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排序方式: 共有136条查询结果,搜索用时 0 毫秒
1.
Qunying Jiang Min Pan Jialing Hu Junlin Sun Lei Fan Zhiqiao Zou Jianshuang Wei Xiaoquan Yang Xiaoqing Liu 《Chemical science》2021,12(1):148
Many cancer treatments including photodynamic therapy (PDT) utilize reactive oxygen species (ROS) to kill tumor cells. However, elevated antioxidant defense systems in cancer cells result in resistance to the therapy involving ROS. Here we describe a highly effective phototherapy through regulation of redox homeostasis with a biocompatible and versatile nanotherapeutic to inhibit tumor growth and metastasis. We systematically explore and exploit methylene blue adsorbed polydopamine nanoparticles as a targeted and precise nanocarrier, oxidative stress amplifier, photodynamic/photothermal agent, and multimodal probe for fluorescence, photothermal and photoacoustic imaging to enhance anti-tumor efficacy. Remarkably, following the glutathione-stimulated photosensitizer release to generate exogenous ROS, polydopamine eliminates the endogenous ROS scavenging system through depleting the primary antioxidant, thus amplifying the phototherapy and effectively suppressing tumor growth in vitro and in vivo. Furthermore, this approach enables a robust inhibition against breast cancer metastasis, as oxidative stress is a vital impediment to distant metastasis in tumor cells. Innovative, safe and effective nanotherapeutics via regulation of redox balance may provide a clinically relevant approach for cancer treatment.Amplified oxidative stress achieved by modulating redox homeostasis with PDA–MB for highly effective synergistic phototherapy to inhibit primary tumors and metastases. 相似文献
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3.
Ma Qiang Zhou Bingjie Feng Zhigang Bai Jialing Zhang Lanying Liu Wei 《Journal of Radioanalytical and Nuclear Chemistry》2022,331(5):2045-2054
Journal of Radioanalytical and Nuclear Chemistry - Soil radon anomaly is a common phenomenon in karst areas. In this paper, the geochemical behavior of radium (Ra) in the process of carbonate rock... 相似文献
4.
吸气式高超声速飞行器气动力气动热的数值模拟方法及应用 总被引:1,自引:0,他引:1
对吸气式高超声速飞行器而言,物面热流和摩阻的准确预测对飞行器设计及安全十分关键.介绍采用CFD准确预测气动力和气动热的方法,包括流动的控制方程、湍流模型及湍流的先进壁面函数边界条件,介绍流动的数值求解方法.对典型超声速层流和湍流流动的摩擦阻力和热流进行详细的验证与确认,考察CFD工具在使用先进壁面函数边界条件后,湍流计算的法向网格无关性能力.对设计的一种吸气式高超声速飞行器的气动力和气动热进行数值模拟,为飞行器的气动设计及热防护提供了可靠的数据. 相似文献
5.
The primary goal of this paper is to present a comprehensive study of the nonlinear Schr?dinger equations with combined nonlinearities of the power-type and Hartree-type. Under certain structural conditions, the authors are able to provide a complete picture of how the nonlinear Schr?dinger equations with combined nonlinearities interact in the given energy space. The method used in the paper is based upon the Morawetz estimates and perturbation principles. 相似文献
6.
Balakrishnan K Datar A Zhang W Yang X Naddo T Huang J Zuo J Yen M Moore JS Zang L 《Journal of the American Chemical Society》2006,128(20):6576-6577
Nanofibril structures have been fabricated from an arylene ethynylene macrocycle (AEM), which consists of a square frame corner-joined by four carbazole moieties. The fabrication was performed through a gelating process by cooling a warm, homogeneous solution in cyclohexane at high temperature (e.g., 100 degrees C) to room temperature. During the gelation, the molecules become organized, with optimal pi-pi stacking in cooperation with the side-chain association. The favorable pi-pi stacking facilitates the 1D growth of molecular assembly. 相似文献
7.
采用气相色谱法,建立了同时检测食品工业用大孔吸附树脂中的苯、1,2-二氯乙烷、甲苯、邻二甲苯、间二甲苯、对二甲苯、氯苯、苯乙烯、二乙烯苯、丙烯腈、甲基丙烯酸甲酯等11种有机残留物的方法。色谱柱为DB-WAX毛细柱,检测器为氢火焰离子化检测器,该方法的专属性强,在所考察的浓度范围内线性相关系数均在0.99以上,最低检出限为0.002~0.008μg/mL,样品加标回收率为72.4~104.7%,稳定性、精密度和重现性的RSD分别为1.68~5.26%、1.57~6.83%、2.91~9.62%。本方法具有简便易行、准确、稳定、快速等特点。 相似文献
8.
Both experimental and finite element model (FEM) results are presented for the dynamic strength behavior of windshield subjected
to bird impact. The experimental data taken from a series of high speed photographs are compared with the numerical results
predicted by using FEM in which the windshield was modeled entirely with solid elements and the bird body was approximately
simulated by an elastic-plastic material with failure element behavior. Effective plastic strain and element pressure were
adopted as the failure criteria and once the pressure or the effective plastic strain of an element reached the critical value,
the element would lose the tensile resistance capability completely. The deflection and stress distribution in the windshield
were obtained. It is shown that the result from the finite element analysis agrees with those from the full-scale bird impact
test.
The project supported by the National Natural Science Foundation of China (10272011) 相似文献
9.
超高效液相色谱-串联质谱法测定人尿液中全氟有机化合物 总被引:1,自引:0,他引:1
采用超高效液相色谱-串联质谱(UPLC-MS/MS)联用技术,建立了对人尿液中12种全氟有机化合物(PFCs)的分析方法。首先在尿液样品中加入相应的同位素内标,以2%(体积分数)甲酸甲醇溶液超声萃取、离心后,将提取液用弱阴离子交换固相萃取柱净化,采用UPLC-MS/MS测定,内标法定量。12种目标化合物在0.05~50 μg/L质量浓度范围内线性良好,相关系数(r)均大于0.992,检出限在0.44~3.47 ng/L之间。在20、100、500 ng/L添加水平下,平均回收率范围为80.3%~116.2%,相对标准偏差(n=6)在5.5%~13.8%之间。该方法灵敏度高、重现性好、回收率高、操作简单,适合人尿液中PFCs的测定。 相似文献
10.