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Di Giamberardino Paolo Iacoviello Daniela Papa Federico Sinisgalli Carmela 《Nonlinear dynamics》2021,106(2):1239-1266
Nonlinear Dynamics - An epidemic multi-group model formed by interconnected SEIR-like structures is formulated and used for data fitting to gain insight into the COVID-19 dynamics and into the role... 相似文献
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O. Arino A. Gandolfi C. Sinisgalli 《Journal of Mathematical Analysis and Applications》2005,302(2):521-542
A continuous cell population model, which represents both the cell cycle phase structure and the kinetic heterogeneity of the population following Shackney's ideas [J. Theor. Biol. 38 (1973) 305-333], is studied. The asynchronous exponential growth property is proved in the framework of the theory of strongly continuous semigroups of bounded linear operators. 相似文献
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Maria Ponticelli Ludovica Lela Daniela Russo Immacolata Faraone Chiara Sinisgalli Mayssa Ben Mustapha Germana Esposito Hichem Ben Jannet Valeria Costantino Luigi Milella 《Molecules (Basel, Switzerland)》2022,27(3)
Dittrichia graveolens L. Greuter belonging to the Asteraceae family, is an aromatic herbaceous plant native to the Mediterranean region. This plant species has been extensively studied for its biological activities, including antioxidant, antitumor, antimicrobial, antifungal, anti-inflammatory, anticholinesterase, and antityrosinase, and for its peculiar metabolic profile. In particular, bioactivities are related to terpenes and flavonoids metabolites, such as borneol (40), tomentosin (189), inuviscolide (204). However, D. graveolens is also well known for causing health problems both in animals and humans. Moreover, the species is currently undergoing a dramatic northward expansion of its native range related to climate change, now including North Europe, California, and Australia. This review represents an updated overview of the 52 literature papers published in Scopus and PubMed dealing with expansion, chemistry (262 different compounds), pharmacological effects, and toxicology of D. graveolens up to October 2021. The review is intended to boost further studies to determine the molecular pathways involved in the observed activities, bioavailability, and clinical studies to explore new potential applications. 相似文献
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Fabiana Giglio Maria Antonietta Castiglione Morelli Ilenia Matera Chiara Sinisgalli Rocco Rossano Angela Ostuni 《Molecules (Basel, Switzerland)》2021,26(2)
Muscari comosum L. bulbs are commonly used as food in South Italy and also in folk medicine. By evaluating in vitro antioxidant activity and biological activities of their aqueous and methanol extracts, we shed light on the potential role, including both the nutraceutical and health benefits, of this plant. Total polyphenol content (TPC) and total flavonoid content (TFC) were evaluated by the Folin–Ciocalteu method and by the aluminum chloride method, respectively. Antioxidant activity was investigated by three in vitro assays and relative antioxidant capacity index (RACI) was calculated to compare results obtained by different tests. The extracts were tested to evaluate their possible involvement in redox homeostasis, using the human hepatoma (HepG2) cell line used as model. The extracts exhibited concentration/solvent dependent radical scavenging activity, as well as dysregulation of some genes involved in redox pathways by promoting Nrf2, SOD-2, GPX1, ABCC6 and ABCG2 expression. NMR metabolomics analysis suggests that HepG2 cells treated with Muscari comosum extracts experience changes in some metabolites involved in various metabolic pathways. 相似文献
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