排序方式: 共有27条查询结果,搜索用时 15 毫秒
1.
Gabriel GJ Pool JG Som A Dabkowski JM Coughlin EB Muthukumar M Tew GN 《Langmuir : the ACS journal of surfaces and colloids》2008,24(21):12489-12495
Antimicrobial polynorbornenes composed of facially amphiphilic monomers have been previously reported to accurately emulate the antimicrobial activity of natural host-defense peptides (HDPs). The lethal mechanism of most HDPs involves binding to the membrane surface of bacteria leading to compromised phospholipid bilayers. In this paper, the interactions between biomimetic vesicle membranes and these cationic antimicrobial polynorbornenes are reported. Vesicle dye-leakage experiments were consistent with previous biological assays and corroborated a mode of action involving membrane disruption. Dynamic light scattering (DLS) showed that these antimicrobial polymers cause extensive aggregation of vesicles without complete bilayer disintegration as observed with surfactants that efficiently solubilize the membrane. Fluorescence microscopy on vesicles and bacterial cells also showed polymer-induced aggregation of both synthetic vesicles and bacterial cells. Isothermal titration calorimetry (ITC) afforded free energy of binding values (Delta G) and polymer to lipid binding ratios, plus revealed that the interaction is entropically favorable (Delta S>0, Delta H>0). It was observed that the strength of vesicle binding was similar between the active polymers while the binding stoichiometries were dramatically different. 相似文献
2.
Wojciech Dabkowski Andrzej Łopusiński Jan Michalski Czesłw Radziejewski 《Phosphorus, sulfur, and silicon and the related elements》2013,188(3):375-377
Abstract Racemic and optically active S-sulphonylphosphinothioates R-SO2-S-P(O)Bu'Ph and dithioates R-SO2-S-P(S)Bu'Ph (R [dbnd] Me, p-tolyl) have been prepared for the first time by the reaction of the corresponding acids Bu'PhP(S)SH (X [dbnd] O,S) of their salts with sulphonylating reagents RSO2-Y (Y [dbnd] Cl, O-SO2R, triazolide). 相似文献
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Michael Dabkowski 《Geometric And Functional Analysis》2011,21(1):1-13
We show that a solution to the supercritical surface quasi-geostrophic equation that is smooth up to a certain time must remain
smooth forever. 相似文献
4.
The use of small amplitude cyclic voltammetry for investigation of the β-alumina/metallic electrode interface is proposed. Voltammetric curve analysis is based on the electric circuit consisting of three elements. The plots of the reciprocal of capacity determined from voltammograms versus the reciprocal of voltage sweep period square root are extrapolated to obtain the limiting value of capacity. This limit corresponds to CLF obtained in the ac impedance technique. This method can be mostly useful when the low frequency limit in impedance measurements is insufficient for exact determination of capacitive components of the electric equivalent circuit. 相似文献
5.
John H. Clifford Michael G. Dabkowski 《Journal of Mathematical Analysis and Applications》2005,305(1):183-196
We find the singular values and corresponding Schmidt pairs of a compact composition operator Cφ induced by φ(z)=az+b, where |a|+|b|<1, on the classical Hardy space. We do so by solving a functional equation that is a generalization of Schröder's equation: find a function f, holomorphic on the open unit disc, and a complex number λ such that G(z)f(ψ(z))=λf(ψ(z)), where ψ is a holomorphic self-map of the open unit disc with an interior fixed point and G is a bounded holomorphic function on the open unit disc. In addition, we find the spectrum of the weighted composition operator MGCψ. 相似文献
6.
For a Kähler metric, the Riemannian scalar curvature is equal to twice the Chern scalar curvature. The question we address here is whether this equivalence can hold for a non-Kähler Hermitian metric. For such metrics, if they exist, the Chern scalar curvature would have the same geometric meaning as the Riemannian scalar curvature. Recently, Liu–Yang showed that if this equivalence of scalar curvatures holds even in average over a compact Hermitian manifold, then the metric must in fact be Kähler. However, we prove that a certain class of non-compact complex manifolds do admit Hermitian metrics for which this equivalence holds. Subsequently, the question of to what extent the behavior of said metrics can be dictated is addressed and a classification theorem is proved. 相似文献
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This paper is concerned with the study of a diffusive perturbation of the linear LSW model introduced by Carr and Penrose. A main subject of interest is to understand how the presence of diffusion acts as a selection principle, which singles out a particular self-similar solution of the linear LSW model as determining the large time behavior of the diffusive model. A selection principle is rigorously proven for a model which is a semiclassical approximation to the diffusive model. Upper bounds on the rate of coarsening are also obtained for the full diffusive model. 相似文献
9.
We present a very efficient synthetic procedure leading to the phosphorofluoridates RO-P(O)(OH)F 1 or phosphorofluoridothioates RO-P(S)(OH)F 2, which is based on the intermediary of fluorophosphoramidites (RO)P(F)N(i)Pr2 5 [R = 9-(hydroxyethyloxymethyl)guaninyl), 3'azido-3'deoxythymidinyl, thymidinyl, anhydrothymidinyl, cholesteryl, N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosinyl]. The activation of the amino group was performed with trimethylchlorosilane (TMCS). 相似文献
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