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Fahd M. Abdelkarem Alaa M. Nafady Ahmed E. Allam Mahmoud A. H. Mostafa Rwaida A. Al Haidari Heba Ali Hassan Magdi E. A. Zaki Hamdy K. Assaf Mohamed R. Kamel Sabry A. H. Zidan Ahmed M. Sayed Kuniyoshi Shimizu 《Molecules (Basel, Switzerland)》2022,27(21)
Chemical investigation of the total extract of the Egyptian soft coral Heteroxenia fuscescens, led to the isolation of eight compounds, including two new metabolites, sesquiterpene fusceterpene A (1) and a sterol fuscesterol A (4), along with six known compounds. The structures of 1–8 were elucidated via intensive studies of their 1D, 2D-NMR, and HR-MS analyses, as well as a comparison of their spectral data with those mentioned in the literature. Subsequent comprehensive in-silico-based investigations against almost all viral proteins, including those of the new variants, e.g., Omicron, revealed the most probable target for these isolated compounds, which was found to be Mpro. Additionally, the dynamic modes of interaction of the putatively active compounds were highlighted, depending on 50-ns-long MDS. In conclusion, the structural information provided in the current investigation highlights the antiviral potential of H. fuscescens metabolites with 3β,5α,6β-trihydroxy steroids with different nuclei against SARS-CoV-2, including newly widespread variants. 相似文献
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M'Hamed Berkaoui Francis Outurquin Claude Paulmier 《Journal of heterocyclic chemistry》1996,33(1):9-16
The acid catalyzed reaction of 3-thiophenamines with aldehydes in the presence of selenophenol as the reducing agent, gives 2-alkyl-3-miophenamines. Without reduction, bis(3-amino-2-thienyl)methane derivatives have been obtained and transformed into dithieno[3,2-b:2′,3′-e]pyridines by thermal and acidic treatment when the substrates are primary amines. These new tricyclic heterocycles can be synthesized in a one-pot procedure from 3-thiophenamine. 相似文献
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Thin films of Cu2O/CuO mixed phase have been deposited on pre-cleaned glass substrate by a spin-coating technique. The influence of Cr-doping, (Cr?+?S) co-doping and the number of coated layers on the structures and optical behaviors of the films were investigated by X-ray diffraction (XRD), Fourier transform infrared (FTIR), Raman, and UV-Visible spectroscopies. From XRD, FTIR and Raman results; the films are composed of polycrystalline monoclinic CuO and cubic Cu2O phases with crystallite sizes ranged from 10.05 to 23.08?nm. Increasing the thickness improves the films’ crystallinity and decreases the defects level in the films. Cr and S incorporation encourages the growth of CuO phase at the expense of Cu2O one and affects the preferred growth direction. The doping with Cr and S blue shifted the Bg mode and multi-phonon transitions. The direct and indirect optical band gaps decreased from 2.25?eV and 1.60?eV to 2.10?eV and 1.20?eV by growing the number of deposited layers from 2 to 8 layers. The film sensitivity towards CO2 at different gas flow rate was studied and compared with those of similar systems. Also; response time, recovery time, detection limit, and limit of quantification are estimated. 相似文献
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