods. The different particle sizes of graphene were used....     

Influence of the Degree of Deacetylation of Chitosan and BMP-2 Concentration on Biocompatibility and Osteogenic Properties of BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels

Compositions based on chitosan/β-glycerophosphate hydrogels with highly porous polylactide granules can be used to obtain moldable bone graft materials that have osteoinductive and osteoconductive properties. To eliminate the influence of such characteristics as chain length, degree of purification, and molecular weight on a designed material, the one-stock chitosan sample was reacetylated to degrees of deacetylation (DD%) of 19.5, 39, 49, 55, and 56. A study of the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD% showed that a low degree of deacetylation increased the MSCs (multipotent stromal cells) viability rate in vitro and reduced the leukocyte infiltration in subcutaneous implantation to Wistar rats in vivo. The addition of 12 wt% polylactide granules resulted in optimal composite mechanical and moldable properties, and increased the modulus of elasticity of the hydrogel-based material by approximately 100 times. Excessive filling of the material with PLA (polylactide) granules (more than 20%) led to material destruction at a ~10% strain. Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation. When implanted into a critical-size calvarial defect in rats, the optimal concentration of BMP-2 was 10 μg/mL: bone tissue areas filled the entire material’s thickness. Implantation of the material with 50 μg/mL BMP-2 was accompanied with excessive growth of bone tissue and material displacement beyond the defect. Significant osteoinductive and osteoconductive properties of the material with 10 μg/mL of BMP-2 were also shown in subcutaneous implantation.     

The representation dimension of domestic weakly symmetric algebras

Auslander’s representation dimension measures how far a finite dimensional algebra is away from being of finite representation type. In [1], M. Auslander proved that a finite dimensional algebra A is of finite representation type if and only if the representation dimension of A is at most 2. Recently, R. Rouquier proved that there are finite dimensional algebras of an arbitrarily large finite representation dimension. One of the exciting open problems is to show that all finite dimensional algebras of tame representation type have representation dimension at most 3. We prove that this is true for all domestic weakly symmetric algebras over algebraically closed fields having simply connected Galois coverings.     

On characterization of Poisson and Jacobi structures

We characterize Poisson and Jacobi structures by means of complete lifts of the corresponding tensors: the lifts have to be related to canonical structures by morphisms of corresponding vector bundles. Similar results hold for generalized Poisson and Jacobi structures (canonical structures) associated with Lie algebroids and Jacobi algebroids.     

Dynamic supercoiling bifurcations of growing elastic filaments

Certain bacteria form filamentous colonies when the cells fail to separate after dividing. In Bacillus subtilis, Bacillus thermus, and Cyanobacteria, the filaments can wrap into complex supercoiled structures as the cells grow. The structures may be solenoids or plectonemes, with or without branches in the latter case. Any microscopic theory of these morphological instabilities must address the nature of pattern selection in the presence of growth, for growth renders the problem nonautonomous and the bifurcations dynamic. To gain insight into these phenomena, we formulate a general theory for growing elastic filaments with bending and twisting resistance in a viscous medium, and study an illustrative model problem: a growing filament with preferred twist, closed into a loop. Growth depletes the twist, inducing a twist strain. The closure of the loop prevents the filament from unwinding back to the preferred twist; instead, twist relaxation is accomplished by the formation of supercoils. Growth also produces viscous stresses on the filament which even in the absence of twist produce buckling instabilities. Our linear stability analysis and numerical studies reveal two dynamic regimes. For small intrinsic twist the instability is akin to Euler buckling, leading to solenoidal structures, while for large twist it is like the classic writhing of a twisted filament, producing plectonemic windings. This model may apply to situations in which supercoils form only, or more readily, when axial rotation of filaments is blocked. Applications to specific biological systems are proposed.     

Information and asymptotic efficiency of the case-cohort sampling design in Cox's regression model

Efficiencies of the maximum pseudolikelihood estimator and a number of related estimators for the case-cohort sampling design in the proportional hazards regression model are studied. The asymptotic information and lower bound for estimating the parametric regression parameter are calculated based on the effective score, which is obtained by determining the component of the parametric score orthogonal to the space generated by the infinite-dimensional nuisance parameter. The asymptotic distributions of the maximum pseudolikelihood and related estimators in an i.i.d. setting show that these estimators do not achieve the computed asymptotic lower bound. Simple guidelines are provided to determine in which instances such estimators are close enough to efficient for practical purposes.     

Configurational and conformational preferences in stereoselective acylations of <Emphasis Type="Italic">N</Emphasis>-methyl-1,3-diaminopropane with acyl chlorides

Evidence for a stereoinduction profile of the reaction of N-methyl-1,3-diaminopropane with acyl chlorides has been provided. A possibility to engage in intramolecular CH₂⋯HN and Cl⋯H-N interactions and the proton migration process to the methylamino group leads to the E secondary amides carrying the N⋯H⁺⋯N or N-H⋯N bridges, that show unusual spectroscopic images. Empirical relations between the Δδ _C chemical shift differences, the polarizability of the CO(S) groups and hydrogen bonding strength have been found. Both ¹H-¹⁵N-GHSQC and GHMBC experiments provide insight into the nature of hydrogen bonding and confirm the cyclic array of atoms.     

Strongly countable dimensional compacta form the Hurewicz set

The hyperspaces of strongly countable dimensional compacta of positive dimension and of strongly countable dimensional continua of dimension greater than 1 in the Hilbert cube are homeomorphic to the Hurewicz set of all nonempty countable closed subsets of the unit interval [0,1]. These facts hold true, in particular, for covering dimension dim and cohomological dimension dimG, where G is any Abelian group.