Efficient synthesis and spectral determination of 11‐[(o‐ m‐ and p‐substituted)‐phenyl]‐8‐chloro‐3,3‐dimethyl‐2,3,4,5,10,11‐hexahydro‐1H‐dibenzo[b,e][1,4]diazepin‐1‐ones

A new synthesis to obtain eleven novel derivatives of 11‐[(o‐ m‐ and p‐substituted)‐phenyl]‐8‐chloro‐3,3‐dimethyl‐2,3,4,5,10,11‐hexahydro‐1H‐dibenzo[b,e][1,4]diazepin‐1‐ones with possible pharmacological activity in the central nervous system in two efficient steps has been developed. The final products were obtained by condensation and cyclization between 3‐[4‐chloro‐1,2‐phenylenediamine]‐5,5‐dimethyl‐2‐cyclohexenone with (o‐ m‐ and p‐substituted)benzaldehyde. The structure of all products was corroborated by ir, ¹H‐nmr, ¹³C‐nmr and high resolution in ms.     

Dynamical features of the solid motion in gas–solid risers

The trajectories of a solid tracer with the same characteristics as the circulating solids in the risers of two pilot-scale circulating fluidized beds (CFBs), obtained by the computer automated radioactive particle tracking (CARPT) technique, are examined in detail to get further insights into the complex solids dynamics of these systems. The analysis uses tools from the theory of non-linear dynamics and symbolic dynamics. Distinct features of the solids dynamics within the fast fluidization and the dilute phase transport flow regimes are highlighted and related to the operating conditions. The possibility of downflow cluster existence within the central region of the riser is particularly examined.     

Synthesis of Unsaturated Carboxylic and Amino Acids of Adamantane Series with the Use of Organophosphorus Reagents

Sodium derivative of diethyl(3-amino-1-ethoxycarbonylpropane)phosphonic acid was obtained by reaction of triethyl phosphonoacetate with ethylene imine in the presence of sodium hydride. The compound obtained was brought into Horner-Emmons reaction with carbonyl derivatives of adamantane series to afford the corresponding unsaturated amino acids. From adamantanecarbonyl chlorides and triphenylphosphonium ethoxycarbonylmethylide were prepared new phosphorus acylylides that on thermolysis provide ethyl acetylenecarboxylates containing an adamantyl substituent.