Structure and Mechanical Properties of a Dispersedly Filled Transparent Polycarbonate

Mechanics of Composite Materials - The structure and mechanical properties of a composition on the basic of polycarbonate filled with three types of dispersed particles (submicron corundum, micron...     

Manganite Pr0.7Ca0.3MnO3 films obtained by extraction pyrolysis

The magnetic properties of manganite Pr_0.7Ca_0.3MnO₃ films, obtained for the first time by the extraction pyrolysis method, have been investigated. The effect of the synthesis temperature of the magnetic properties of the manganite films is demonstrated.     

Status of the Baikal neutrino project

The status of the Baikal neutrino experiment is briefly reviewed and the results of the search for the natural flux of high-energy neutrinos are reported.     

Powerful Potential of Polyfluoroalkyl-Containing 4-Arylhydrazinylidenepyrazol-3-ones for Pharmaceuticals

4-Arylhydrazinylidene-5-(polyfluoroalkyl)pyrazol-3-ones (4-AHPs) were found to be obtained by the regiospecific cyclization of 2-arylhydrazinylidene-3-(polyfluoroalkyl)-3-oxoesters with hydrazines, by the azo coupling of 4-nonsubstituted pyrazol-5-oles with aryldiazonium chlorides or by the firstly discovered acid-promoted self-condensation of 2-arylhydrazinylidene-3-oxoesters. All the 4-AHPs had an acceptable ADME profile. Varying the substituents in 4-AHPs promoted the switching or combining of their biological activity. The polyfluoroalkyl residue in 4-AHPs led to the appearance of an anticarboxylesterase action in the micromolar range. An NH-fragment and/or methyl group instead of the polyfluoroalkyl one in the 4-AHPs promoted antioxidant properties in the ABTS, FRAP and ORAC tests, as well as anti-cancer activity against HeLa that was at the Doxorubicin level coupled with lower cytotoxicity against normal human fibroblasts. Some Ph-N-substituted 4-AHPs could inhibit the growth of N. gonorrhoeae bacteria at MIC 0.9 μg/mL. The possibility of using 4-AHPs for cell visualization was shown. Most of the 4-AHPs exhibited a pronounced analgesic effect in a hot plate test in vivo at and above the diclofenac and metamizole levels except for the ones with two chlorine atoms in the aryl group. The methylsulfonyl residue was proved to raise the anti-inflammatory effect also. A mechanism of the antinociceptive action of the 4-AHPs through blocking the TRPV1 receptor was proposed and confirmed using in vitro experiment and molecular docking.     

Influence of the Thickness of a Polymer Shell Applied to Surfaces of Submicron Filler Particles on the Properties of Polymer Compositions

Mechanics of Composite Materials - The results of studies into the influence of the thickness of a polystyrene shell applied to surfaces of dispersed corundum (Al2O3) filler particles on the...     

Synthesis,Phosphonylation, and Anti-Viral Activity of Some 6-Aryl-5-cyano-2-thiouracils

Russian Journal of General Chemistry - A series of 6-aryl-5-cyano-2-thiouracils was synthesized, the reaction of which with diethyl chloroethynylphosphonate leads to the selective formation of new...