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Dr. Giulia Foschi Dr. Cristiano Albonetti Dr. Fabiola Liscio Dr. Silvia Milita Dr. Pierpaolo Greco Prof. Fabio Biscarini 《Chemphyschem》2015,16(16):3379-3384
The amorphous aggregation of Aβ1‐40 peptide is addressed by using micromolding in capillaries. Both the morphology and the size of the aggregates are modulated by changing the contact angle of the sub‐micrometric channel walls. Upon decreasing the hydrophilicity of the channels, the aggregates change their morphology from small aligned drops to discontinuous lines, thereby keeping their amorphous structure. Aβ1‐40 fibrils are observed at high contact angles. 相似文献
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A symbolic algorithm based on the generalized Lucas polynomials of first kind is used in order to compute the Newton sum rules for the zeros of polynomial eigenfunctions of linear differential operators with polynomial coefficients. 相似文献
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In conformal geometry, the Compactness Conjecture asserts that the set of Yamabe metrics on a smooth, compact, aspherical Riemannian manifold $\left( M,g\right) $ is compact. Established in the locally conformally flat case by Schoen (Lecture Notes in Mathematics, vol. 1365, pp. 120–154. Springer, Berlin 1989, Surveys Pure Application and Mathematics, 52 Longman Science, Technology, pp. 311–320. Harlow 1991) and for $n\le 24$ by Khuri–Marques–Schoen (J Differ Geom 81(1):143–196, 2009), it has revealed to be generally false for $n\ge 25$ as shown by Brendle (J Am Math Soc 21(4):951–979, 2008) and Brendle–Marques (J Differ Geom 81(2):225–250, 2009). A stronger version of it, the compactness under perturbations of the Yamabe equation, is addressed here with respect to the linear geometric potential $\frac{n-2}{4(n-1)} {{\mathrm{Scal}}}_g,\, {{\mathrm{Scal}}}_g$ being the Scalar curvature of $\left( M,g\right) $ . We show that a-priori $L^\infty $ –bounds fail for linear perturbations on all manifolds with $n\ge 4$ as well as a-priori gradient $L^2$ –bounds fail for non-locally conformally flat manifolds with $n\ge 6$ and for locally conformally flat manifolds with $n\ge 7$ . In several situations, the results are optimal. Our proof combines a finite dimensional reduction and the construction of a suitable ansatz for the solutions generated by a family of varying metrics in the conformal class of $g$ . 相似文献
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Biological adaptation assumes the evolution of structures toward better functions. Yet, the roots of adaptive trajectories usually entail subverted—perverted—structures, derived from a different function: what Gould and Vrba called “exaptation.” Generally, this derivation is regarded as contingent or serendipitous, but it also may have regularities, if not rules, in both biological evolution and technological innovation. On the basis of biological examples and examples from the history of technology, the authors demonstrate the centrality of exaptation for a modern understanding of niche, selection, and environment. In some cases, biological understanding illuminates technical exaptation. Thus, the driver of exaptation is not simply chance matching of function and form; it depends on particular, permissive contexts. © 2013 Wiley Periodicals, Inc. Complexity 18: 7–14, 2013 相似文献
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This paper addresses the topic of classifying financial time series in a fuzzy framework proposing two fuzzy clustering models both based on GARCH models. In general clustering of financial time series, due to their peculiar features, needs the definition of suitable distance measures. At this aim, the first fuzzy clustering model exploits the autoregressive representation of GARCH models and employs, in the framework of a partitioning around medoids algorithm, the classical autoregressive metric. The second fuzzy clustering model, also based on partitioning around medoids algorithm, uses the Caiado distance, a Mahalanobis-like distance, based on estimated GARCH parameters and covariances that takes into account the information about the volatility structure of time series. In order to illustrate the merits of the proposed fuzzy approaches an application to the problem of classifying 29 time series of Euro exchange rates against international currencies is presented and discussed, also comparing the fuzzy models with their crisp version. 相似文献
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We study the branch of semistable and unstable solutions (i.e., those whose Morse index is at most 1) of the Dirichlet boundary value problem ? Δu = λf(x)/(1 ? u)2 on a bounded domain Ω ? ?N, which models—among other things—a simple electrostatic microelectromechanical system (MEMS) device. We extend the results of 11 relating to the minimal branch, by obtaining compactness along unstable branches for 1 ≤ N ≤ 7 on any domain Ω and for a large class of “permittivity profiles” f. We also show the remarkable fact that powerlike profiles f(x) ? |x|α can push back the critical dimension N = 7 of this problem by establishing compactness for the semistable branch on the unit ball, also for N ≥ 8 and as long as As a byproduct, we are able to follow the second branch of the bifurcation diagram and prove the existence of a second solution for λ in a natural range. In all these results, the conditions on the space dimension and on the power of the profile are essentially sharp. © 2007 Wiley Periodicals, Inc. 相似文献