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排序方式: 共有113条查询结果,搜索用时 15 毫秒
1.
We discuss the approximation of performance measures in multi-class M/M/k queues with preemptive priorities for large problem instances (many classes and servers) using class aggregation and server reduction. We compared our approximations to exact and simulation results and found that our approach yields small-to-moderate approximation errors. 相似文献
2.
Kuo-yuan Hung Renata Kowalczyk Ami Desai Margaret A. Brimble John F. Marshall Paul W. R. Harris 《Molecules (Basel, Switzerland)》2022,27(14)
A20FMDV2 is a 20-mer peptide that exhibits high selectivity and affinity for the tumour-related αvβ6 integrin that can compete with extracellular ligands for the crucial RGD binding site, playing a role as a promising αvβ6-specific inhibitor for anti-cancer therapies. Unfortunately, the clinical value of A20FMDV2 is limited by its poor half-life in blood caused by rapid renal excretion and its reported high susceptibility to serum proteases. The incorporation of poly (ethylene glycol) chains, coined PEGylation, is a well-established approach to improve the pharmacokinetic properties of drug molecules. Here, we report a systematic study on the incorporation of a varying number of ethylene glycol units (1–20) into the A20FMDV2 peptide to establish the effects of PEGylation size on the peptide stability in both rat serum and human plasma. In addition, the effect of acetyl and propionyl PEGylation handles on peptide stability is also described. Selected peptide analogues were assessed for integrin-αvβ6-targeted binding, showing good specificity and activity in vitro. Stability studies in rat serum established that all of the PEGylated peptides displayed good stability, and an A20FMDV2 peptide containing twenty ethylene glycol units (PEG20) was the most stable. Surprisingly, the stability testing in human plasma identified shorter PEGs (PEG2 and PEG5) as more resistant to degradation than longer PEGs, a trend which was also observed with affinity binding to integrin αvβ6. 相似文献
3.
Aldoximes are readily dehydrated to nitriles with Raney nickel in refluxing 2-propanol. 相似文献
4.
A mechanistic study was carried out for the asymmetric Michael addition reaction of malonates to enones catalyzed by a primary amino acid lithium salt to elucidate the origin of the asymmetric induction. A primary β-amino acid salt catalyst, O-TBDPS β-homoserine lithium salt, exhibited much higher enantioselectivity than that achieved with the corresponding catalysts derived from α- and γ-amino acids for this reaction. Detailed studies of the transition states with DFT calculations revealed that the lithium cation and carboxylate group of the β-amino acid salt catalyst have important roles in achieving high enantioselectivity in the Michael addition reaction of malonates to enones. 相似文献
5.
A new high: Cannabis as a budding source of carbon-based materials for electrochemical power sources
Zahra I. Rana Ami R. Shah Alice V. Llewellyn Katrina Mazloomian Patricia McAlernon Thomas S. Miller Patrick L. Cullen Paul R. Shearing Dan J.L. Brett 《Current Opinion in Electrochemistry》2022
Cannabis sativa L., a low-cost, fast-growing herbaceous plant, is seeing a resurgence in widespread cultivation as a result of new policies and product drive. Its biodegradable and environmentally benign nature coupled with its high specific surface area and three-dimensional hierarchal structure makes it an excellent candidate for use as a biomass-derived carbon material for electrochemical power sources. It is proposed that this ‘wonder crop’ could have an important role in the energy transition by providing high-functioning carbon-based materials for electrochemistry. In this article, all instances of C. sativa usage in batteries, fuel cells and supercapacitors are discussed with a focus on highlighting the high capacity, rate capability, capacitance, current density and half-wave potential that can be achieved with its utilisation in the field. 相似文献
6.
Ami Viselter 《Journal of Functional Analysis》2009,256(2):594-602
We provide a necessary and sufficient condition for the representability of a function as the classical multidimensional Laplace transform, when the support of the representing measure is contained in some generalized semi-algebraic set. This is done by employing a method of Putinar and Vasilescu [M. Putinar, F.-H. Vasilescu, Solving moment problems by dimensional extension, Ann. of Math. (2) 149 (3) (1999) 1087-1107] for the corresponding multidimensional moment problem. 相似文献
7.
Ana Amić Zoran Marković Jasmina M. Dimitrić Marković Dejan Milenković Bono Lučić 《Molecular physics》2013,111(2):207-217
ABSTRACTParticipation of guaiacyl moiety of 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA) in inactivation of free radicals was investigated using the DFT method. The thermodynamics of triple (3H+/3e?) free radical scavenging mechanisms was investigated. The Gibbs free energies of reactions of inactivation of selected 10 free radicals indicate DHMBA as a potent scavenger. Obtained results allow us to suggest that the contribution of guaiacyl moiety to antioxidant activity of phenolic compounds should be taken into account, what has been scarcely considered until now. 相似文献
8.
Order Acceptance (OA) is one of the main functions in business control. Accepting an order when capacity is available could
disable the system to accept more profitable orders in the future with opportunity losses as a consequence. Uncertain information
is also an important issue here. We use Markov decision models and learning methods from Artificial Intelligence to find decision
policies under uncertainty. Reinforcement Learning (RL) is quite a new approach in OA. It is shown here that RL works well
compared with heuristics. It is demonstrated that employing an RL trained agent is a robust, flexible approach that in addition
can be used to support the detection of good heuristics. 相似文献
9.
Using mean field theory and high temperature expansions the transition temperature, entropy jump and heat capacity are calculated in the recent microscopic model of defect melting proposed by Kleinert. The results are compared with the experimental data for almost isotropic substances. 相似文献
10.
Ami Mamolo Tristram Bogart 《International Journal of Mathematical Education in Science & Technology》2013,44(5):615-623
This article presents a novel re-conceptualisation to a well-known problem – The Ping-Pong Ball Conundrum. We introduce a variant of this super-task by considering it through the lens of ‘measuring infinity’ – a conceptualisation of infinity that extrapolates measuring properties of numbers, rather than cardinal properties. This approach is consistent with a nonstandard analysis approach to infinite numbers, and gives credence to the intuitive (but otherwise normatively incorrect) resolution. We explore the mathematical motivation and consequences of this variant, as well as offer further ‘riffs’ on the infinite ball problem for consideration. 相似文献