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Alla Zablotskaya Izolda Segal Mikhail Maiorov Dmitry Zablotsky Anatoly Mishnev Edmunds Lukevics Irina Shestakova Ilona Domracheva 《Journal of magnetism and magnetic materials》2007
Water-soluble double-coated magnetic nanoparticles (NPs) containing cytotoxic decyldimethyl(β-dimethylaminoethoxy)silane methiodide (AA) molecule sorbed at biocompatible magnetic particles, which consist of magnetite pre-coated with oleic acid (OA), have been prepared. X-ray line profile broadening analysis was used for crystallite size determination. The method of magnetogranulometry has been used for determination of diameter of iron oxide magnetic core and magnetic properties of NPs prepared. In vitro cytotoxicity on monolayer tumor cell lines HT-1080 (human fibrosarcoma), MG-22A (mouse hepatoma) and normal mouse fibroblasts (NIH 3T3) has been studied. It was revealed that all the water-based colloidal solutions obtained are non-toxic and possess high NO-induction ability. 相似文献
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D. Kamińska A. Gajos E. Czerwiński D. Alfs T. Bednarski P. Białas C. Curceanu K. Dulski B. Głowacz N. Gupta-Sharma M. Gorgol B. C. Hiesmayr B. Jasińska G. Korcyl P. Kowalski W. Krzemień N. Krawczyk E. Kubicz M. Mohammed Sz. Niedźwiecki M. Pawlik-Niedźwiecka L. Raczyński Z. Rudy M. Silarski A. Wieczorek W. Wiślicki B. Zgardzińska M. Zieliński P. Moskal 《The European Physical Journal C - Particles and Fields》2016,76(8):445
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Alla Zablotskaya Izolda Segal Yuris Popelis Edmunds Lukevics Shipra Baluja Irina Shestakova Ilona Domracheva 《应用有机金属化学》2006,20(11):721-728
A series of triorganylsilyl(β‐dialkylaminoethoxy)silanes was prepared and characterized by elemental analysis, 1H, 13C, 29Si NMR and mass spectroscopy. Comparative study of 29Si resonance of newly synthesized compounds showed correlation between its value and substituent nature at the silicon atom, and is shifted upfield for β‐triorganyl(N,N‐dialkylaminoethoxy)silanes in comparison with corresponding methiodides, revealing weak N…Si interaction for proper silanes. In vitro antitumour and antimicrobial properties were investigated. The biological activity data exhibited a marked enhancement of inhibitory activity on trialkylsilylation against tumour cell lines and all the test bacterial/fungal strains. Copyright © 2006 John Wiley & Sons, Ltd. 相似文献
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Alla Zablotskaya Izolda Segal Mikhail Maiorov Elmars Blums Ilona Domracheva 《Journal of magnetism and magnetic materials》2009,321(10):1428-1432
We present the results of the interaction of iron oxide nanoparticles with some biologically active surfactants, namely, oleic acid and cytotoxic alkanolamine derivatives. Physico-chemical properties, as magnetization, magnetite concentration and particle diameter, of the prepared magnetic samples were studied. The nanoparticle size of 11 nm for toluene magnetic fluid determined by TEM is in good agreement with the data obtained by the method of magnetogranulometry. In vitro cytotoxic effect of water-soluble nanoparticles with different iron oxide:oleic acid molar ratio were revealed against human fibrosarcoma and mouse hepatoma cells. In vivo results using a sarcoma mouse model showed observable antitumor action. 相似文献
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6.
Pronab K. Das Izolda Ruzmaikina Laurence A. Belfiore 《Journal of Polymer Science.Polymer Physics》2000,38(14):1931-1938
Six f‐block salts from the lanthanide series form complexes with poly(vinyl amine) and increase the glass‐transition temperature of the polymer. Results for poly(vinylamine) complexes with EuCl3(H2O)6 and TbCl3(H2O)6 surpass those for d7 cobalt complexes that were studied previously. The glass‐transition temperature increases by 49 °C per mol % Eu3+ and 50 °C per mol % Tb3+, up to 2 mol % of the f‐block cations. At 5 mol % Eu3+, Tg is slightly higher than 250 °C with no visual evidence of thermal degradation of either component in the complex. This corresponds to a Tg enhancement of almost 200 °C with respect to the undiluted polymer. The increases in Tg for these lanthanide complexes with poly(vinylamine) obey the following trend: up to 2 mol % of the f‐block cation. With the exception of Gd(CH3COO)3, which contains different anionic ligands than all of the other trichlorides, this trend correlates inversely with the highest dehydration/dehydrochlorination temperature of each undiluted lanthanide salt, as measured via calorimetry above the melting point and verified by thermogravimetry. Waters of hydration and amino sidegroups undergo ligand substitution in the coordination sphere of the lanthanides. Since lanthanide cations are classified as hard acids, it is not unreasonable that they form complexes with the nitrogen lone pair in the amino sidegroup of the polymer, which is classified as a hard base. Micro‐clustering of several amino side groups reduces chain mobility significantly in the vicinity of each metal center, produces coordination crosslinks, and increases Tg. Complementary solution studies reveal that hydrogels form with swelling ratios between 20 and 50 at Eu3+ mole fractions between 0.01 and 0.05 with respect to poly(vinylamine). Infrared spectroscopic observations suggest that the amino nitrogen lone pair in poly(vinylamine) interacts with these lanthanide metal centers. © 2000 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 38: 1931–1938, 2000 相似文献
