全文获取类型
收费全文 | 21115篇 |
免费 | 1088篇 |
国内免费 | 1440篇 |
专业分类
化学 | 16139篇 |
晶体学 | 178篇 |
力学 | 412篇 |
综合类 | 10篇 |
数学 | 3022篇 |
物理学 | 3882篇 |
出版年
2023年 | 152篇 |
2022年 | 398篇 |
2021年 | 482篇 |
2020年 | 374篇 |
2019年 | 398篇 |
2018年 | 382篇 |
2017年 | 358篇 |
2016年 | 776篇 |
2015年 | 654篇 |
2014年 | 725篇 |
2013年 | 1552篇 |
2012年 | 1650篇 |
2011年 | 1755篇 |
2010年 | 1005篇 |
2009年 | 1224篇 |
2008年 | 1280篇 |
2007年 | 1220篇 |
2006年 | 1077篇 |
2005年 | 1085篇 |
2004年 | 1324篇 |
2003年 | 954篇 |
2002年 | 882篇 |
2001年 | 445篇 |
2000年 | 370篇 |
1999年 | 278篇 |
1998年 | 256篇 |
1997年 | 222篇 |
1996年 | 251篇 |
1995年 | 191篇 |
1994年 | 159篇 |
1993年 | 167篇 |
1992年 | 151篇 |
1991年 | 104篇 |
1990年 | 107篇 |
1989年 | 84篇 |
1988年 | 79篇 |
1987年 | 70篇 |
1986年 | 81篇 |
1985年 | 111篇 |
1984年 | 102篇 |
1983年 | 76篇 |
1982年 | 72篇 |
1981年 | 75篇 |
1980年 | 63篇 |
1979年 | 43篇 |
1978年 | 35篇 |
1977年 | 41篇 |
1976年 | 30篇 |
1975年 | 31篇 |
1974年 | 32篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
Peralta Cecilia Mariana Acosta Gimena Henestrosa Cecilia Gil Raúl Andrés Fernández Liliana Patricia 《Journal of Analytical Chemistry》2022,77(3):308-317
Journal of Analytical Chemistry - The present development involved a flow injection strategy using a mini-column of multiwalled carbon nanotubes and fluorescent detection (λex of 283 nm,... 相似文献
2.
Verdecho María-José Alarcón-Valero Faustino Pérez-Perales David Alfaro-Saiz Juan-José Rodríguez-Rodríguez Raúl 《Central European Journal of Operations Research》2021,29(4):1231-1251
Central European Journal of Operations Research - Sustainability practice within supply chains remains in an early development phase. Enterprises still need tools that support the integration of... 相似文献
3.
Dr. Joaquim Torra Dr. Felipe Viela Dr. Diego Megías Dr. Begoña Sot Prof. Cristina Flors 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(19):e202200026
CRANAD-2 is a fluorogenic curcumin derivative used for near-infrared detection and imaging in vivo of amyloid aggregates, which are involved in neurodegenerative diseases. We explore the performance of CRANAD-2 in two super-resolution imaging techniques, namely stimulated emission depletion (STED) and single-molecule localization microscopy (SMLM), with markedly different fluorophore requirements. By conveniently adapting the concentration of CRANAD-2, which transiently binds to amyloid fibrils, we show that it performs well in both techniques, achieving a resolution in the range of 45–55 nm. Correlation of SMLM with atomic force microscopy (AFM) validates the resolution of fine features in the reconstructed super-resolved image. The good performance and versatility of CRANAD-2 provides a powerful tool for near-infrared nanoscopic imaging of amyloids in vitro and in vivo. 相似文献
4.
5.
6.
Dr. Antonio M. Rodríguez Dr. Pilar Prieto Prof. Antonio de la Hoz Prof. Ángel Díaz-Ortiz D. Raúl Martín Prof. José I. García 《ChemistryOpen》2015,4(3):308-317
The aim of this work was to determine the parameters that have decisive roles in microwave-assisted reactions and to develop a model, using computational chemistry, to predict a priori the type of reactions that can be improved under microwaves. For this purpose, a computational study was carried out on a variety of reactions, which have been reported to be improved under microwave irradiation. This comprises six types of reactions. The outcomes obtained in this study indicate that the most influential parameters are activation energy, enthalpy, and the polarity of all the species that participate. In addition to this, in most cases, slower reacting systems observe a much greater improvement under microwave irradiation. Furthermore, for these reactions, the presence of a polar component in the reaction (solvent, reagent, susceptor, etc.) is necessary for strong coupling with the electromagnetic radiation. We also quantified that an activation energy of 20–30 kcal mol−1 and a polarity (μ) between 7–20 D of the species involved in the process is required to obtain significant improvements under microwave irradiation. 相似文献
7.
Experimental and Theoretical Studies on the Rearrangement of 2‐Oxoazepane α,α‐Amino Acids into 2′‐Oxopiperidine β2,3,3‐Amino Acids: An Example of Intramolecular Catalysis 下载免费PDF全文
Dr. Diego Núñez‐Villanueva Dr. M. Ángeles Bonache Laura Lozano Dr. Lourdes Infantes Prof. José Elguero Prof. Ibon Alkorta Prof. M. Teresa García‐López Dr. Rosario González‐Muñiz Dr. Mercedes Martín‐Martínez 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(6):2489-2500
Enantiopure β‐amino acids represent interesting scaffolds for peptidomimetics, foldamers and bioactive compounds. However, the synthesis of highly substituted analogues is still a major challenge. Herein, we describe the spontaneous rearrangement of 4‐carboxy‐2‐oxoazepane α,α‐amino acids to lead to 2′‐oxopiperidine‐containing β2,3,3‐amino acids, upon basic or acid hydrolysis of the 2‐oxoazepane α,α‐amino acid ester. Under acidic conditions, a totally stereoselective synthetic route has been developed. The reordering process involved the spontaneous breakdown of an amide bond, which typically requires strong conditions, and the formation of a new bond leading to the six‐membered heterocycle. A quantum mechanical study was carried out to obtain insight into the remarkable ease of this rearrangement, which occurs at room temperature, either in solution or upon storage of the 4‐carboxylic acid substituted 2‐oxoazepane derivatives. This theoretical study suggests that the rearrangement process occurs through a concerted mechanism, in which the energy of the transition states can be lowered by the participation of a catalytic water molecule. Interestingly, it also suggested a role for the carboxylic acid at position 4 of the 2‐oxoazepane ring, which facilitates this rearrangement, participating directly in the intramolecular catalysis. 相似文献
8.
9.
10.