Nonlocal Problem for a System of Partial Differential Equations of Higher Order with Pulsed Actions

Ukrainian Mathematical Journal - We consider a nonlocal problem for a system of partial differential equations of higher order with pulsed actions. By introducing new unknown functions, the...     

Energy dependence of optical-model parameters for the interaction of 6Li and 7Li Ions with 28Si nuclei at low energies

The results of a joint analysis of experimental data (angular distributions for scattering and total reaction cross sections) are presented for the case of the interaction of ^6,7Li ions with ²⁸Si nuclei at energies between 7.5 and 32 MeV. The respective calculations were performed on the basis of a deformed potential of the optical model by using the SPI-GENOA code. The energy dependences of the parameters of the macroscopic optical model and the total cross section for the (^6,7Li+²⁸Si) reactions were obtained over the energy interval from 7.5 to 32 MeV. The calculated angular distributions and total reaction cross sections are in good agreement with experimental data.     

Cytoprotective Activity of Newly Synthesized 3-(Arylmethylamino)-6-Methyl-4-Phenylpyridin-2(1H)-Ones Derivatives

Currently, studies are being conducted on the possible role of the cytoprotective effect of biologically active substances in conditions of cerebral hypoxia or cardiomyopathies. At the same time, oxidative stress is considered one of the important mechanisms of cellular cytotoxicity and a target for the action of cytoprotectors. The aim of this study is to search for derivatives of 3-(arylmethylamino)-6-methyl-4-phenylpyridin-2(1H)-ones. The probability of cytoprotective action was assessed by measuring cell viability using two tests (with neutral red dye and MTT test). It was found that some derivatives of 3-(arylmethylamino)-6-methyl-4-phenylpyridin-2(1H)-ones under the conditions of our experiment had a pronounced cytoprotective activity, providing better cell survival in vitro, including the MTT test and conditions of blood hyperviscosity. To correlate the obtained results in vitro, molecular docking of the synthesized derivatives was also carried out. The standard drug omeprazole (co-crystallized with the enzyme) was used as a standard. It was shown that all synthesized derivatives of 3-(arylmethylamino)-6-methyl-4-phenylpyridin-2(1H)-ones had higher affinity for the selected protein than the standard gastro-cytoprotector omeprazole. The studied derivatives of 3-(arylmethylamino)-6-methyl-4-phenylpyridin-2(1H)-ones also fully satisfy Lipinski’s rule of five (RO5), which increases their chances for possible use as orally active drugs with good absorption ability and moderate lipophilicity. Thus, the results obtained make it possible to evaluate derivatives of 3-(arylmethylamino)-6-methyl-4-phenylpyridin-2(1H)-ones as having a relatively high cytoprotective potential.