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Min Zhou Yuxin Qian Jiayang Xie Wenjing Zhang Weinan Jiang Ximian Xiao Sheng Chen Chengzhi Dai Zihao Cong Zhemin Ji Ning Shao Longqiang Liu Yuequn Wu Runhui Liu 《Angewandte Chemie (International ed. in English)》2020,59(16):6412-6419
Peptides have important biological functions. However, their susceptibility to proteolysis limits their applications. We demonstrated here for the first time, that poly(2‐oxazoline) (POX) can work as a functional mimic of peptides. POX‐based glycine pseudopeptides, a host defense peptide mimic, had potent activities against methicillin‐resistant S. aureus, which causes formidable infections. The POX mimic showed potent activity against persisters that are highly resistant to antibiotics. S. aureus did not develop resistance to POX owning to the reactive oxygen species related antimicrobial mechanism. POX‐treated S. aureus is sensitive to common antibiotics, demonstrating no observable antimicrobial pressure or cross‐resistance in using antimicrobial POX. This study highlights POX as a new type of functional mimic of peptides and opens new avenues in designing and exploring peptide mimetics for biological functions and applications. 相似文献
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The effects of laser energy and different shock spaces and shock times on the TA2 titanium sheet deformation are investigated experimentally and simulated numerically by ABAQUS software. The results indicate that the amount of TA2 sheet deformation increases with the increase of laser energy, varies with shock order and shock path, and is the greatest when the shocks are along the length of sheet and symmetrical.The numerically simulative results are consistent with the experimental data. 相似文献
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Two new complexes: [Cu(TBZ)(bipy)Cl]Cl·H2O ( 1 ) and [Cu(TBZ)(phen)Cl]Cl·H2O ( 2 ) [TBZ=2‐(4′‐thiazolyl)‐ benzimidazole, phen=1,10‐phenanthroline and bipy=2,2′‐bipyridine] have been synthesized and characterized by elemental analysis, molar conductivity, IR, and UV‐vis methods. Complex 2 , structurally characterized by single‐crystal X‐ray crystallography, crystallizes in the monoclinic space group P21/c in a unit cell of a=0.85257(12) nm, b=2.5358(4) nm, c=1.15151(13) nm, β=118.721(8)°, V=2.183.2(5) nm3, Z=4, Dc=1.624 g·cm−3, µ=1.367 mm−1. The complexes, free ligands and chloride copper(II) salt were each tested for their ability to inhibit the growth of two gram‐positive (B. subtilis and S. aureus) and two gram‐negative (Salmonella and E. coli) bacteria. The complexes showed good antibacterial activities against the microorganisms. The interaction between the complexes and calf thymus DNA in aqueous solution was investigated adopting electronic absorption spectroscopy, fluorescence spectroscopy, viscosity measurements and cyclic voltammetry. Results suggest that the two complexes can bind to DNA by intercalative mode. In addition, the result of agarose gel electrophoresis suggested that the complexes can cleave the plasmid DNA at physiological pH and room temperature. Mechanistic studies with different inhibiting reagents reveal that hydroxyl radicals, and a singlet oxygen‐like copper‐oxo species are all involved in the DNA scission process mediated by the complexes. 相似文献
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Non-enzymatic biosensors based on various nanomaterials with large surface-volume ratios and high catalytic efficiencies have been proposed to compensate for the non-stability and high cost of enzymatic biosensors. However, the construction of a stable, highly sensitive, flexible, three-dimensional (3D), microstructured, non-enzymatic biosensor integrated with a smartphone-based portable system has been challenging. Herein, highly conductive laser-induced graphene (LIG) array with a honeycomb-like 3D microstructure co-decorated with copper(I) oxide and gold nanocatalysts was developed via simple and green electro-deposition and chemical reduction approaches for a miniaturized electrochemical flexible non-enzymatic biosensor. SEM, XRD, Raman and XPS analyzations indicated that the Cu2O and Au nanocatalysts co-decorated three-dimensional, laser-induced graphene hybrid nanomaterials were developed successfully. The signal of the biosensor was improved by more than 10 fold compared to the LIG alone due to the co-decorated with copper(I) oxide and gold nanocatalysts. The fabricated electrochemical biochip was integrated with a smartphone-based microstation for glucose monitoring, presenting a larger linear interval of 1–20 mM with an excellent sensitivity of 236 μA/mM/cm2 and a relatively low detection limit of 0.31 μM. Noticeably, the biochip could measure blood sugar on curved surfaces and still deliver stable sensing signals after being bent back-and-forth 25 times. The novel biosensor is a potentially valuable flexible electronic device. The hybrid nanomaterials developed in this work may be applicable to other biosensing, catalytic, and energy devices (supercapacitors and batteries). 相似文献
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关联性诊断作为一种重要的故障诊断方法,对于缩短民机等复杂系统故障判定时间、减少故障损失、提高检修准确性、节约维修费用等,有着重大的理论意义和应用价值。本文介绍了民用飞机故障诊断技术的研究现状,在此基础上,提出并深入阐述了一种关联性诊断方法的原理与功能设计,并以风挡防冰系统为例进行验证。结果表明,根据原理分析所建立的系统模型,能够正确识别风挡防冰子系统故障,证明了该方法的有效性。 相似文献
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Li X Li J Gao Y Kuang Y Shi J Xu B 《Journal of the American Chemical Society》2010,132(50):17707-17709
Conjugation of tripeptide derivatives with olsalazine, a clinically used anti-inflammatory prodrug, yields small molecules that self-assemble in water to form supramolecular hydrogels that undergo a gel-to-sol phase transition upon reduction, resulting in the controlled release of 5-aminosalicylic acid as the anti-inflammatory agent. This methodology will ultimately lead to new biomaterials for site-specific drug delivery. 相似文献