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1.
A new investigation of the active sponge extracts of Prosuberites laughlini collected off the West coast of Puerto Rico has yielded three new cyclic heptapeptides, namely euryjanicins E (1)–G (3), containing multiple phenylalanine and proline residues. In CDCl3 solution, each euryjanicin F (2) and G (3) exists as an inseparable complex mixture of conformational isomers. The molecular structures of 1–3 were elucidated by a combination of chemical degradation, extensive ESI-MS/MSn analyses, and 2D NMR methods. The elucidation of the absolute configuration was achieved by HPLC following analysis of the acid hydrolysates after derivatization with Marfey's reagent. When assayed against the National Cancer Institute 60 tumor cell line panel, the new cyclic peptides did not display significant in vitro cytotoxicity. 相似文献
2.
The Caribbean alcyonacean Pseudopterogorgia kallos is shown to contain a novel rearranged pseudopterane diterpene, kallosin A (1), possessing several unusual structural features. In addition to having two distinct 2(3H)- and 2(5H)-furanone moieties, kallosin A is based on a new carbon skeleton. The structural assignment of 1 was based mainly on 1D and 2D NMR spectral data and was further supported by accurate mass measurement and single-crystal X-ray diffraction analysis. 相似文献
3.
Jeffrey Marrero Abimael D. Rodríguez Peter Baran Scott G. Franzblau 《Tetrahedron》2006,62(29):6998-7008
Parallel chemical investigations of the hexane and chloroform extracts of the sea plumes Pseudopterogorgia bipinnata and Pseudopterogorgia kallos has led to the discovery of seven new diterpenoids of the pseudopterane class, namely, kallolide D (2), kallolide C acetate (3), kallolide E (4), kallolide F (5), kallolide G (6), kallolide H (7), and kallolide I (8), in addition to nine previously described compounds of the pseudopterane and gersolane families of diterpenes. The chemical structures of the new metabolites were established by 1D and 2D NMR, IR, UV, HRMS, and, in some instances, by single-crystal X-ray crystallographic analyses. Biological screening of these metabolites revealed significant anti-parasitic activity albeit marginal anti-tubercular activity. 相似文献
4.
Dithioketals are converted in good yields to vinyi sulfides by action of diethylzinc and methylene iodide. The reaction has been successfully applied to dialkyl and diaryl dithioketals, to spirocyclic analogs, and to a dithioacetal. A monothioketal produced a vinyl ether (enol ether) with the same reagent. 相似文献
5.
Popolohuanone-A (
) and B (
) are two new sponge metabolites of composition C42H57NO3. Their structures, which were determined by spectral and chemical correlations, comprise two molecules of a benzenoid moiety each linked to a rearranged drimane sesquiterpene and connected by an amino function. 相似文献
6.
Peter Baran Raphael G. Raptis Abimael D. Rodríguez Ileana I. Rodríguez Yan-Ping Shi 《Journal of chemical crystallography》2003,33(9):711-718
X-ray structures of Elisabatin B (1) and Elisabatin C (2) have been determined. Crystal data for 1: Triclinic, P
(No. 2), a = 7.528(2) Å, b = 9.404(2) Å, c = 11.414(2) Å, = 75.363(3)°, = 86.668(4)°, = 89.683(4)°, and Z = 2. Crystal data for 2: Monoclinic, P21/c (No. 14), a = 8.242(2) Å, b = 14.870(2) Å, c = 13.060(2) Å, = 101.458(3)°, and Z = 4. Both compounds are highly unsaturated leading to extended aromatic conjugation. They show different intermolecular O–HO hydrogen bonds, via which 1 forms dimers, and 2 zig-zag polymeric chains. 相似文献
7.
Jiang Zhu Abimael F. D. Loula Luigi Quartapelle 《Numerical Methods for Partial Differential Equations》2000,16(1):71-83
The vector Poisson equation is sometimes supplemented by conditions that include the specification of the boundary value of the divergence of the unknown. A rigorous analysis of such a vector Poisson problem and uncoupled solution methods have been presented for domains of C1,1 and Lipschitz regularity in [1] and [2], respectively. In this work, the finite element approximation of the two uncoupled solution methods is studied, and a convergence analysis of the numerical schemes is provided together with some numerical results. © 2000 John Wiley & Sons, Inc. Numer Methods Partial Differential Eq 16: 71–83, 2000 相似文献
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9.
A bidirectional affinity system was used to screen for marine natural products that bound to Escherichia coli proteins. A system was developed and applied to isolate the natural product sceptrin from an Agelas conifera extract and its affinity partner MreB from E. coli lysate. The use of a dual immunoaffinity fluorescent (IAF) tag permitted this process to co-immunoprecipitate the bacterial equivalent of actin, MreB, from E. coli lysate. MreB was subsequently validated as a target for sceptrin using a resistance mapping approach. The combination of these studies suggests that natural products and their protein targets can be isolated in concert using a melody of forward and reverse affinity matrices. While the structure of sceptrin was elucidated by NMR analysis, the bulk of effort was conducted without knowing the structure of the natural product, thereby elevating a key bottleneck in the development of high-throughput methods for natural product discovery. 相似文献
10.
Vera B Rodríguez AD La Clair JJ 《Angewandte Chemie (International ed. in English)》2011,50(35):8134-8138
A bidirectional affinity system has been developed for the identification of cancer-related natural products and their biological targets. Aplysqualenol A is thus selectively identified as a ligand of the dynein light chain. The use of forward and reverse affinity methods suggests that both small-molecule isolation and target identification can be conducted using conventional molecular biological methods. 相似文献