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LC/MS/MS analysis of α‐tocopherol and coenzyme Q10 content in lyophilized royal jelly,beebread and drone homogenate
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Marta Hryniewicka Agnieszka Karpinska Marta Kijewska Monika Joanna Turkowicz Joanna Karpinska 《Journal of mass spectrometry : JMS》2016,51(11):1023-1029
This study shows the results of application liquid chromatography‐tandem mass spectrometry (LC/MS/MS) for assay of the content of α‐tocopherol and coenzyme Q10 in bee products of animal origin, i.e. royal jelly, beebread and drone homogenate. The biological matrix was removed using extraction with n‐hexane. It was found that drone homogenate is a rich source of coenzyme Q10. It contains only 8 ± 1 µg/g of α‐tocopherol and 20 ± 2 µg/g of coenzyme Q10. The contents of assayed compounds in royal jelly were 16 ± 3 and 8 ± 0.2 µg/g of α‐tocopherol and coenzyme Q10, respectively. Beebread appeared to be the richest of α‐tocopherol. Its level was 80 ± 30 µg/g, while the level of coenzyme Q10 was only 11.5 ± 0.3 µg/g. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
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We investigate the finer fractal structure of the set of pointsescaping to infinity under iteration of an arbitrary exponentialmap. Providing exact formulas, we show how sensitively the Hausdorffdimension depends on the rate of growth of canonical DevaneyKrychcodes. 相似文献
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Eamonn JoycePaul Kavanagh Dónal LeechJolanta Karpinska Patrick McArdleFawaz Aldabbagh 《Tetrahedron letters》2012,53(29):3788-3791
Acetic anhydride mediates a facile and rapid condensation of benzimidazole with aromatic o-diacid dichlorides to precipitate p-dione adducts in excellent yields. Condensation with pyridine-3,4-dicarbonyl dichloride produced a 1:1 mixture of isomeric p-diones. The X-ray crystal structure of one of the latter isomers revealed unusual high density, and inter-layer separation similar to graphite. Cyclic voltammetry demonstrated that p-dione is capable of two consecutive one-electron-reductions with formal potentials influenced by the fused (hetero)aromatic and substituent effects. 相似文献
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Karpinska K Cieplak MZ Guha S Malinowski A Skoskiewicz T Plesiewicz W Berkowski M Boyce B Lemberger TR Lindenfeld P 《Physical review letters》2000,84(1):155-158
Measurements of the resistivity, magnetoresistance, and penetration depth were made on films of La1.85Sr0.15CuO4, with up to 12 at. % of Zn substituted for the Cu. The results show that the quadratic temperature dependence of the inverse square of the penetration depth, indicative of d-wave superconductivity, is not affected by doping. The suppression of superconductivity leads to a metallic nonsuperconducting phase, as expected for a pairing mechanism related to spin fluctuations. The metal-insulator transition occurs in the vicinity of k(F)l approximately 1, and appears to be disorder driven, with the carrier concentration unaffected by doping. 相似文献
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Natalia Kleczewska Pawel J. Sikorski Zofia Warminska Lukasz Markiewicz Renata Kasprzyk Natalia Baran Karina Kwapiszewska Aneta Karpinska Jaroslaw Michalski Robert Holyst Joanna Kowalska Jacek Jemielity 《Chemical science》2021,12(30):10242
Targeting cap-dependent translation initiation is one of the experimental approaches that could lead to the development of novel anti-cancer therapies. Synthetic dinucleoside 5′,5′-triphosphates cap analogs are potent antagonists of eukaryotic translation initiation factor 4E (eIF4E) in vitro and could counteract elevated levels of eIF4E in cancer cells; however, transformation of these compounds into therapeutic agents remains challenging – they do not easily penetrate into cells and are susceptible to enzymatic cleavage. Here, we tested the potential of several small molecule ligands – folic acid, biotin, glucose, and cholesterol – to deliver both hydrolyzable and cleavage-resistant cap analogs into cells. A broad structure–activity relationship (SAR) study using model fluorescent probes and cap–ligand conjugates showed that cholesterol greatly facilitates uptake of cap analogs without disturbing the interactions with eIF4E. The most potent cholesterol conjugate identified showed apoptosis-mediated cytotoxicity towards cancer cells.Ligand assisted cellular delivery of negatively charged dinucleotides, which are potential antagonists of the protooncogenic protein eIF4E. 相似文献
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