On the classification of geometric codes by polynomial functions

It is shown how to represent algebraically all functions that have a zero sum on all -dimensional subspaces ofPG(n,q) or ofAG(n,q). In this way one can calculate the dimensions of related codes, or one can represent interesting sets of points by functions.     

Development of a liquid chromatography/tandem mass spectrometry assay for the quantification of PM00104, a novel antineoplastic agent, in mouse, rat, dog, and human plasma

A rapid and sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS) assay was developed and validated to quantify a novel antineoplastic agent, PM00104, in mouse, rat, dog, and human plasma. The method was validated to demonstrate the specificity, limit of quantification (LOQ), accuracy, and precision of measurements. The calibration range for PM00104 was established using PM00104 standards from 0.01-5.0 ng/mL in blank plasma. The selected reaction monitoring (SRM), based on the m/z 692.2 --> 218.2 transition, was specific for PM00104, and that based on the m/z 697.2 --> 218.2 transition was specific for PM00104 ((13)C(2),(2)H(3)) (the internal standard, IS); no endogenous materials interfered with the analysis of PM00104 and IS from blank plasma. The assay was linear over the concentration range 0.01-5.0 ng/mL. The correlation coefficients for the calibration curves ranged from 0.9981-0.9999. The mean intra-day and inter-day accuracies for all calibration standards (n = 8) ranged from 97-105% (< or =5% bias) in human plasma, and the mean inter-day precision for all calibration standards was less than 8.5%. The mean intra- and inter-day assay accuracy for all quality control (QC) replicates in human plasma (n = 9), determined at each QC level throughout the validated runs, ranged from 96-112% (< or =12% bias) and from 102-105% (< or =5% bias), respectively. The mean intra- and inter-day assay precision was less than 15.0 and 11.8% for all QC levels, respectively. For the QC samples prepared in animal species plasma, the %CV values of the assays ranged from 1.8-8.8% in mouse plasma, from 3.7-13.8% in rat plasma, and from 3.0-7.2% in dog plasma. The assay accuracies ranged from 92-102% (< or =8% bias) for all QC levels prepared in mouse plasma; ranged from 93-106% (< or =7% bias) in rat plasma; and ranged from 95-114% (< or =14% bias) in dog plasma. The assay has been used to support preclinical pharmacokinetic and toxicokinetic studies and is currently used to measure PM00104 plasma concentrations to support clinical trials.     

Kinetics of Alkaline Hydrolysis of Quaternary Phosphonium Salts. The Influence of Protic and Aprotic Solvents on the Hydrolysis of Alkyl Phenylphosphonium Salts

Abstract

Third order rate constants have been determined for the alkaline hydrolysis of four series of alkylphenylphosphonium salts and alkylphenylbenzylphosphonium salts at various temperatures in 50%–70% ^v/_v aqueous tetrahydrofuran and 70% ^v/_v aqueous methanol. Thermodynamic activation parameters have been calculated for the reactions of each substrate and the effects of varying the ratio of alkyl to phenyl groups have been compared, as well as the effects of changes in the nature of the alkyl group. Solvation, as revealed by trends in entropy of activation, plays a largely counter-balancing role with respect to enthalpy and energy of activation. The role of the isokinetic effect is discussed. In aqueous tetrahydrofuran, solvation effects on the hydrolyses of phosphonium salts change as the mole fraction of water changes, and for aqueous methanol the trends in the thermodynamic activation parameters actually reverse.     

Additive manufacturing for energy storage: Methods,designs and material selection for customizable 3D printed batteries and supercapacitors

Additive manufacturing and 3D printing in particular have the potential to revolutionize existing fabrication processes, where objects with complex structures and shapes can be built with multifunctional material systems. For electrochemical energy storage devices such as batteries and supercapacitors, 3D printing methods allows alternative form factors to be conceived based on the end use application need in mind at the design stage. Additively manufactured energy storage devices require active materials and composites that are printable, and this is influenced by performance requirements and the basic electrochemistry. The interplay between electrochemical response, stability, material type, object complexity and end use application are key to realising 3D printing for electrochemical energy storage. Here, we summarise recent advances and highlight the important role of methods, designs and material selection for energy storage devices made by 3D printing, which is general to the majority of methods in use currently.     

Untersuchung von Fleisch, Fleischextrakt und Wurstwaren

Ohne Zusammenfassung     

Suppressing shape instabilities to discover the Bjerknes force instability (L)

For sufficiently strong acoustic forcing in a standing wave field, subresonant size bubbles are predicted to be repelled from the pressure antinode. Single bubble sonoluminescence (SBSL) conditions in water do not allow the observation of this instability. This study investigates the possibility that increasing the viscosity of the host liquid can preferentially suppress shape instabilities of a bubble and allow SBSL experiments to be limited by the Bjerknes force instability.     

Limit Theory for Taboo-Regenerative Processes

The paper considers the two-sided taboo limit process that arises when a regenerative process X is conditioned on staying out of a specified set of states (taboo set) over a long period of time. The taboo limit process after time 0 is a version of X, and the time-reversal of the taboo limit process before time 0 is regenerative with tabooed cycles having exponentially biased lengths. The cycle straddling zero has that same bias up to time 0, and is unbiased after time 0. This extends to processes regenerative in the wide sense, and to processes that only regenerate as long as they have not entered the taboo set.     

Uniform approximations for the M/G/1 queue with subexponential processing times

This paper studies the asymptotic behavior of the steady-state waiting time, W _∞, of the M/G/1 queue with Subexponential processing times for different combinations of traffic intensities and overflow levels. In particular, we provide insights into the regions of large deviations where the so-called heavy-traffic approximation and heavy-tail asymptotic hold. For queues whose service time distribution decays slower than \(e^{-\sqrt{t}}\) we identify a third region of asymptotics where neither the heavy-traffic nor the heavy-tail approximations are valid. These results are obtained by deriving approximations for P(W _∞>x) that are either uniform in the traffic intensity as the tail value goes to infinity or uniform on the positive axis as the traffic intensity converges to one. Our approach makes clear the connection between the asymptotic behavior of the steady-state waiting time distribution and that of an associated random walk.     

On Conics that are Ovals in a Hall Plane

The conics of a finite Desarguesian plane of square even order satisfying the following properties are classified. (1) Their two infinite points (one being the nucleus) do not intersect a certain derivation set. (2) They are also ovals in the Hall plane constructed from the derivation set. This leads to a construction of ovals from conics in certain subregular planes of even order (which are translation planes of dimension 2 over their kernel).