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1.
Summary The separation and quantitative determination of diphenylamine and its mono-derivatives in single-base gun propellants during
aging was investigated by High Performance Liquid Chromatography (HPLC). We have defined optimal conditions to allow determination
of diphenylamine and its mono-derivatives during aging until their levels fell below limits of detection.
These compounds were determined in a single-base gun propellant during a storage period of 168 hours at 100°C using a developed,
successfully verified HPLC method. 相似文献
2.
Baosić R Radojević A Radulović M Miletić S Natić M Tesić Z 《Biomedical chromatography : BMC》2008,22(4):379-386
The lipophilicity of a series of Schiff base ligands and their complexes with nickel(II) and copper(II) has been determined by reversed-phase thin-layer chromatography using binary dioxane-water mobile phase. Chelate ligands were prepared by condensation of diamine and the corresponding beta-diketone. Copper(II) and nickel(II) complexes with chelate ligands containing ethane-1,2-diamine or propane-1,2-diamine as the amine part and pentane-2,4-dione and/or 1-phenylbutane-1,3-dione, pentane-2,4-dione and/or 1,1,1-trifluoropentane-2,4-dione, or 1,1,1-trifluoropentane-2,4-dione and/or 1-phenylbutane-1,3-dione as the beta-diketone part were synthesized. Some of investigated compounds were screened for their in vitro antifungal activity against Sacharomyces cerevisiae and antibacterial activity against Escherichia coli. Chromatographically obtained lipophilicity parameters were correlated both with calculated n-octanol-water partition coefficient C log P and antimicrobial activities. Satisfactory correlations were obtained. Chromatographic data proved to be reliable parameters for describing the lipophilic properties of the investigated compounds. Additionally, the principal components analysis was performed on the data chromatographically obtained. This statistical method was useful for distinguishing compounds and objective comparison of their lipophilicity parameters. 相似文献
3.
J. M. Filipovic D. M. Petrovic-Djakov Lj. P. Vrhovac J. S. Velickovic 《Journal of Thermal Analysis and Calorimetry》1993,40(2):735-740
The free radical copolymerization of phenyl methacrylate (PhMA) witho-methylphenyl-methacrylate(o-MPhMA) ando-ethylphenyl methacrylate (o-EPhMA) was carried out and the enthalpies of copolymerization, overall rate constants and copolymerization parameters were determined for different molar ratios of comonomers in the temperature range 353–373 K. 相似文献
4.
Zoran Marković Jelena Đorović Milan Dekić Milanka Radulović Svetlana Marković Marija Ilić 《Chemical Papers》2013,67(11):1453-1461
Antioxidant activity of erodiol was examined at the M05-2X/6-311+G(d,p) level of theory in the gas and aqueous phases. The structure and energy of radicals and anions of the most stable erodiol rotamer were analyzed. To estimate antioxidant potential of erodiol, different molecular properties were examined: bond dissociation enthalpy, proton affinity together with electron transfer energy, and ionization potential followed by proton dissociation enthalpy. It was found that hydrogen atom transfer is the prevailing mechanism of erodiol behavior in gas; whereas single electron transfer followed by proton transfer and sequential proton loss electron transfer mechanisms represent the thermodynamically preferred reaction paths in water. 相似文献
5.
Dr. Dehui Zhang Igor Macinkovic Dr. Nelmi O. Devarie‐Baez Dr. Jia Pan Dr. Chung‐Min Park Prof. Kate S. Carroll Dr. Milos R. Filipovic Prof. Ming Xian 《Angewandte Chemie (International ed. in English)》2014,53(2):575-581
Protein S‐sulfhydration (forming ‐S‐SH adducts from cysteine residues) is a newly defined oxidative posttranslational modification and plays an important role in H2S‐mediated signaling pathways. In this study we report the first selective, “tag‐switch” method which can directly label protein S‐sulfhydrated residues by forming stable thioether conjugates. Furthermore we demonstrate that H2S alone cannot lead to S‐sulfhydration and that the two possible physiological mechanisms include reaction with protein sulfenic acids (P‐SOH) or the involvement of metal centers which would facilitate the oxidation of H2S to HS.. 相似文献
6.
