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排序方式: 共有64条查询结果,搜索用时 15 毫秒
1.
Luigia Serpico Mauro De Nisco Flavio Cermola Michele Manfra Silvana Pedatella 《Molecules (Basel, Switzerland)》2021,26(9)
A simple and efficient route for the synthesis of new glycoconjugates has been developed. The approach acts as a model for a mini-library of compounds with a deoxy-selenosugar core joined to a polyphenolic moiety with well-known antioxidant properties. An unexpected stereocontrol detected in the Mitsunobu key reaction led to the most attractive product showing a natural d-configuration. Thus, we were able to obtain the target molecules from the commercially available d-ribose via a shorter and convenient sequence of reactions. 相似文献
2.
3.
The people and places of importance to the history of chemistry in Italy have been reviewed with particular reference to Analytical
Chemistry.
Correspondence: D. Thorburn Burns, The Science Library, The Queen’s University of Belfast, Belfast BT9 5EQ, Northern Ireland 相似文献
4.
Dr. Kyriaki Manoli Dr. Maria Magliulo Dr. Mohammad Yusuf Mulla M. Sc. Mandeep Singh Prof. Luigia Sabbatini Prof. Gerardo Palazzo Prof. Luisa Torsi 《Angewandte Chemie (International ed. in English)》2015,54(43):12562-12576
Thin‐film transistors can be used as high‐performance bioelectronic devices to accomplish tasks such as sensing or controlling the release of biological species as well as transducing the electrical activity of cells or even organs, such as the brain. Organic, graphene, or zinc oxide are used as convenient printable semiconducting layers and can lead to high‐performance low‐cost bioelectronic sensing devices that are potentially very useful for point‐of‐care applications. Among others, electrolyte‐gated transistors are of interest as they can be operated as capacitance‐modulated devices, because of the high capacitance of their charge double layers. Specifically, it is the capacitance of the biolayer, being lowest in a series of capacitors, which controls the output current of the device. Such an occurrence allows for extremely high sensitivity towards very weak interactions. All the aspects governing these processes are reviewed here. 相似文献
5.
Michele Menotta Sara Biagiotti Laura Streppa Luigia Rossi Mauro Magnani 《Analytica chimica acta》2015
In the present paper we describe an atomic force microscopy (AFM)-based method for the quantitative analysis of FK506 (Tacrolimus) in whole blood (WB) samples. Current reference methods used to quantify this immunosuppressive drug are based on mass spectrometry. In addition, an immunoenzymatic assay (ELISA) has been developed and is widely used in clinic, even though it shows a small but consistent overestimation of the actual drug concentration when compared with the mass spectrometry method. The AFM biosensor presented herein utilises the endogen drug receptor, FKBP12, to quantify Tacrolimus levels. The biosensor was first assayed to detect the free drug in solution, and subsequently used for the detection of Tacrolimus in blood samples. The sensor was suitable to generate a dose–response curve in the full range of clinical drug monitoring. A comparison with the clinically tested ELISA assay is also reported. 相似文献
6.
Luigia Di Terlizzi 《Mediterranean Journal of Mathematics》2006,3(3-4):533-547
We consider a Riemannian manifold (M,g) equipped with an f-structure of constant rank with parallelizable kernel. We assume certain integrability conditions on
such a manifold. We prove some inequalities involving the scalar and *-scalar curvature of g. We prove that the corresponding equalities characterize an
-manifold, which is a generalization of a Sasakian manifold. We also give a method of constructing such structures on toroidal
bundles.
Dedicated to the memory of Professor Aldo Cossu
Research supported by the Italian MIUR 60% and GNSAGA. 相似文献
7.
Longo L Vasapollo G Guascito MR Malitesta C 《Analytical and bioanalytical chemistry》2006,385(1):146-152
A three-step process for immobilization of glutamate dehydrogenase (GDH) on the surface of silicon dioxide has been studied
by X-ray photoelectron spectroscopy (XPS). The enzyme layer was deposited on the silicon dioxide surface after first exposing
the surface to 3-aminopropyltriethoxysilane (3-APTS) and reacting the silylated surface with glutaraldehyde (GA). Fine XPS
analysis, performed after each step of the chemical procedure, revealed unknown details of the step-by-step construction of
the enzyme layer under different experimental conditions. 相似文献
8.
Giuseppe E. De Benedetto Silvia Nicolì Antonio Pennetta Daniela Rizzo Luigia Sabbatini Annarosa Mangone 《Journal of Raman spectroscopy : JRS》2011,42(6):1317-1323
Painted Canosa ceramics were examined to identify the nature of the pigments employed and their manufacturing technology. A multi‐technique approach was used, comprising Raman microspectroscopy and laser ablation hyphenated to inductively coupled plasma‐mass spectrometry (LA‐ICP‐MS). The analysed samples were mainly produced for burial in tombs and were not intended for everyday use. They belong to the period between the end of the mid‐7th century and the first half of the 4th century BC, and were excavated from the Toppicelli archaeological district near the suburbs of Canosa (Puglia, Italy). Forty‐eight pottery fragments were available for this study. No handling of the samples was required for the Raman study, and it was possible to excise the pigmented layer in such a way that the lacunae were not distinguishable to the naked eye due to the micrometric size of the laser spot as far as LA‐ICP‐MS is concerned. Their combination turned out to be quite useful for the investigation of these archaeological materials: the chemical nature of the white, red, brown and black pigments employed in the pottery manufacture was investigated. Iron and manganese compounds were identified as the red and brown/black main colouring substances, respectively; on the other hand, whites and engobes (whitish slips) were based on kaolinite. This set of colouring substances is of importance, as it enabled the artisan to obtain in one oxidising firing cycle brown, black and red paints. Finally, the finding of manganese black in these Canosa potsherds confirms that Canosa was an important centre connecting the near East to central Italy and Europe since the pre‐Roman age. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
9.
Zotti M Schiavone S Tricarico F Colaianna M D'Apolito O Paglia G Corso G Trabace L 《Journal of separation science》2008,31(13):2511-2515
Nitric oxide (NO) is one of the most important mediators and neurotransmitters and its levels change under pathological conditions. NO production may be regulated by endogenous nitric oxide synthase (NOS) inhibitors, in particular asymmetric dimethylarginine (ADMA). Most of the interest is focused on ADMA, since this compound is present in plasma and urine and accumulation of ADMA has been described in many disease states but little is known about cerebrospinal fluid (CSF) concentrations of this compound and of its structural isomer symmetric dimethylarginine (SDMA). To determine the levels of methylarginines, we here present a new hydrophilic interaction chromatography (HILIC)-MS/MS method for the precise determination of these substances in CSF from microdialysis samples of rat prefrontal cortex (PFC). The method requires only minimal sample preparation and features isotope-labelled internal standards. 相似文献
10.