混合位级正交试验设计的极差分析方法

本文指出，在混合位级的正交试验设计中，以往的极差分析方法存在着不足。本文给出了极差的修正方法，并用大量实例做了数值验证，说明这个修正确实很有效     

催化裂化USY／ZnO／Al2O3脱硫添加剂的高温水热失活

 对USY／ZnO／Al2O3汽油催化裂化脱硫添加剂经高温水热老化处理前后的脱硫性能进行了考察，发现老化后添加剂的脱硫性能大幅度下降．采用XRD和IR等技术对USY／ZnO／Al2O3添加剂在高温和高温水热条件下失活的原因进行了研究．结果表明，在高温下，ZnO可与USY沸石中的铝发生固相反应生成ZnAl2O4尖晶石，从而造成USY晶体结构崩塌，转变成无定形状态．在ZnO含量较高的条件下，ZnO可继续与USY晶体结构崩塌后生成的无定形的硅和铝的氧化物反应，生成Zn2SiO4硅锌矿和ZnAl2O4尖晶石结构．这一方面使添加剂失去了可形成硫化物吸附中心的ZnO，另一方面破坏了硫化物的裂化活性组分USY，从而造成添加剂脱硫性能下降甚至失去脱硫活性．ZnO对USY的破坏作用主要与温度有关．在USY／ZnO／Al2O3体系中，ZnO被ZnO与Al2O3之间形成的锌铝尖晶石膜固定并与USY隔离，单纯的高温条件对添加剂的破坏不显著，而水蒸气可以促进ZnO的移动，有利于ZnO与USY的接触，因此在高温和有水蒸气存 在的条件下添加剂的结构易遭到破坏．     

HPLC–MS Analysis of Isoniazid in Dog Plasma

A simple, rapid, and sensitive liquid chromatography–mass spectrometric (LC–MS) method was developed and validated for the determination of isoniazid in dog plasma. Plasma samples were deproteined with methanol and separated on a C₁₈ column interfaced with a single quadrupole mass spectrometer, using 0.1% formic acid–acetonitrile (91:9 v/v) as mobile phase. Detection was performed by positive electrospray ionization with selected ion monitoring at m/z 138 for isoniazid and 152 for entecavir maleate internal standard. Linearity was obtained over the range of 25–5,000 ng mL^?1, with a lower limit of quantification of 25 ng mL^?1. The intra- and inter-day precision was less than 2.7% in terms of relative standard deviation. Accuracy, expressed as relative error, ranged from ?2.0 to 8.0%. Plasma samples were analysed within 5 min. The method was successfully applied to the evaluation of the pharmacokinetics of isoniazid in dog plasma.     

催化裂化汽油脱硫添加剂USY/ZnO/Al2O3的性能评价

 在固定流化床催化裂化装置上，以减压蜡油为原料，对制备的U\r\nSY／ZnO／Al2O3催化裂化汽油脱硫添加剂的性能进行了评价．结果表明\r\n，随着添加剂添加量和剂油比的增加，生成汽油的硫含量降低．在500\r\n℃和剂油比为5的条件下，在FCC平衡催化剂中添加30％的添加剂时，汽\r\n油的硫含量可由不加添加剂时的1230μg／g降低到770μg／g左右．添\r\n加剂的添加量（10％）较低时，对催化裂化产物的分布基本没有影响；\r\n添加30％的添加剂时，焦炭的产率有所增加，但汽油收率基本不变．X\r\nRD表征结果表明，USY／ZnO／Al2O3添加剂中的ZnO对USY的晶相结构有\r\n一定的破坏作用，但随着反应与再生次数的增多，ZnO与Al2O3之间形成\r\n较为稳定的锌铝尖晶石结构，使添加剂的性能趋于稳定．     

Two types of intramolecular addition of an Al-N multiple-bonded monomer LAlNAr' arising from the reaction of LAl with N3Ar' (L = HC[(CMe)(NAr)]2, Ar' = 2,6-Ar2C6H3, Ar = 2,6-iPr2C6H3)

The reaction of beta-diketiminated aluminum(I) monomer LAl with a large bulky azide N3Ar' (L = HC(CMeNAr)2, Ar' = 2,6-Ar2C6H3, Ar = 2,6-iPr2C6H3) in the temperature range from -78 degrees C to room temperature affords two different isomers 2 and 3, which have been characterized by spectroscopic and X-ray structural analyses, as well as elemental analysis. The variable-temperature 1H NMR kinetic studies of this reaction indicate the existence of the monomer LAlNAr' (1) at low temperature and the thermal stability of the compounds increases in the order of 1 < 2 < 3.     

On bandwidth sums of graphs

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Superresolution imaging of DNA tetrahedral nanostructures in cells by STED method with continuous wave lasers

DNA tetrahedral nanostructures are considered to be uew nanocarriers because they can be precisely controlled and hold excellent penetration ability to the cellular membrane. Although the DNA tetrahedral nanostructure is extensively studied in biology and medicine, its behavior in the cells with nanoscale resolution is not understood clearly. In this letter, we demonstrate superrcsolution fluorescence imaging of the distribution of DNA tetrahedral nanostructures in the cell with a simulated emission depletion （STED） microscope, which is built based on a conventional eonfocal microscope and can t）rovide a resolution of 70 nm.     

An oxovanadium(IV) complex with o-vanillin-valine Schiff base and 1,10-phenanthroline ligands: synthesis,crystal structure and DNA interactions

A new mixed-ligand V(IV) complex, [VO(o-Van-Val)(phen)]·CH₃CN (o-Van-val = Schiff base derived from o-vanillin and l-valine, phen = 1,10-phenanthroline), was synthesized and characterized by physico-chemical methods and single-crystal X-ray diffraction. In the crystal, the V(IV) atom is six-coordinated by one oxo ligand, two oxygen atoms and one nitrogen atom from a valine Schiff base ligand, and two nitrogen atoms from 1,10-phenanthroline, giving a distorted octahedral arrangement. The DNA-binding properties of the complex were investigated by spectroscopic methods and viscosity measurements. The results suggest that the oxovanadium(IV) complex binds to DNA in an intercalation mode.     

松香基功能高分子吸附分离盐酸小檗碱研究

探索了聚马来松香己二醇酯(PMHE 树脂)和马来松香乙二醇丙烯酯-丙烯酸共聚物poly(MGAE-AA)对盐酸小檗碱的分离提纯.实验结果表明,马来松香乙二醇丙烯酯-丙烯酸共聚物吸附分离盐酸小檗碱的效果较好,最佳条件是T=80℃,pH=6.00,振荡频率为150r/min;静态吸附量为62.47mg/g,动态吸附量为3.54mg/g.使用马来松香乙二醇丙烯酯-丙烯酸共聚物吸附盐酸小檗碱,初产品中盐酸小檗碱固含量由37.53%上升到68.91%;聚马来松香己二醇酯对盐酸小檗碱的静态吸附量为8.59mg/g,动态吸附量为0.68mg/g.     

盐诱导金纳米粒子自组装和沉降制备具有宽波段吸收特性的黑金

通过向金溶胶中加入无机盐诱导金纳米粒子自组装,并自然沉降金纳米粒子组装体得到黑金薄膜.研究结果表明,该黑金薄膜在400~1600 nm的宽带范围内表现出很强的吸收能力（>80%）,在400~800 nm的可见范围内能达到94%,表现出高光热转换能力和宽波段的高表面增强拉曼散射（SERS）活性.