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In the last decade, the characterization of transport in porous media has benefited largely from numerical advances in applied mathematics and from the increasing power of computers. However, the resolution of a transport problem often remains cumbersome, mostly because of the time-dependence of the equations and the numerical stability constraints imposed by their discretization. To avoid these difficulties, another approach is proposed based on the calculation of the temporal moments of a curve of concentration versus time. The transformation into the Laplace domain of the transport equations makes it possible to develop partial derivative equations for the calculation of complete moments or truncated moments between two finite times, and for any point of a bounded domain. The temporal moment equations are stationary equations, independent of time, and with weaker constraints on their stability and diffusion errors compared to the classical advection–dispersion equation, even with simple discrete numerical schemes. Following the complete theoretical development of these equations, they are compared firstly with analytical solutions for simple cases of transport and secondly with a well-performing transport model for advective–dispersive transport in a heterogeneous medium with rate-limited mass transfer between the free water and an immobile phase. Temporal moment equations have a common parametrization with transport equations in terms of their parameters and their spatial distribution on a grid of discretization. Therefore, they can be used to replace the transport equations and thus accelerate the achievement of studies in which a large number of simulations must be carried out, such as the inverse problem conditioned with transport data or for forecasting pollution hazards. 相似文献
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Natan Roberto de Barros Mohammad Ali Darabi Xin Ma Sibel Emir Diltemiz Menekse Ermis Alireza Hassani Najafabadi Sara Nadine Ethan A. Banton Kalpana Mandal Reza Abbasgholizadeh Natashya Falcone João F. Mano Rohollah Nasiri Rondinelli Donizetti Herculano Yangzhi Zhu Serge Ostrovidov Junmin Lee Han-Jun Kim Vahid Hosseini Mehmet R. Dokmeci Samad Ahadian Ali Khademhosseini 《Macromolecular bioscience》2023,23(12):2370037
Several microfabrication technologies have been used to engineer native-like skeletal muscle tissues. However, the successful development of muscle remains a significant challenge in the tissue engineering field. Muscle tissue engineering aims to combine muscle precursor cells aligned within a highly organized 3D structure and biological factors crucial to support cell differentiation and maturation into functional myotubes and myofibers. In this study, the use of 3D bioprinting is proposed for the fabrication of muscle tissues using gelatin methacryloyl (GelMA) incorporating sustained insulin-like growth factor-1 (IGF-1)-releasing microparticles and myoblast cells. This study hypothesizes that functional and mature myotubes will be obtained more efficiently using a bioink that can release IGF-1 sustainably for in vitro muscle engineering. Synthesized microfluidic-assisted polymeric microparticles demonstrate successful adsorption of IGF-1 and sustained release of IGF-1 at physiological pH for at least 21 days. Incorporating the IGF-1-releasing microparticles in the GelMA bioink assisted in promoting the alignment of myoblasts and differentiation into myotubes. Furthermore, the myotubes show spontaneous contraction in the muscle constructs bioprinted with IGF-1-releasing bioink. The proposed bioprinting strategy aims to improve the development of new therapies applied to the regeneration and maturation of muscle tissues. 相似文献
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