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排序方式: 共有63条查询结果,搜索用时 31 毫秒
1.
Synthesis of some dibenzodiazepinone derivatives as potent and m2-selective antimuscarinic compounds
Victor I. Cohen Biyun Jin Miriam S. Gitler Rosanna A. La De Cruz Waclaw J. Rzeszotarski Barry R. Zeeberg Jesse Baumgold Richard C. Reba 《Journal of heterocyclic chemistry》1994,31(4):787-791
Two series of 5-[[4-[4-(dialkylamino)butyl]-l-cyclohexyl]acetyl], and 5-[(dialkylamino)acyl]-10,11-dihydro-5H- dibenzo[b,e][1,4]diazepin-11-ones were synthesized as potential m2-selective ligands 1,2. Their affinity and selectivity for the muscarinic cholinergic receptor m-AChR subtypes were determined. Replacing a nitrogen with CH in the piperidine ring of 5-[[4-[4-(dialkylamino)butyl]-l-piperidinyl]acetyl]-10,11-dihydro-5H-dibenzo-[b,e][1,4]diazepin-11-ones 3 significantly altered the affinity and selectivity to the muscarinic receptor subtypes. 相似文献
2.
Isidoro Izquierdo María T. Plaza Rafael Robles Concepcin Rodríguez 《Tetrahedron: Asymmetry》1996,7(12)
Bishydroxylation of methyl
1 with osmium tetraoxide proceeded with extremed high diastereoselectivity to give only methyl
2. Configurations of the new stereogenic centers (C-2,3) in 2 were determined by degradation of the C-5,6,7,8 fragment to the well-known methyl
7. Transformation of 2 into the required
10, was achieved by a methodology that implied, protection to 8, reduction of the ester group in 8 to a hydroxymethyl group in 9, and finally deprotection to the free
10. On the other hand, epoxidation reaction on
11 afforded only the corresponding 2,3-anhydro derivative 12 with
configuration, as could be demonstrated by degradation to (S)-1,2,4-trimetoxybutane 16, which synthesis is reported herein. 相似文献
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3.
A new synthesis for (+)-casuarine (1) and its 6,7-diepi isomer (15) in a stereocontrolled manner, is reported herein. An appropriately protected polyhydroxylated pyrrolidine, such as (2R,3R,4R,5R)-3,4-dibenzyloxy-2′-O-tert-butyldiphenylsilyl-2,5-bis(hydroxymethyl)pyrrolidine (3, protected DMDP), easily available from d-fructose, was chosen as the chiral starting material. Compounds 1 and 15 were obtained from 3, in seven steps, in a 23.2 and 20.5% overall yields, respectively. 相似文献
4.
An absolute method to obtain molecular weight averages is theoretically proved and experimentally applied to size exclusion chromatographic data. The method is based on stoichiometric relationships and uses labelled polymer molecules. 相似文献
5.
6.
Najwa Sbei Belen Batanero Fructuoso Barba Beya Haouas Mohamed Lamine Benkhoud Isidoro Barba 《Tetrahedron》2018,74(16):2068-2072
A new series of 3,4-disubstituted quinazolin-2-ones, with potential T-type calcium channel antagonist activity, and new 4-methylene-quinazolin-2-ones, promising catalysts as N-heterocyclic olefins, have been prepared in good yield by a simple reaction between 2-aminobenzophenone, or 2-aminoacetophenone, and cyanomethyl anion electrogenerated by acetonitrile reduction at a graphite electrode, followed by the addition of different organic isocyanates and subsequent heterocyclization. 相似文献
7.
8.
Isidoro Lpez Mehmed Z. Ertem Somnath Maji Jordi Benet‐Buchholz Anke Keidel Uwe Kuhlmann Peter Hildebrandt Christopher J. Cramer Victor S. Batista Antoni Llobet 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2014,126(1):209-213
The homogeneous catalysis of water oxidation by transition‐metal complexes has experienced spectacular development over the last five years. Practical energy‐conversion schemes, however, require robust catalysts with large turnover frequencies. Herein we introduce a new oxidatively rugged and powerful dinuclear water‐oxidation catalyst that is generated by self‐assembly from a mononuclear catalyst during the catalytic process. Our kinetic and DFT computational analysis shows that two interconnected catalytic cycles coexist while the mononuclear system is slowly and irreversibly converted into the more stable dinuclear system: an extremely robust water‐oxidation catalyst that does not decompose over extended periods of time. 相似文献
9.
10.
Measuring efficiency and productivity in professional football teams: evidence from the English Premier League 总被引:1,自引:0,他引:1
Professional football clubs are unusual businesses, their performance judged on and off the field of play. This study is concerned
with measuring the efficiency of clubs in the English Premier League. Information from clubs’ financial statements is used
as a measure of corporate performance. To measure changes in efficiency and productivity the Malmquist non-parametric technique
has been used. This is derived from the Data Envelopment Analysis (DEA) linear programming approach, with Canonical Correlation
Analysis (CCA) being used to ensure the cohesion of the input–output variables. The study concludes that while clubs operate
close to efficient levels for the assessed models, there is limited technological advance in their performance in terms of
the displacement of the technological frontier.
The research was supported by the Investigation Program of the Technical University of Cartagena (Spain) and by the Department
of Sports Studies at the University of Stirling (Scotland, UK). 相似文献