On some new generalized difference sequence spaces defined by a sequence of moduli

In this paper, we define the new generalized difference sequence spaces [V, λ, F, p, q]₀(Δ _v ^m ), [V, λ, F, p, q]₁(Δ _v ^m ) and [V, λ, F, p, q]_∞(Δ _v ^m ). We also study some inclusion relations between these spaces.     

Microstructure of thermoelectric (Bi0.15Sb0.85)2Te3 film

The film of thermoelectric ternary p-type (Bi_0.15Sb_0.85)₂Te₃ was deposited on polyimide foil substrate at 168 °C using direct-current magnetron sputtering. Microstructural investigations of the film were performed by electron microscopy techniques. SEM observations showed that the film surface consisted of large-sized particulates with small-sized particles and also mound-like crystal agglomerates in some areas. Chemical composition of the film was analyzed using energy-dispersive X-ray spectrometer (EDS). It has been observed that the EDS results were in an agreement with nominal composition for the film. Detailed microstructural investigations were carried out using transmission electron microscopy (TEM). TEM images and selected area electron diffraction patterns showed that the film has randomly oriented polycrystalline grain structure. High-resolution TEM images indicated that the microstructure of film also contained nano-crystal structure, smaller than 10 nm.     

Effects of OCRA parameters and learning rate on machine scheduling

Central European Journal of Operations Research - In this paper, the effects of Occupational Repetitive Actions (OCRA) parameters, learning rate on process times, and machine scheduling were...     

Synthesis,characterization and control of eight process-related and two genotoxic fingolimod impurities by a validated RP-UPLC method

An HPLC method has been described in the European Pharmacopoeia and United States Pharmacopeia for the determination of nine organic impurities (imp A–I) in fingolimod hydrochloride, a synthetic sphingosine-1-phosphate receptor modulator. The manufacturing process of fingolimod hydrochloride consists of multistep chemical synthesis wherein controls of precursors, intermediates and process steps should be performed to assure the final quality of the drug substance. We synthesized and isolated eight process-related impurities (FINI imp A–H) of fingolimod, which were different from the pharmacopoeial impurities. One unknown process-related impurity was found as a key intermediate (FINI) and was identified by LC–MS. Characterization of all of the impurities were done using spectroscopic techniques (¹H and ¹³C NMR, FTIR, MS), and the mechanistic pathways to the formation of these impurities were also discussed. Two of these impurities were evaluated as potential genotoxic impurities owing to their alerting structures and alkylating properties (alkyl sulfonates and alkyl halides, class 3, ICH M7). We also developed and validated an RP-UPLC method in line with ICH Q2 guidelines for control these impurities (FINI imp A–H) and to assure the pharmacopoeial quality drug substance.     

Existence and Comparison Results for First Order Periodic Implicit Difference Equations with Maxima

In this paper, we establish comparison results (maximum principles) which allow us to use the monotone method and the method of upper and lower solutions in order to build convergent sequences to the solutions of difference equations of the type j u k = f k , u k +1 , max l ] { k m h +1,…, k +1} u l , k ] I , u 0 = u T , with j u k = u k +1 m u k , I ={0,1,…, T m 1} and f ] C ( I 2 R 2 R , R ).     

Mixed partial elasticities in constant returns-to-scale production technologies

Recently, Podinovski and Førsund (2010) developed a linear programming approach to the analysis and calculation of a class of mixed partial elasticity measures in variable returns-to-scale (VRS) production technologies. In the current paper, we extend their approach to the constant returns-to-scale (CRS) technologies and formulate linear programs required for the computation of elasticity measures. Among other results obtained in this paper, we prove a new result, valid in both VRS and CRS technologies, that allows us to identify the reason why the corresponding elasticity measure is undefined at the unit. This removes the need for a preliminary sorting of the units into those units where the elasticity measure applies and those where it does not.     

First order difference equations with maxima and nonlinear functional boundary value conditions

This paper is devoted to the existence of solutions for a problem of first order difference equations with maxima and with nonlinear functional boundary value conditions. Such boundary conditions include, among others, initial, periodic, antiperiodic and multipoint boundary value conditions, as particular cases.     

Electrochemical Investigation of Ruxolitinib: Sensitive Voltammetric Assay in Drug Product and Human Serum by Using Different Solid Electrodes

Ruxolitinib (RUX), a compound of the pyrrolopyrimidines class with activity as a tyrosine kinase inhibitory drug, is used to treat myelofibrosis. This study is reported for the detailed electrochemical behavior of RUX. The effects of supporting electrolyte, pH, and scanning rate on the peak potentials and currents of RUX were investigated by BDDE and GCE using different voltammetric techniques. Under optimum experimental conditions, calibration curves for RUX were obtained as 4 μM–80 μM and 1 μM–80 μM with a limit of detection (LOD) of 0.517 μM and 0.192 μM by the GCE and BDDE, respectively using DPV.     

Postfunctionalization of polyoxanorbornene backbone through the combination of bromination and nitroxide radical coupling reactions

The brominated backbone of poly(oxanorbornene imide) (PONB) (PONB‐Br) was functionalized with 2,2,6,6‐tetramethylpiperidine 1‐oxyl (TEMPO)‐acrylate, ‐epoxy, and poly (ethylene glycol) (PEG) yielding PONB‐acrylate, PONB‐epoxy, and PONB‐PEG through the nitroxide radical coupling (NRC) reaction. Although an excess amount of functional‐TEMPOs were used. The observed NRC efficiencies were found in the range of 7–25%. Notably, ¹H NMR spectra of all polymers exhibited a signal at 6.08 ppm after NRC reactions indicating rebuilding of the main chain double bond and further identified by ¹³C NMR analysis. The inevitable formation of double bond through the tendency of the recombination of the formed radicals was supported by a separate experiment conducted without utilizing functional‐TEMPO. Besides, the versatility of the ROMP backbone further demonstrated by the introduction hetero functionality onto the polymer by a consecutive reactions. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015 , 53, 2381–2389