Natural Compounds and Products from an Anti-Aging Perspective

Aging is a very complex process that is accompanied by a degenerative impairment in many of the major functions of the human body over time. This inevitable process is influenced by hereditary factors, lifestyle, and environmental influences such as xenobiotic pollution, infectious agents, UV radiation, diet-borne toxins, and so on. Many external and internal signs and symptoms are related with the aging process and senescence, including skin dryness and wrinkles, atherosclerosis, diabetes, neurodegenerative disorders, cancer, etc. Oxidative stress, a consequence of the imbalance between pro- and antioxidants, is one of the main provoking factors causing aging-related damages and concerns, due to the generation of highly reactive byproducts such as reactive oxygen and nitrogen species during the metabolism, which result in cellular damage and apoptosis. Antioxidants can prevent these processes and extend healthy longevity due to the ability to inhibit the formation of free radicals or interrupt their propagation, thereby lowering the level of oxidative stress. This review focuses on supporting the antioxidant system of the organism by balancing the diet through the consumption of the necessary amount of natural ingredients, including vitamins, minerals, polyunsaturated fatty acids (PUFA), essential amino acids, probiotics, plants’ fibers, nutritional supplements, polyphenols, some phytoextracts, and drinking water.     

On a proximal point method for convex optimization in banach spaces

We analyze the behavior of a parallel proximal point method for solving convex optimization problems in reflexive Banach spaces. Similar algorithms were known to converge under the implicit assumption that the norm of the space is Hilbertian. We extend the area of applicability of the proximal point method to solving convex optimization problems in Banach spaces on which totally convex functions can be found. This includes the class of all smooth uniformly convex Banach spaces. Also, our convergence results leave more flexibility for the choice of the penalty function involved in the algorithm and, in this way, allow simplification of the computational procedure.     

Covalent anionic copolymer coatings with tunable electroosmotic flow for optimization of capillary electrophoretic separations

We present a method for finely adjustable electroosmotic flow (EOF) velocity in cathodic direction for the optimization of separations in capillary electrophoresis. To this end, we use surface modification of the separation fused silica capillary by the covalently attached copolymer of acrylamide (AM) and 2-acrylamido-2-methyl-1-propanesulfonate (AMPS), that is, poly(AM-co-AMPS) or PAMAMPS. Coatings were formed by the in-capillary polymerization of a mixture of the neutral AM and anionic AMPS monomers premixed in various ratios in order to control the charge density of the copolymer. EOF mobility varies in the 0 to ∼40 × 10⁻⁹ m² V⁻¹ s⁻¹ interval for PAMAMPS coatings ranging from 0 to 60 mol.% of charged AMPS monomer. For EOF in PAMAMPS-treated capillaries, we observed (i) a negligible dependence on pH in the 2–10 interval, (ii) a minor variance among background electrolytes (BGEs) in function of their components and (iii) its standard decrease with increasing ionic strength of the BGE. Interest in variable cathodic EOF was demonstrated by the amelioration of separation of two kinds of isomeric anionic analytes, that is, monosaccharides phosphates and helquat enantiomers, in counter-EOF mode.     

Regularization of Monotone Variational Inequalities with Mosco Approximations of the Constraint Sets

In this paper we study the convergence and stability in reflexive, smooth and strictly convex Banach spaces of a regularization method for variational inequalities with data perturbations. We prove that, when applied to perturbed variational inequalities with monotone, demiclosed, convex valued operators satisfying certain conditions of asymptotic growth, the regularization method we consider produces sequences which converge weakly to the minimal-norm solution of the original variational inequality, provided that the perturbed constraint sets converge to the constraint set of the original inequality in the sense of a modified form of Mosco convergence of order ≥1. If the underlying Banach space has the Kadeč–Klee property, then the sequence generated by that regularization method is strongly convergent. Mathematics Subject Classifications (2000) Primary: 47J0G, 47A52; secondary: 47H14, 47J20.     

Shapley mappings and the cumulative value for n-person games with fuzzy coalitions

In this paper we prove existence and uniqueness of the so-called Shapley mapping, which is a solution concept for a class of n-person games with fuzzy coalitions whose elements are defined by the specific structure of their characteristic functions. The Shapley mapping, when it exists, associates to each fuzzy coalition in the game an allocation of the coalitional worth satisfying the efficiency, the symmetry, and the null-player conditions. It determines a “cumulative value” that is the “sum” of all coalitional allocations for whose computation we provide an explicit formula.     

Additive fuzzy measures and integrals I

A point of view concerning “fuzzy measures” is explained. To this end, a new concept of “disjointness” for fuzzy is introduced and studied. Also, a concept of an “additive class of fuzzy sets” is defined to be a class of fuzzy sets closed under some “additive operations.” The fuzzy measures are defined to be sum-preserving real functions over such additive classes. Some basic properties of the fuzzy measures are derived. In contrast with other homonymous concepts studied in literature, our fuzzy measures lead to an additive fuzzy integral (see the part II of the paper).     

Values and cores of fuzzy games with infinitely many players

The problem of the existence ofvalues (FA-valued, linear, positive, symmetric and efficient operators) on symmetric spaces of “fuzzy games” (that is, ideal set functions of bounded variation) arises naturally from [8], [18], [23] and [2], [3], [4] where it is implicitely approached for technical purposes. In our present work, this problem is approached in itself for the main reason that it is essentially related with the problem of the existence of significant countable additive measures lying in the cores of the “market games”. In fact, it is shown here that there exists a continuous value on the closed subspacebv′ICA ofIBV spanned by thebv′ functions of “fuzzy probability measures” ([9]), this values is “diagonal” onpICA, the closed subspace ofbv′ICA spanned by the natural powers of the fuzzy measures and this is used to prove the main result stating that the cooperative markets contained inpICA have unique fuzzy measures in their cores which are exactly the corresponding diagonal values. This result is of interest because it is providing a tool of determiningCA measures lying in the cores of large classes of games which are not necessarily “non-atomic” and, specially, because it is opening a way toward a new approach of the “Value Equivalence Principle” for differentiable markets with a continuum of traders which are not “perfectly competitive”.