A Facile Synthesis of Fused Phosphorus-Heterocycle with Bioactivity via Lawesson's Reagent

A convenient one-pot synthesis of fused phosphorus-heterocycles with biological activity via the cyclization reactions of Lawesson's reagent with bifunctional substrates is reported.     

超声波辅助萃取同位素稀释质谱法测定聚氯乙烯中6种邻苯二甲酸酯

采用超声波辅助萃取同位素稀释质谱法测定聚氯乙烯中6种邻苯二甲酸酯的含量。以四氢呋喃为溶剂对样品进行超声波辅助提取后,加入甲醇对聚合物进行沉淀,取上清液,经冷冻离心后进行气相色谱一质谱分析,并采用氘代邻苯二甲酸酯为内标,单点校正法定量。该方法应用于中、日、韩计量比对的样品测定中,两天进行的6次测定结果相对标准偏差为0．7％～3．0％。最终比对结果显示3个国家的数据取得很好的一致性,除DEP相对标准偏差为2．4％以外,其它5种邻苯二甲酸酯相对标准偏差为0．7％～1．2％,测定结果的相对扩展不确定度为1．8％～4．9％,证明该方法准确、可靠。     

微机结构分析的现状与前景

本文回顾了16位微机上的通用结构分析系统近十年来国际、国内的发展概况,对未来十年微机结构分析的发展与前景提出了一些看法。在未来十年中,微机上的非线性结构分析将不仅成为可能,而且会成为计算力学主要的开发对象。非线性分析的求解器、分叉问题等非常棘手的问题,可望在未来十年中得到解决。多窗口图形系统等现代计算机技术将会使微机结构分析的用户界面增辉生色。     

Polyethylenimine‐Based Nanogels for Biomedical Applications

Nanogels (NGs) are 3‐dimensional (3D) networks composed of hydrophilic or amphiphilic polymer chains, allowing for effective and homogeneous encapsulation of drugs, genes, or imaging agents for biomedical applications. Polyethylenimine (PEI), possessing abundant positively charged amine groups, is an ideal platform for the development of NGs. A variety of effective PEI‐based NGs have been designed and much effort has been devoted to study the relationship between the structure and function of the NGs. In particular, PEI‐based NGs can be prepared either using PEI as the major NG component or using PEI as a crosslinker. This review reports the recent progresses in the design of PEI‐based NGs for gene and drug delivery and for bioimaging applications with a target focus to tackle the diagnosis and therapy of cancer.     

刻槽绝缘平行板对电子束的导向效应研究

采用不同材质的刻槽绝缘平行板,包括高纯度石英玻璃、聚四氟乙烯（Teflon）、酚醛树脂（电木）和聚甲醛板（赛钢板）,并在15 pA/mm2 ~14.3 nA/mm2范围内改变入射流强,利用1 500 eV电子束入射上述绝缘平行板,实验研究了上述平行板对电子束的导向行为。实验发现,上述电子束通过上述平行板时存在明显的导向现象,其导向行为与束流流强和绝缘材质无关。据此,可排除绝缘平行板内表面沉积电荷自组织充放电过程中,以绝缘材料的面电阻和体电阻对地泄放的线性形式放电过程。Adopting several grooved parallel plates made by different insulators, such as high-purity fused quartz, Teflon, Bakelite and POM (Polyformaldehyde), and further adjusting the electron beam current in a wide range (tens of pA~tens of nA), the discharging mechanism in the self-organizing charge and discharge processes of electron guiding was investigated and discussed by using 1 500 eV incident electron beam. The present results show that, the electron guiding behaviors are obviously existing when such electron beam is transmitted through the above grooved insulating parallel plates, which are independent on beam current and insulators. Our results suggest that, the possibilities of the accumulated charges on inner-surface of grooved parallel plates linearly discharging through surface and bulk resistances of plates into the ground should be excluded.     

CYCIAE型回旋加速器负离子剥离引出的光学行为研究

为了CYCIAE型回旋加速器的剥离靶轴线及旋转角的概念设计,必须对负离子剥离后的光学特性进行研究,基于根据CYCIAE型回旋加速器剥离引出特点编制的程序CYCRS,计算了CYCIAE30加速器不同能量束流引出剥离点的位置,并与实际位置进行比较,证明计算所用的理论及方法是正确的,同时,考察了剥离后的束流空间运动的光学特性.在此基础上,确定了CYCIAE70回旋加速器能量为35—70MeV的束流引出剥离点位置.     

Thickness determination of molecularly thin lubricant films by angle-dependent X-ray photoelectron spectroscopy

An angle-dependent X-ray photoelectron spectroscopy (XPS) method used to measure the thickness of molecularly thin lubricants was developed. The method was built based on an island model of patched overlayer on a flat substrate by using the photoemission signal solely from the lubricant film. Typical molecularly thin Zdol films on the CHx overcoat of unused commercial magnetic disks were measured to verify the metrology. The lubricant thickness determined by the metrology was equal to the recent result by thermostatic high vacuum atomic force microscopy. The measured deduction in the thickness of the molecularly thin lubricant films, successively irradiated by the monochromatic source operated at 14 kV/250 W, was as low as 1 ? during the first irradiation hour. XPS spectra showed that no hydrocarbons, water or oxygen were adsorbed over the Zdol outer surfaces in the tested XPS conditions. The inelastic mean free path (IMFP) of C 1s in Zdol or in CHx was found to be independent of take off angle (TOA) when TOA < 40°. The IMFP of C 1s in Zdol was ∼63.5 ? and the lubricant island thickness was ∼35 ?.     

血清中葡萄糖含量CCQM-K11.1国际比对

研究利用同位素稀释质谱法测定血清中的葡萄糖含量,并利用该方法参加国际物质量咨询委员会（CCQM）2005年组织的关键比对CCQM—K11．1,我国国家标准物质研究中心（NRCCRM）的测定结果与韩国（KRISS）和墨西哥（CENAM）的测定结果非常接近,日本（NMIJ）的测定结果离群偏高。     

Improved cellular response on multiwalled carbon nanotube-incorporated electrospun polyvinyl alcohol/chitosan nanofibrous scaffolds

We report the fabrication of multiwalled carbon nanotube (MWCNT)-incorporated electrospun polyvinyl alcohol (PVA)/chitosan (CS) nanofibers with improved cellular response for potential tissue engineering applications. In this study, smooth and uniform PVA/CS and PVA/CS/MWCNTs nanofibers with water stability were formed by electrospinning, followed by crosslinking with glutaraldehyde vapor. The morphology, structure, and mechanical properties of the formed electrospun fibrous mats were characterized using scanning electron microscopy, Fourier transform infrared spectroscopy, and mechanical testing, respectively. We showed that the incorporation of MWCNTs did not appreciably affect the morphology of the PVA/CS nanofibers; importantly the protein adsorption ability of the nanofibers was significantly improved. In vitro cell culture of mouse fibroblasts (L929) seeded onto the electrospun scaffolds showed that the incorporation of MWCNTs into the PVA/CS nanofibers significantly promoted cell proliferation. Results from this study hence suggest that MWCNT-incorporated PVA/CS nanofibrous scaffolds with small diameters (around 160 nm) and high porosity can mimic the natural extracellular matrix well, and potentially provide many possibilities for applications in the fields of tissue engineering and regenerative medicine.