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Alla Zablotskaya Izolda Segal Anatoly Mishnev Mikhail Maiorov Elmars Blums Irina Shestakova Ilona Domracheva 《应用有机金属化学》2013,27(12):716-722
Superparamagnetic iron oxide/oleic acid nanoparticles bearing lipid‐like organosilicon N‐(2‐hydroxyethyl)‐1,2,3,4‐tetrahydroisoquinoline derivatives have been synthesized with the aim of their potential biomedical application. X‐ray diffraction analysis, Dynamic light‐scattering measurements, method of magnetogranulometry and some others have been employed to investigate the morphology and properties of the nanoparticles synthesized. The magnetic core diameter of mixed covered nanoparticles ranged between 4.8 and 9.6 nm. The magnetization analyses showed that the particles are superparamagnetic at room temperature. In vitro cell cytotoxicity and intracellular NO generation caused by the water magnetic solution of nanoparticles possessing cytotoxic organosilicon heterocyclic choline analogue, namely N‐(2‐dimethyl‐n‐hexadecylsiloxyethyl)‐N‐methyl‐1,2,3,4‐tetrahydroisoquinolinium iodide, was examined in relation to monolayer human fibrosarcoma (HT‐1080) and mouse hepatoma (MG‐22A) tumour cell lines and normal mouse fibroblasts (NIH 3T3). The biological studies have revealed its selective cytotoxicity in tumour cells and strong effect on MG‐22A cell morphology. Incorporation of the synthesized nanoparticles into cells was observed. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
8.
Alla Zablotskaya Izolda Segal Edmunds Lukevics Sergey Belyakov Hartmut Spies 《应用有机金属化学》2007,21(4):288-293
New oxorhenium complexes with 3‐methylazapentane‐1,5‐dithiolate (SNMeS) and thiol functionalized monodentate tetrahydroquinolyl and tetrahydroisoquinolyl derivatives have been synthesized by simultaneous reaction of [PPh3]2[Re(O)Cl3] with tridentate HSNMeSH and the corresponding N‐heterocycle containing thiol. The characterization of complexes involved elemental analysis, IR, 1H and 13C NMR spectroscopy and X‐ray crystallographic analysis. The nature of the heterocycle in monodentate ligand, even situated at the distance of two methylene group length, has been found to have a significant influence on the molecular conformation. Metal complexes were found to be active in psychotropic in vivo and cytotoxicity in vitro screening. Copyright © 2007 John Wiley & Sons, Ltd. 相似文献
9.
Iron oxide superparamagnetic nanocarriers bearing amphiphilic N‐heterocyclic choline analogues as potential antimicrobial agents
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Alla Zablotskaya Izolda Segal Yuris Popelis Anatoly Mishnev Mikhail Maiorov Dmitry Zablotsky Elmars Blums Vizma Nikolajeva Daina Eze 《应用有机金属化学》2015,29(6):376-383
Magnetic nanoparticles represent an advanced tool in biomedicine because they can be simultaneously functionalized and guided using a magnetic field. Iron oxide magnetic nanoparticles precoated with oleic acid and bearing novel antimicrobial N‐heterocyclic choline analogues, namely O‐, N‐ and O,N‐bis‐undecyl‐substituted N‐(2‐hydroxyethyl)‐1,2,3,4‐tetrahydroisoquinolinium derivatives, have been obtained as potential biomedical agents for drug delivery and antimicrobial therapy. Structural and size determinations for the novel synthesized magnetic nanosystems were carried out based upon magnetogranulometry, dynamic light‐scattering measurements and X‐ray diffraction analysis. The most expected iron oxide core diameter was 6.2–10.5 nm. The magnetization analyses showed that the particles are superparamagnetic at room temperature. Aqueous magnetic fluids of the synthesized nanoparticles were examined in vitro concerning Gram‐positive (Staphylococcus aureus MSCL 334, Bacillus cereus MSCL 330) and Gram‐negative (Escherichia coli MSCL 332, Pseudomonas aeruginosa MSCL 331, Proteus mirabilis MSCL 590) bacterial strains and fungi (Candida albicans MSCL 378, Aspergillus niger MSCL 324). It was found that the samples have magnetic properties and possess antimicrobial activity. The minimum inhibitory concentration against S. aureus for the most active magnetic fluid was determined as 16 µg ml?1. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
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Izolda Gorgol 《Graphs and Combinatorics》2011,27(5):661-667
The Turán number
ex(n,H){ex(n,\mathcal H)} of H{\mathcal H} is the maximum number of edges of an n-vertex simple graph having no member of H{\mathcal H} as a subgraph. We show lower and upper bounds for Turán numbers for disjoint copies of graphs. 相似文献