A novel isomerization on interaction of antitumor-active azole-bridged dinuclear platinum(II) complexes with 9-ethylguanine. Platinum(II) atom migration from N2 to N3 on 1,2,3-triazole

The reactions of the dinuclear platinum(II) complexes, [[cis-Pt(NH(3))(2)](2)(mu-OH)(mu-pz)](NO(3))(2) (1, pz = pyrazolate), [[cis-Pt(NH(3))(2)](2)(mu-OH)(mu-1,2,3-ta-N1,N2)](NO(3))(2) (2, 1,2,3-ta = 1,2,3-triazolate), and a newly prepared [[cis-Pt(NH(3))(2)](2)(mu-OH)(mu-4-phe-1,2,3-ta-N1,N2)](NO(3))(2) (3, 4-phe-1,2,3-ta = 4-phenyl-1,2,3-triazolate), whose crystal structure was determined, with 9-ethylguanine (9EtG) have been monitored in aqueous solution at 310 K by means of (1)H NMR spectroscopy. The dinuclear platinum(II) complexes 1-3 each react with 9EtG in a bifunctional way to form 1:2 complexes, [[cis-Pt(NH(3))(2)(9EtG-N7)](2)(mu-pz)](3+) (4), [[cis-Pt(NH(3))(2)(9EtG-N7)](2)(mu-1,2,3-ta-N1,N3)](3+) (5), and [[cis-Pt(NH(3))(2)(9EtG-N7)](2)(mu-4-phe-1,2,3-ta-N1,N3)](3+) (6). The reactions of 2 and 3 involve a novel isomerization, in which the Pt atom, initially bound to N2 on the 1,2,3-ta, migrates to N3 after the first substitution by N7 of 9EtG. This isomerization reaction has been unambiguously characterized by 1D and 2D NMR spectroscopy and pH titration. The reactions of 2 and 3 with 9EtG show faster kinetics, and the second-order rate constants (k) for the reactions of 1-3are 1.57 x 10(-4), 2.53 x 10(-4), and 2.56 x 10(-4) M(-1) s(-1), respectively. The pK(a) values at the N1H site of 9EtG were determined for 4-6 from the pH titration curves. Cytotoxicity assays of 1-3 were performed in L1210 murine leukemia cell lines, respectively sensitive and resistant to cisplatin. In the parent cell line, 2 and 3 exhibit higher cytotoxicity compared to cisplatin, especially, 2 is 10 times as active as cisplatin. 1 was found to be less cytotoxic than cisplatin, but still in the active range and more active than cisplatin in a cisplatin-resistant cell line.     

用于高分辨率 PET探测器的LSO闪烁晶体的研究

LSO晶体具有密度大光输出量强和衰减时间短的特性使其成为在PET探测器领域的应用潜在的闪烁晶体材料.按照辐射成象系统应用的性能要求我们对LSO晶体的闪烁特性进行了评价.为了获取较高的光输出量,研究和验证了许许多多的晶体表面的状况对光输出量的影响.对于单个LSO晶体和R5900-00-C12位敏管相耦合的系统,钠伽马射线源的511keV的能量峰处的能量分辨率为15%,时间分辨率为0.65ns,最后对三个LSO阵列分别成象验证了其空间分辨本领.     

Lattice Boltzmann simulation of the dispersion of aggregated Brownian particles under shear flows

The deformation and breakup processes of a particle-cluster aggregate under shear flows are investigated by the two-phase lattice Boltzmann method. In the simulation the particle is modeled by a hard droplet with large viscosity and strong surface tension. The van der Waals attraction force is taken into account for the interaction between the particles. Also, the Brownian motion is considered for nano-particles. Two important dimensionless parameters are introduced in order to classify calculated results. One is the ratio of fluid force to the maximum inter-particle force, Y, and the other is the Péclet number which is the ratio of the rate of diffusion by a shear flow to the rate of diffusion by Brownian motion. It is found that Y is the key factor in dispersion and that the Brownian motion retards the dispersion.     

Neodolabelline,a methyl migrated dolabellane-type diterpene from the okinawan soft coral clavularia koellikeri

A new diterpene named neodolabelline (5), having a methyl migrated dolabellane-type skeleton, was isolated from the stoloniferan soft coral Clavularia koellikeri, together with clavukerins (trinor-sesquiterpenes) and bicyclo-germacrene, and the absolute configuration was determined.     

新型位置灵敏光电倍增管的性能测量

位置灵敏型光电倍增管(PS-PMT)代表了基于单个管子的原理开发新概念γ相机的技术进步.最近,日本滨松公司出品了一种新型紧凑型的PSPMT—R7600-C12.根据正电子放射断层成像系统(PET)的应用特点,我们测试了由该PS-PMT组合成的闪烁晶体阵列探测器的空间分辨率、空间线性度、增益均匀性及时间分辨率LSO与该PS-PMT的组合空间分辨率达到1.4mm,而且显示出良好的空间线性、增益均匀性及优异的时间分辨特性.     

Fluid flow in a rotating cylindrical container with a rotating disk at the fluid surface

Fluid flow in a rotating cylindrical container of radius R_w and height H with a co-axially rotating disk of radius R_d at the fluid surface is numerically investigated. The container and the disk rotate with angular velocities Ω_w and Ω_d, respectively. We solve the axisymmetric Navier-Stokes equations using a finite-volume method. The effects of the relative directions and magnitudes of the disk and container rotations are studied. The calculations are carried out with various ratios of Ω_w and Ω_d for H/R_w = 2 and R_d/R_w = 0.7. Streamlines and velocity vectors in the meridional plane and azimuthal velocities are obtained. The flow fields in the meridional plane are discussed with relation to azimuthal velocities in the interior of the container. The numerical results are also compared with experimental data.     

Numerical simulations of gas-liquid two-phase flows in a micro porous structure

The lattice Boltzmann method for two-phase fluid flows is applied to the simulations of gas-liquid two-phase flows in a micro porous structure for various capillary numbers at low Reynolds numbers. The behaviors of the gas-liquid interface and the velocities of the two-phase fluid in the structure are simulated, and the permeability of gas and liquid through the structure are estimated from the calculated results. By changing the void fraction, the contact angle of the interface on walls, and the surface tension, the effect of these properties on the behaviors and the permeability of the two-phase flows in the micro porous structure is investigated. It is found that the permeability of liquid flows depends on the contact angle and it increases for hydrophobic walls. It is also seen that liquid flows are choked in pores for large void fractions and low capillary numbers.