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排序方式: 共有238条查询结果,搜索用时 233 毫秒
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Molecular self-assembly is an intrinsic property of proteins central to their biological functionality. One important industrially interesting property is the ability to control and switch on and off self-assembly using a variety of external chemical and physical triggers. Model peptides have been developed with significantly reduced chemical and structural complexity compared to biological proteins. These are ideal systems for exposing the fundamental principles that drive protein-like self-assembly, as well as for establishing in a quantitative manner their structure-function relationship. We investigate simple, short model peptides that adopt a purely β-strand conformation, align in an antiparallel manner and self-assemble in one dimension in solution into long β-sheet nanotapes and higher order aggregates with no other conformation (i.e., helices, turns or random coils) present in the aggregates. These micrometre-long nanostructures gel in solutions at concentrations as low as 0.2% v/v. Their gel-fluid transition has been previously shown to be controlled by pH, temperature, or by mixing with complementary peptides. Here we show the dramatic effect of another chemical trigger, that of physiological-like salt concentration, on the self-assembly, morphology and gelation of a series of systematically designed charged self-assembling tape-forming peptides, each 11 amino acid residues in length, in the pH range of 2-14. This study provides a detailed understanding of the self-assembly of this class of peptides in aqueous solutions of biologically relevant pH and ionic strength. This insight has led to the development of injectable self-assembling peptide lubricants as potential therapeutics for the treatment of early stage knee joint osteoarthritis. 相似文献
3.
A Monte Carlo study has been made of commensurate-incommensurate behaviour for Lennard-Jones particles on a square commensurate lattice. For a fixed barrier height a pronounced minimum is found in plots of R, the mean distance of the particles from the nearest commensurate site, against ε*, where ε* is the depth of the potential well. The initial fall in R with increase in ε* is shown to be associated with the repulsive part of the inter-particle interaction. 相似文献
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Symmetrical polymethoxyanthracenes are rapidly made and easily isolated in moderate yield by treatment of appropriately substituted (methoxy)n halobenzenes with lithium 2,2,6,6-tetramethylpiperidide (LTMP) in refluxing THF. 相似文献
6.
Neville Boden Richard J. Bushby Kevin Donovan Quanying Liu Zhibao Lu Theo Kreouzis 《Liquid crystals》2013,40(12):1739-1748
A synthesis has been developed for 2,3,7,8,12,13-hexakis[2-(2-methoxyethoxy)ethoxy]-tricycloquinazoline (TCQ6EO2M) in which the ethylenoxy side chains are introduced before elaboration of the heterocylic core. This discogen gives a hexagonal columnar phase (Colh) between 77 and 233°C. n-Doping using potassium metal is facilitated firstly by the electron poor/π-deficient nature of the core and secondly by the polyethylenoxy side chains which complex the potassium K+ counter-ions. The conductivity of the Colh phase of TCQ6EO2M doped with 10 mol % potassium (σ ∥ = 1.1 x 10-3 S m-1) is substantially higher than that previously reported for 2,3,7,8,12,13-hexa(hexylthio)tricycloquinazoline doped with 6 mol % potassium (σ ∥ = 2.9 x 10-5 S m-1). Photoconductivity studies of TCQ6EO2M using a time of flight sample configuration show transient photocurrents for both holes and electrons. From these an upper limit on the mobility for the electrons is estimated as ~10-4 cm2 V-1 s-1 at 150°C which is of the same magnitude as that for hole mobilities in other columnar discotic liquid crystals. 相似文献
7.
Siegfried E. Drewes Owen L. Njamela Neville D. Emslie Niyum Ramesar John S. Field 《合成通讯》2013,43(20):2807-2815
The acrylate ester of salicylaldehyde, in the presence of DABCO, affords a crystalline coumarin salt. Formation of this derivative confirms a vital intermediate in the mechanism of the reaction. Salicylaldehyde, suitably protected, reacts with methyl acrylate to afford a novel coumarin not unlike the vasodilator chromonar. 相似文献
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Mario Caruana Angelique Camilleri Maria Ylenia Farrugia Stephanie Ghio Michaela Jakubí
kov Ruben J. Cauchi Neville Vassallo 《Molecules (Basel, Switzerland)》2021,26(5)
The identification of compounds which protect the double-membrane of mitochondrial organelles from disruption by toxic confomers of amyloid proteins may offer a therapeutic strategy to combat human neurodegenerative diseases. Here, we exploited an extract from the marine brown seaweed Padina pavonica (PPE) as a vital source of natural bioactive compounds to protect mitochondrial membranes against insult by oligomeric aggregates of the amyloidogenic proteins amyloid-β (Aβ), α-synuclein (α-syn) and tau, which are currently considered to be major targets for drug discovery in Alzheimer’s disease (AD) and Parkinson’s disease (PD). We show that PPE manifested a significant inhibitory effect against swelling of isolated mitochondria exposed to the amyloid oligomers, and attenuated the release of cytochrome c from the mitochondria. Using cardiolipin-enriched synthetic lipid membranes, we also show that dye leakage from fluorophore-loaded vesicles and formation of channel-like pores in planar bilayer membranes are largely prevented by incubating the oligomeric aggregates with PPE. Lastly, we demonstrate that PPE curtails the ability of Aβ42 and α-syn monomers to self-assemble into larger β-aggregate structures, as well as potently disrupts their respective amyloid fibrils. In conclusion, the mito-protective and anti-aggregator biological activities of Padina pavonica extract may be of therapeutic value in neurodegenerative proteinopathies, such as AD and PD. 相似文献
10.
Pileio G Concistrè M McLean N Gansmüller A Brown RC Levitt MH 《Journal of magnetic resonance (San Diego, Calif. : 1997)》2007,186(1):65-74
Many important double-quantum recoupling techniques in solid-state NMR are classified as being gamma-encoded. This means that the phase of the double-quantum effective Hamiltonian, but not its amplitude, depends on the third Euler angle defining the orientation of the molecular spin system in the frame of the magic-angle-spinning rotor. In this paper, we provide closed analytical solutions for the dependence of the powder-average double-quantum-filtered signal on the recoupling times, within the average Hamiltonian approximation for gamma-encoded pulse sequences. The validity of the analytical solutions is tested by numerical simulations. The internuclear distance in a (13)C(2)-labelled retinal is estimated by fitting the analytical curves to experimental double-quantum data. 相似文献