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排序方式: 共有103条查询结果,搜索用时 500 毫秒
1.
Morris SM Pipkin JL Hinson WG Shaddock JG Tolleson WH Young JF Casciano DA 《Electrophoresis》2001,22(10):2092-2097
In a previous study, the strength of the interaction between the nuclear stress proteins (sps) 25a, 70i, 72c, and 90 and the tumor suppressor protein p53 was determined by an in vitro fluorescence binding assay. The relative binding of the individual sps with p53, derived from the bone marrow of transgenic mice heterozygous at the p53 locus (p53+/-), was reduced compared to the interaction of sps and p53 derived from wild-type (p53+/+) mice. In order to determine if the genotype of the p53 donor or the genotype of the sp donor determined the binding efficiency, p53 expression was induced by retinoic acid and sp synthesis by bleomycin. P53 derived from either wild-type or heterozygous animals was cross-reacted with nuclear sps obtained from either wild-type or heterozygous animals. Each of the sps, 25a, 70i, 72c, and 90, bound to wild-type p53 with a similar efficiency, irrespective of the genotype of the sp donor mouse (p53+/+ or p53+/-). In contrast, when the sp interaction with p53 obtained from the heterozygous mouse was measured, the relative value of the fluorescence complex was significantly reduced. The data suggest that the strength of the interaction between p53 and nuclear sps is related to the genotype of the p53 donor, and not to the genotype of the animals from which the sps are derived. 相似文献
2.
Edwards KW Ogg M Bellerive A Britton DI Hyatt ER MacFarlane DB Patel PM Spaan B Sadoff AJ Ammar R Baringer P Bean A Besson D Coppage D Copty N Davis R Hancock N Kelly M Kotov S Kravchenko I Kwak N Lam H Kubota Y Lattery M Momayezi M Nelson JK Patton S Poling R Savinov V Schrenk S Wang R Alam MS Kim IJ Ling Z Mahmood AH O'Neill JJ Severini H Sun CR Wappler F Crawford G Daubenmier CM Fulton R Fujino D Gan KK Honscheid K Kagan H Kass R Lee J Sung M White C Wolf A Zoeller MM Butler F Fu X Nemati B 《Physical review letters》1995,74(17):3331-3335
3.
Casey L. Sayre Mandi Hopkins Jody K. Takemoto Neal M. Davies 《Biomedical chromatography : BMC》2013,27(3):404-406
Pharmacometric characterization studies of liquiritigenin have historically overlooked its chiral nature. To achieve complete characterization, an analytical method enabling the detection and quantification of the individual enantiomers of racemic (±) liquiritigenin is necessary. Resolution of the enantiomers of liquiritigenin was achieved using a simple high‐performance liquid chromatographic method. A Chiralpak® ADRH column was employed to perform baseline separation with UV detection at 210 nm.The standard curves were linear ranging from 0.5 to 100 µg/mL for each enantiomer. Limit of quantification was 0.5 µg/mL. The assay was applied successfully to stereoselective serum disposition of liquiritigenin enantiomers in rats. Liquiritigenin enantiomers were detected in serum as both aglycones and glucuronidated conjugates. Both unconjugated enantiomers had a serum half‐life of ~15 min in rats. The volume of distribution (Vd) for S‐ and R‐liquiritigenin was 1.49 and 2.21 L/kg, respectively. Total clearance (Cltotal) was 5.12 L/h/kg for S‐liquiritigenin and 4.79 L/h/kg for R‐liquiritigenin, and area under the curve (AUC0‐inf) was 3.95 µg h/mL for S‐liquiritigenin and 4.23 µg h/mL for R‐liquiritigenin. The large volume of distribution coupled with the short serum half‐life suggests extensive distribution of liquiritigenin into tissues. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
4.
Chiral analytical method development and application to pre‐clinical pharmacokinetics of pinocembrin
Casey L. Sayre Jody K. Takemoto Stephanie E. Martinez Neal M. Davies 《Biomedical chromatography : BMC》2013,27(6):681-684
An analytical method enabling the detection and quantification of the individual enantiomers of racemic (±) pinocembrin is required to fully characterize its pharmacokinetic disposition. Direct resolution of the enantiomers of pinocembrin was achieved using a novel and simple reversed‐phase high‐performance liquid chromatography method with electrospray ionization and detection by mass spectrometry in rat serum. A Chiralcel® AD‐RH column was employed to perform baseline separation with electrospray positive‐mode ionization with selected ion monitoring detection. The standard curves were linear from 0.5 to 100 µg/mL for each enantiomer. The limit of quantification was 0.5 µg/mL. The assay was applied successfully to stereoselective serum disposition of pinocembrin enantiomers in rats. Pinocembrin enantiomers were detected in serum. Both enantiomers had a serum half‐life of ~15 min in rats. Similar values of volume of distribution between the enantiomers were also observed: 1.76 L/kg for S‐pinocembrin and 1.79 L/kg for R‐pinocembrin. Total clearance was 5.527 L//h/kg for S‐pinocembrin and 5.535 L/h/kg for R‐pinocembrin, and the area under the curve was 1.821 µg h/mL for S‐pinocembrin and 1.876 µg h/mL for R‐pinocembrin. The large volume of distribution coupled with the short serum half‐life suggests extensive distribution of pinocembrin into the tissues. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
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6.