M. Sc. Hanna Pieper Dr. Serghei Chercheja Dr. Siegfried Eigler M. Sc. Christian E. Halbig Dr. Milos R. Filipovic Prof. Dr. Andriy Mokhir 《Angewandte Chemie (International ed. in English)》2016,55(1):405-407
Potential biomedicinal applications of graphene oxide (GO), for example, as a carrier of biomolecules or a reagent for photothermal therapy and biosensing, are limited by its cytotoxicity and mutagenicity. It is believed that these properties are at least partially caused by GO‐induced oxidative stress in cells. However, it is not known which chemical fragments of GO are responsible for this unfavorable effect. We generated four GOs containing variable redox‐active groups on the surface, including Mn2+, C‐centered radicals, and endoperoxides (EPs). A comparison of the abilities of these materials to generate reactive oxygen species in human cervical cancer cells revealed that EPs play a crucial role in GO‐induced oxidative stress. These data could be applied to the rational design of biocompatible nontoxic GOs for biomedical applications. 相似文献
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8.
提出了一种确定切换系统稳定性分析的方法.引入了两个相关的实例(非完整系统和约束摆)进行说明.用有限个模型的集合组成非线性模型,且切换序列可以是任意的.假定在切换瞬间状态不出现跳跃,并且不出现Zeno现象,即在每个有界时间段上,切换次数是有限的.在对所确定切换系统的分析中,应用了多次Liapunov函数,并证明了全局指数稳定性.系统的指数稳定性平衡关系到实际应用,因为这样的系统有着更强健的抗干扰能力. 相似文献
9.
Mike Lange Kiwon Ok Geoffrey D. Shimberg Biljana Bursac Lajos Mark Ivana Ivanovi‐Burmazovi Sarah L. J. Michel Milos R. Filipovic 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(24):8081-8085
H2S is a gaseous signaling molecule that modifies cysteine residues in proteins to form persulfides (P‐SSH). One family of proteins modified by H2S are zinc finger (ZF) proteins, which contain multiple zinc‐coordinating cysteine residues. Herein, we report the reactivity of H2S with a ZF protein called tristetraprolin (TTP). Rapid persulfidation leading to complete thiol oxidation of TTP mediated by H2S was observed by low‐temperature ESI‐MS and fluorescence spectroscopy. Persulfidation of TTP required O2 , which reacts with H2S to form superoxide, as detected by ESI‐MS, a hydroethidine fluorescence assay, and EPR spin trapping. H2S was observed to inhibit TTP function (binding to TNFα mRNA) by an in vitro fluorescence anisotropy assay and to modulate TNFα in vivo. H2S was unreactive towards TTP when the protein was bound to RNA, thus suggesting a protective effect of RNA. 相似文献
10.
David Strelak Amaya Jimnez-Moreno Jos L. Vilas Erney Ramírez-Aportela Ruben Snchez-García David Maluenda Javier Vargas David Herreros Estrella Fernndez-Gimnez Federico P. de Isidro-Gmez Jan Horacek David Myska Martin Horacek Pablo Conesa Yunior C. Fonseca-Reyna Jorge Jimnez Marta Martínez Mohamad Harastani Slavica Joni Jiri Filipovic Roberto Marabini Jos M. Carazo Carlos O. S. Sorzano 《Molecules (Basel, Switzerland)》2021,26(20)
Xmipp is an open-source software package consisting of multiple programs for processing data originating from electron microscopy and electron tomography, designed and managed by the Biocomputing Unit of the Spanish National Center for Biotechnology, although with contributions from many other developers over the world. During its 25 years of existence, Xmipp underwent multiple changes and updates. While there were many publications related to new programs and functionality added to Xmipp, there is no single publication on the Xmipp as a package since 2013. In this article, we give an overview of the changes and new work since 2013, describe technologies and techniques used during the development, and take a peek at the future of the package. 相似文献