排序方式: 共有41条查询结果,搜索用时 15 毫秒
1.
Andrii Lozynskyi Julia Senkiv Iryna Ivasechko Nataliya Finiuk Olga Klyuchivska Nataliya Kashchak Danylo Lesyk Andriy Karkhut Svyatoslav Polovkovych Oksana Levytska Olexandr Karpenko Assyl Boshkayeva Galiya Sayakova Andrzej Gzella Rostyslav Stoika Roman Lesyk 《Molecules (Basel, Switzerland)》2022,27(21)
A series of 11-substituted 3,5,10,11-tetrahydro-2H-benzo[6,7]thiochromeno[2,3-d][1,3]thiazole-2,5,10-triones were obtained via hetero-Diels-Alder reaction of 5-alkyl/arylallylidene/-4-thioxo-2-thiazolidinones and 1,4-naphthoquinones. The structures of newly synthesized compounds were established by spectral data and a single-crystal X-ray diffraction analysis. According to U.S. NCI protocols, compounds 3.5 and 3.6 were screened for their anticancer activity; 11-Phenethyl-3,11-dihydro-2H-benzo[6,7]thiochromeno[2,3-d]thiazole-2,5,10-trione (3.6) showed pronounced cytotoxic effect on leukemia (Jurkat, THP-1), epidermoid (KB3-1, KBC-1), and colon (HCT116wt, HCT116 p53-/-) cell lines. The cytotoxic action of 3.6 on p53-deficient colon carcinoma cells was two times weaker than on HCT116wt, and it may be an interesting feature of the mechanism action. 相似文献
2.
Danylo Kaminskyy Dmytro Khyluk Olexandr Vasylenko Roman Lesyk 《Tetrahedron letters》2012,53(5):557-559
The use of 3-substituted-2-mercaptoacrylic acids, synthesized via hydrolysis of 5-ylidenerhodanines for the preparation of 2,3,5-trisubstituted-4-thiazolidinones via a new variant of the one-pot, three-component reaction has been studied. 相似文献
3.
[reaction: see text] Acid chlorides and aromatic aldehydes react in the presence of a stoichiometric amount of a tertiary amine and catalytic amounts of a cinchona alkaloid derivative and a Lewis acid to produce beta-lactones in high diastereo- and enantioselectivity. The sense of the diastereoselectivity depends on the substitution of the acid chloride, with the reactions of aliphatic acid chlorides giving predominantly the trans-isomer and those of alkoxyacetyl chlorides favoring formation of the cis-isomer. 相似文献
4.
Andrii Lozynskyi Borys Zimenkovsky Iryna Ivasechko Julia Senkiv Andrzej Gzella Olexandr Karpenko 《Phosphorus, sulfur, and silicon and the related elements》2013,188(12):1149-1157
AbstractThe synthesis and anticancer activity evaluation of new thiazolo[4,5-b]pyridine-5-carboxylic acid amides is described. The structures of the synthesized compounds were confirmed by spectroscopic data and a single crystal X-ray diffraction analysis for 2.4. The synthesized compounds were screened for their in vitro anticancer activity according to US NCI protocols. The most active 7-(4-fluorophenyl)-2-oxo-2,3-dihydrothiazolo[4,5-b]pyridine-5-carboxylic acid (4-chlorophenyl)amide 2.2 and 7-(4-chlorophenyl)-2-oxo-2,3-dihydrothiazolo[4,5-b]pyridine-5-carboxylic acid (4-chlorophenyl)amide 2.5 were screened for their cytotoxicity effects on C6 Rat glioma cells and U373 Human glioblastoma astrocytoma cells which revealed promising results comparable to temozolamide as reference control according MTT assay data. 相似文献
5.
Nataliya Zelisko Dmytro Atamanyuk Olexandr Vasylenko Andriy Bryhas Vasyl Matiychuk Andrzej Gzella Roman Lesyk 《Tetrahedron》2014
Various novel thiopyrano[2,3-d][1,3]thiazol-2-one-6-carboxylic acids derivatives were synthesized in 54–86% yields via hetero-Diels–Alder reactions and related acylation-based tandem processes of 5-arylidene-4-thioxo-2-thiazolidinones with crotonic, propiolic, and cynnamic acids derivatives. Stereo- and regioselectivity of cycloaddition were investigated. 相似文献
6.
Fredholm boundary value problems for perturbed systems of dynamic equations on time scales 下载免费PDF全文
Ravi P. Agarwal Martin Bohner Alexandr Boı̆chuk Olexandr Strakh 《Mathematical Methods in the Applied Sciences》2015,38(17):4178-4186
This paper offers conditions ensuring the existence of solutions of linear boundary value problems for systems of dynamic equations on time scales. Utilizing a method of Moore–Penrose pseudo‐inverse matrices leads to an analytical form of a criterion for the existence of solutions in a relevant space and, moreover, to the construction of a family of linearly independent solutions of such problems in a general case with the number of boundary conditions (defined by a linear vector functional) not coinciding with the number of unknowns of a system of dynamic equations. As an example of an application of the presented results, the problem of bifurcation of solutions of boundary value problems for systems of dynamic equations on time scales with a small parameter is considered. 相似文献
7.
This paper describes symmetries of all integrable difference equations that belong to the famous Adler–Bobenko–Suris classification. For each equation, the characteristics of symmetries satisfy a functional equation, which we solve by reducing it to a system of partial differential equations. In this way, all five-point symmetries of integrable equations on the quad-graph are found. These include mastersymmetries, which allow one to construct infinite hierarchies of local symmetries. We also demonstrate a connection between the symmetries of quad-graph equations and those of the corresponding Toda type difference equations. 相似文献
8.
We study the structure of the semigroup IO n of all order-preserving partial bijections on an n-element set. For this semigroup we describe maximal subsemigroups, maximal inverse subsemigroups, automorphisms and maximal nilpotent subsemigroups. We also calculate the maximal cardinality for the nilpotent subsemigroups in IO n which happens to be given by the n-th Catalan number. 相似文献
9.
Sergii Golota Ivan Sydorenko Roman Surma Olexandr Karpenko Andrzej Gzella 《合成通讯》2017,47(11):1071-1076
A multicomponent synthetic approach for 5-aryl/heterylidene-2-(2-hydroxyethylamino)- and 2-(3-hydroxypropylamino)-thiazol-4-ones starting from 2-thioxothiazolidin-4-one or 2-methylsulfanylthiazol-4-one was developed. The proposed method involves simultaneous aminolysis of 2-thioxo- or 2-methylsulfanyl groups and Knoevenagel condensation with (hetero)aromatic aldehydes using 2-aminoethanol or 3-aminopropan-1-ol as catalysts. Side-chain prototropic amino–imino tautomerism was observed for target 5-ylidene-2-alkylaminothiazol-4-ones. 相似文献
10.
Tamara Bezrodna Georgyi Klishevich Volodymyr Melnyk Vira Nesprava Olexandr Roshchin 《Molecular Crystals and Liquid Crystals》2020,697(1):60-67
AbstractFluorescence and absorption spectra of the 2-fluoronaphthalene admixtures in naphthalene were studied at low temperature (T?=?4.2 К). Two types of pairwise impurity centers were formed at admixture concentrations of more than 1?wt%. Polarization of absorption bands was detected; these spectra were determined by resonance interactions between molecules of the impurity center. Resonant splitting of electronic levels for the translationally nonequivalent molecules in the unit cell of the naphthalene crystal was analyzed for the case, when one molecule was in the similar phase with the incident light wave and the other one was in antiphase. 相似文献