面向化妆品产业升级的江南大学应用化学专业建设思考与实践

Based on the development prospect of cosmetics industry, the advantage of light industry characteristic and the foundation of applied chemistry in Jiangnan University, a systematic upgrading of applied chemistry was carried out through "emerging engineering education (3E)" project "upgrade and practice of chemistry-related majors of local and/or trade university responding to the social developments" supported by the Ministry of Education. On the basis of investigation and analysis, the orientation and training goal of applied chemistry were updated first, and then the curriculum system was determined and the curriculum construction is strengthened, so as to achieve more distinctive characteristics, more solid foundation and more comprehensive quality. In view of the new requirements of the 3E for talent training, some practices have been formed in the aspects of multi-disciplinary integration, multi-angle coordination and close integration to industry. Contributing the development of cosmetics industry and seizing the commanding point of science and technology from the perspective of talent training, will play a unique role in human social progress.     

Isolation and purification of honokiol and magnolol from cortex Magnoliae officinalis by high-speed counter-current chromatography

High-speed counter-current chromatography was used to isolate and purify honokiol and magnolol from cortex Magnoliae Officinalis (Magnolia officinalis Rehd. et Wils.), a plant used in the traditional Chinese medicine. A crude sample, 150 mg, was successfully separated with a two-phase solvent system composed of n-hexane-ethyl acetate-methanol-water (1:0.4:1:0.4, v/v), and the fractions were analyzed by high-performance liquid chromatography. The separation produced 80 and 45 mg of honokiol and magnolol with purities of 99.2 and 98.2%, respectively, in 2.5 h.     

Blue-phase liquid crystal display with insulating protrusion

In order to lower the saturation voltage and enhance the transmittance of in-plane switching blue-phase liquid crystal display (IPS-BPLCD), IPS-BPLCD with insulating protrusion is proposed. The single-protrusion (only set on the top of pixel electrode) and double-protrusion (set on the top of pixel and common electrodes) structures are investigated in this work. The potential distribution changes when the protrusion is used. There is a thicker transverse electric field in BPLC range, because the stronger electric field at the edges of the electrodes is decentralised into BPLC range. As a result, the saturation voltage is reduced from 36.3 V to 28.9 V when the double-protrusion structure is used, and transmittance is increased by ~20%. The contrast ratio is larger than 1000:1 in 60° viewing cone using a half-wave biaxial film. Both single-protrusion and double-protrusion structures have the uniform gamma curves at large oblique viewing angles. Moreover, the off-axis image distortion index is 0.1590 at 60º polar angle when zigzag electrodes are used.     

A Potential Method Using Ge{iPrNC[N(SiMe3)2]NiPr}2, (Et3Si)2Te and Anhydrous Hydrazine for Germanium Tellurides

A germanium(II)‐guanidine derivative of formula Ge{iPrNC[N(SiMe₃)₂]NiPr}₂ ( 1 ) was synthesized and characterized by ¹H NMR, ¹³C NMR, elemental analysis, and X‐ray diffraction method. Thermal property was also studied to identify its thermal stability and volatility. More importantly, compound 1 was synthesized to develop a new method for germanium tellurides, where anhydrous hydrazine was introduced to prompt the activity of germanium(II) guanidines (or derivatives) towards (Et₃Si)₂Te. Solution reaction of compound 1 , (Et₃Si)₂Te, and anhydrous hydrazine was investigated to pre‐identify the feasibility of this combination for ALD process. The EDS data of the black precipitate from this reaction verified the potential of this method to manufacture germanium tellurides.     

The stress birefringence images of low angle grain boundaries in 6H‐SiC single crystals

Low angle grain boundaries, also referred to as domain walls, is one of the major structural defects in c‐axis physical vapor transport (PVT) grown hexagonal Silicon Carbide. To investigate the nature of the low angle boundaries, polarized optical microscope was used. The low angle boundary gives bright stress birefringence images under polarizing optical microscope. Periodic extinction of the stress birefringence images occurs when the (0001)‐face SiC is rotated under polarizing optical microscope. The micro‐structure of the low angle boundary is proposed. Using dislocation elastic theory, it is theoretically confirmed that the domains consist of uniform pure edge dislocations with Burgers vectors perpendicular to the dislocation arrays. The simulation results coincide with the experimental observations.     

非线性利率模型的分枝过程逼近

章主要证明了状态相依的分枝过程序列的一个极限定理, 结果表明非线性利率期限结构模型可以通过状态相依分枝过程的极限方式得到.     

Access to the structures of fluoromagnesium compounds: synthesis and structural characterization of the β-diketiminato magnesium fluoride [{CH(CMeNAr)2}Mg(μ-F)(THF)]2·toluene

β-Diketiminato magnesium fluoride [{CH(CMeNAr)₂}Mg(μ-F)(THF)]₂·toluene (Ar=2,6-i-Pr₂C₆H₃, 2·toluene) was synthesized. The molecular structure of 2 revealed for the first time, the double fluoro bridge feature between the two magnesium atoms with a typical MgF bond length (average 1.95 Å).     

A ratiometric near-infrared naphthalimide-based fluorescent probe with high sensitivity for detecting Fe2+ in vivo

Iron is one of the essential trace elements in the human body. It plays an important role in human biology and pathology. Deregulation of iron levels in cells is associated with disease development. In this work, we synthesized a novel near-infrared intramolecular charge transfer (ICT) based ratiometric fluorescent probe to detect Fe²⁺, by using naphthalimide and indole moieties as building blocks. Our work showed that the radiometric probe has excellent selectivity, sensitivity and rapid response. Moreover, we could successfully perform real-time monitoring of Fe²⁺ in HeLa cells and C. elegans.     

3-Oxodapagliflozin as a Potent and Highly Selective SGLT2 Inhibitor for the Treatment of Type 2 Diabetes

Structural modifications of 3-OH in the glucose moiety of dapagliflozin（1）, an approved potent sodium-dependent glucose transporter 2（SGLT2） inhibitor, led to 3-oxodapagliflozin（16）, a highly potent and more selective SGLT2 inhibitor[IC50（hSGLT1）/IC50（hSGLT2）=2851 for compound 16 vs. 843 for compound 1]. 3-Oxodapagliflozin（16） exhibited in vitro（IC50=1.0nmol/L against hSGLT2 for compound 16 vs. 1.3 nmol/L for compound 1） and in vivo activities comparable to those of dapagliflozin（1）. The bioactivities of 3-oxodapagliflozin （16） warrant its further evaluation as a promising SGLT2 inhibitor for the treatment of type 2 diabetes.     

新工科项目“地方(行业)高校化学类专业应对产业变化的升级改造研究与实践”的实施

This "emerging engineering education (3E)" project "Upgrade and Practice of Chemistry-related Majors of Local and/or Specialized University Responding to the Industry Changes" was supported by the Ministry of Education. To aim at the issue of how to upgrade the chemistry-related majors of a local and/or specialized university responding to industry changes, an investigation on local regional economy and industry changes was carried out, the capability requirements of 3E for talents were analyzed, and the training objectives, graduation requirements as well as the new teaching models were also studied for the major to meet the future requirements. The practical experience for 3E construction of chemistry-related majors by selected universities was suggested.