Video is commonly used in teacher preparation programs. Teacher educators use video for various purposes. In this study, we describe the Learning to Learn from Mathematics Teaching project. In this project, video is used to develop pre-service teachers’ (PSTs) orientations, knowledge and skills for analyzing and reflecting on mathematics teaching in ways that generate knowledge for improvement. We discuss the ways we have used video in a course aimed at developing elementary PSTs’ abilities to learn from teaching. In addition, we report on a study that investigated PSTs’ changes in lesson analysis abilities as a result of participating in the course. 相似文献
7.
Muramatsu H Richichi SJ Severini H Skubic P Dytman SA Mueller JA Nam S Savinov V Chen S Hinson JW Lee J Miller DH Pavlunin V Shibata EI Shipsey IP Cronin-Hennessy D Lyon AL Park CS Park W Thorndike EH Coan TE Gao YS Liu F Maravin Y Narsky I Stroynowski R Artuso M Boulahouache C Bukin K Dambasuren E Khroustalev K Mountain R Nandakumar R Skwarnicki T Stone S Wang JC Mahmood AH Csorna SE Danko I Bonvicini G Cinabro D Dubrovin M McGee S Bornheim A Lipeles E Pappas SP Shapiro A Sun WM Weinstein AJ 《Physical review letters》2002,89(25):251802
In e(+)e(-) collisions using the CLEO detector, we have studied the decay of the D0 to the final state K(0)(S)pi(+)pi(-) with the initial flavor of the D0 tagged by the decay D(*+)-->D0pi(+). We use the Dalitz technique to measure the resonant substructure in this final state and clearly observe ten different contributions by fitting for their amplitudes and relative phases. We observe a K(*)(892)(+)pi(-) component which arises from doubly Cabibbo suppressed decays or D0-D0; mixing. 相似文献
8.
Eckhart E Gan KK Gwon C Hart T Honscheid K Hufnagel D Kagan H Kass R Pedlar TK Thayer JB Von Toerne E Wilksen T Zoeller MM Muramatsu H Richichi SJ Severini H Skubic P Dytman SA Mueller JA Nam S Savinov V Chen S Hinson JW Lee J Miller DH Pavlunin V Shibata EI Shipsey IP Cronin-Hennessy D Lyon AL Park CS Park W Thorndike EH Coan TE Gao YS Liu F Maravin Y Stroynowski R Artuso M Boulahouache C Bukin K Dambasuren E Khroustalev K Mountain R Nandakumar R Skwarnicki T Stone S Wang JC Mahmood AH 《Physical review letters》2002,89(25):251801
We report on a search for charmless hadronic B decays to the three-body final states K(0)(S)h(+)pi(-), K(+)h(-)pi(0), K(0)(S)h(+)pi(0) (h(+/-) denotes a charged pion or kaon), and their charge conjugates, using 13.5 fb(-1) of integrated luminosity produced near sqrt[s]=10.6 GeV, and collected with the CLEO detector. We observe the decay B-->K0pi(+)pi(-) with a branching fraction (50(+10)(-9)(stat.)+/-7(syst.))x10(-6) and the decay B-->K(*+)(892)pi(-) with a branching fraction (16(+6)(-5)(stat.)+/-2(syst.))x10(-6). 相似文献
9.
Hinson JW Huang GS Lee J Miller DH Pavlunin V Rangarajan R Sanghi B Shibata EI Shipsey IP Cronin-Hennessy D Park CS Park W Thayer JB Thorndike EH Coan TE Gao YS Liu F Stroynowski R Artuso M Boulahouache C Blusk S Dambasuren E Dorjkhaidav O Mountain R Muramatsu H Nandakumar R Skwarnicki T Stone S Wang JC Csorna SE Danko I Bonvicini G Cinabro D Dubrovin M McGee S Bornheim A Lipeles E Pappas SP Shapiro A Sun WM Weinstein AJ Briere RA Chen GP Ferguson T Tatishvili G Vogel H Watkins ME Adam NE 《Physical review letters》2005,94(19):191801
Using the CLEO detector at the Cornell Electron Storage Ring, we have studied the distribution of kinematic variables in the decay lambda(+)(c)lambda--> e(+)nu(e). By performing a four-dimensional maximum likelihood fit, we determine the form factor ratio, R= f(2)/f(1) = -0.31 +/- 0.05(stat) +/- 0.04(syst), the pole mass, M(pole) = [2.21 +/- 0.08(stat) +/- 0.14(syst)] GeV/c(2), and the decay asymmetry parameter of the lambda(+)(c), alpha (lambda(c)) = -0.86 +/-0.03(stat) +/- 0.02(syst), for q(2) = 0.67 (GeV/c(2))(2). We compare the angular distributions of the lambda(+)(c) and lambda(-)(c) and find no evidence for CP violation: A(lambda(c)) = (alpha(lambda(c)) + alpha (lambda(c)))/(alpha(lambda(c))-alpha(lambda(c))) = 0.00 +/- 0.03(stat) +/- 0.01(syst) +/- 0.02, where the third error is from the uncertainty in the world average of the CP-violating parameter, A(lambda), for ppi(-). 相似文献
10.
Jody Lynn?Fast Serge?Ochanineochanine@ms.uky.edu" title="jfast@iglou.com ochanine@ms.uky.edu" itemprop="email" data-track="click" data-track-action="Email author" data-track-label="">Email author 《manuscripta mathematica》2004,115(1):73-83
We compute the KO-characteristic numbers of a characteristic submanifold of a Spinc manifold in terms of its K-characteristic numbers. The proof is based on the geometry of the Thom class in K-theory and is simpler than the existing proofs of several previously known special cases. 相似文献