Analytical Treatment of a Push–Pull “Echo” Test

A semi-analytical streamline-based model, employing stratification and macro physics only, is developed and utilized to simulate injection/production phases of single-well push–pull tests. Modeling results are compared with experimental field data, giving an excellent match, without resorting to parameter fitting, simply by putting in known test-site properties, such as stratification data, hydraulic head gradients, and test parameters.     

On the Loss of Injectant and Apparent Dispersivity in Single-Well Push-Pull Tests Influenced by Natural Drift

In a previous article, a semi-analytical stream-line based model was developed for single-well push-pull tests in stratified reservoirs subject to natural drift. Based on that model, this article gives the theoretical maximum injection phase duration giving conservative injectant production, in a single-layer reservoir with natural drift. In addition, an analytical expression for the single-layer apparent dispersivity due to natural drift is given. Finally, it is shown how the large-scale apparent dispersivities observed in experimental data from a stratified aquifer may be predicted by constructing a production profile using the estimated single-layer apparent dispersivities.     

New candidaspongiolides, tedanolide analogues that selectively inhibit melanoma cell growth

Extracts of the sponge genus Candidaspongia showed selective cytotoxicity toward melanoma cells in the NCI 60-cell-line screen. Continued investigation of the Candidaspongia sp. extracts led to the isolation of three new tedanolide analogues, precandidaspongiolides A (1) and B (2) and candidaspongiolide B (4), as well as candidaspongiolide A (3) and tedanolide (5). Semisynthetic derivatives were also generated to develop SAR. Candidaspongiolides A/B were the most potent and showed low nanomolar activity against several melanoma cell lines.     

Kalk

Ohne Zusammenfassung     

Visualization of pigment distributions in paintings using synchrotron K-edge imaging

X-ray radiography plays an important role in the study of artworks and archaeological artifacts. The internal structure of objects provides information on genesis, authenticity, painting technique, material condition and conservation history. Transmission radiography, however, does not provide information on the exact elemental composition of objects and heavy metal layers can shadow or obscure the ones including lighter elements. This paper presents the first application of synchrotron-based K-edge absorption imaging applied to paintings. Using highly monochromatic radiation, K-edge imaging is used to obtain elemental distribution images over large areas. Such elemental maps visualize the distribution of an individual pigment throughout the paint stratigraphy. This provides color information on hidden paint layers, which is of great relevance to art historians and painting conservators. The main advantage is the quick data acquisition time and the sensitivity to elements throughout the entire paint stratigraphy. The examination of a test painting is shown and further instrumental developments are discussed. PACS 07.85.Qe; 07.05.Pj     

Comparison of simplified models for nitramine propellant combustion

Although 1,3,5-Trinitroperhydro-1,3,5-triazine (RDX) and Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) are very similar molecularly and their burning rates as a function of pressure are nearly identical, it is well known that they differ significantly in temperature sensitivity, especially at low pressures. To understand these differences better, three simple models were applied to HMX and RDX combustion. Both the Denison–Baum–Williams and Li–Williams–Margolis models have previously been calibrated for use with RDX. However, the RDX calibration of the Ward–Son–Brewster model was developed in the present work. All three models were compared with relevant measured data including: burning rate, flame stand-off/thickness, combustion stability, and temperature sensitivity. It was shown that all models are capable of accurately determining the burning rate of HMX and RDX as a function of pressure at the baseline initial temperature, but only two of the models are capable of capturing the variation in temperature sensitivity for both HMX and RDX, and only one model can replicate all the other measured characteristics within experimental uncertainty. Analysis using this model suggests that the surface reaction of RDX is much less exothermic than HMX and that there is a shifting between the gas phase and surface reaction dominance with pressure for HMX. This explains why the temperature sensitivity for RDX is nearly flat for low pressures while the temperature sensitivity for HMX increases significantly as the pressure decreases. Importantly, these trends are achieved without adding significant model complexity or having parameters change with pressure or initial temperature.     

Gas Condensate Relative Permeability for Well Calculations

This paper addresses several issues related to the modeling and experimental design of relative permeabilities used for simulating gas condensate well deliverability. Based on the properties of compositional flow equations, we make use of the fact that relative permeability ratio k _rg/k _ro is a purely thermodynamic variable, replacing saturation, when flow is steady-state. The key relation defining steady-state flow in gas condensate wells is relative permeability k _rg as a function of k _rg/k _ro. Consequently, determination of saturation and k _r as a function of saturation is not important for this specific calculation. Once the k _rg=f(k _rg/k _ro) relationship is experimentally established and correlated with capillary number (N _c), accurate modeling of condensate blockage is possible. A generalized model is developed for relative permeability as the function of k _rg/k _ro and capillary number. This model enables us to link the immiscible or rock curves with miscible or 'straight-line curves by a transition function dependent on the capillary number. This model is also extended to the case of high-rate, inertial gas flow within the steady-state condensate blockage regionand locally at the wellbore. We have paid particular attention to the effect of hysteresis on the relation k _rg=f(k _rg/k _ro), based on our observation that many repeated cycles of partial/complete imbibition and drainage occur in the near-well region during the life of a gas condensate well. Finally, the composite effect of condensate blockage is handled using a Muskat pseudopressure model, where relative permeabilities are corrected for the positive effect of capillary number dependence and the negative effect of inertial high velocity flow. Special steady-state experimental procedures have been developed to measure k _rg as a function of k _rg/k _ro and N _c. Saturations, though they can be measured, are not necessary. An approach for fitting steady-state gas condensate relative permeability data has been developed and used for modeling relative permeability curves.     

Challenge of large-scale motion for residual dipolar coupling based analysis of configuration: the case of fibrosterol sulfate A

Fibrosterol sulfate A is a polysulfated bis-steroid with an atypical side chain. Due to the flexibility of the linker, large-scale motions that change dramatically the shape of the entire molecule are expected. Such motions pose major challenges to the structure elucidation and the correct determination of configuration. In this study, we will describe the determination of the relative configuration of fibrosterol sulfate A through a residual dipolar coupling based multiple alignment tensor analysis complemented by molecular dynamics. For completeness, we applied also the single tensor approach which is unreliable due to the large-scale motions and compare the results.