Very Simple One-Step Synthesis of Vinylphosphonates and Enamine Phosphonates by Direct Addition of Organolithium Reagents to 1-Alkynylphosphonates

Abstract

Direct addition of organolithium to 1-alkynylphosphonates (1) afforded vinylphosphonates and enamine phosphonates (2) in good to excellent yields. The reaction was carried out in dry THF at low temperature and proved to be completely stereoselective (syn addition). Alkyl, aryl, and haloalkyl groups were attached to the alkynyl entity, so the resulting vinylphosphonates contained various functional groups. The stereochemistry of the products as well as mechanism of the reaction were determined based on ¹H and ¹³C NMR. The synthesis of enamine phosphonates in the absence of complicated, highly expensive organometallic catalysis has not been previously reported.     

An updated review of nanofluids in various heat transfer devices

Journal of Thermal Analysis and Calorimetry - The field of nanofluids has received interesting attention since the concept of dispersing nanoscaled particles into a fluid was first introduced in...     

Direct one-step synthesis of azaheterocyclic phosphonates from diethyl ω-chloro-1-alkynylphosphonates and hydrazines

Hydrazines react with 4-, 5- and 6-chloro-1-alkynylphosphonates to provide the corresponding azaheterocyclic phosphonates in good yields and purity. The suggested mechanism consists of initial addition to the carbon-carbon triple bond to generate a zwitterionic species in which the amine is situated trans to the lone pair of the anion.     

New Thiophene Derivatives as Antimicrobial Agents

Phenacylbromide derivatives constitute a multilateral group of precursors for the synthesis of numerous heterocycles of organic compounds. Briefly, 5‐(2‐bromo‐acetyl)‐substituted‐thiophene derivative has been used as a synthon for synthesis of new thiophene‐containing compounds through the reaction with nucleophilic nitrogen compounds and thioamides. The suggested structures of the newly synthesized thiophene compounds were confirmed and assured with different spectroscopic tools and with CHN elemental analysis. Additionally, the antimicrobial activity of these thiophene compounds was recorded to investigate their potency against various types of bacteria and fungi. Results showed that these compounds exhibit significant inhibitory activity against the growth of tested bacterial and fungal strains and that some derivatives were more potent than the employed reference drugs.     

Heat transfer in circular microchannels during volumetric heating with magnetic field

Convective heat transfer within circular microchannels in a rectangular solid substrate with heat generation due to imposed magnetic field was studied. A detailed parametric study was performed by varying Reynolds number, magnetic field strength, working fluid, and the diameter of the channel. It was found that the heat transfer coefficient decreases downstream along the channel. Nusselt number increased with Reynolds number. The tube diameter, properties of the working fluid, and magnetic field strength affected the temperature distribution and heat transfer rate at the solid-fluid interface.     

Natural convection in inclined partitioned enclosures

The problem of steady, laminar, natural convective flow of a viscous fluid in an inclined enclosure with partitions is considered. Transverse gradient of temperature is applied on the two opposing regular walls of the inclined enclosure while the other walls are maintained adiabatic. The problem is formulated in terms of the vorticity-stream function procedure. A numerical solution based on the finite volume method is obtained. Representative results illustrating the effects of the enclosure inclination angle and the degree of irregularity on the contour maps of the streamlines and temperature are reported and discussed. In addition, results for the average Nusselt number at the heated wall of the enclosure and the difference of extreme stream-function values are presented and discussed for various Rayleigh numbers, inclination angles and dimensionless partition heights.     

Evaluation of a tube equipped with different inserts: competition between improvements in heat transfer versus increase in pressure drop

Journal of Thermal Analysis and Calorimetry - This study evaluated the efficacy of different inserts incorporation into the simple tube on the rate of improvement in heat transfer as well as the...     

LC method for the direct and simultaneous determination of four major furan derivatives in coffee grounds and brews

The simultaneous quantification of two potential genotoxic hydroxymethyl furan derivatives in coffee (furfuryl alcohol and 5‐hydroxymethylfurfural) alongside their carboxylic acid derivatives (2‐furoic acid and 5‐hydroxymethyl furoic acid, respectively) was carried out. Their extraction from ground roasted coffee using sonication, simple shaking or heat‐assisted shaking lead to similar results. A minimum of 97.3% of the four furan derivatives were extracted during the first extraction cycle using water, whereas methanol showed considerably lower extraction efficiency. A simple high‐performance liquid chromatography method coupled with diode array detection was developed for the simultaneous determination and was applied to roasted coffee extracts or brews. No sample pre‐treatment except for centrifugation was needed. The diode array detector was used to assess the purity of the peaks of interest in analyzed samples against authentic standards. The linearity according to Mandel, accuracy (recovery ≥ 89.9%) and precision (inter‐ and intraday relative standard deviation ≤ 4.5%) were checked. The values for the limit of detection and quantification ranged within 0.11–0.76 and 0.35–2.55 μg/mL, respectively. Filtered and espresso brews were analyzed for the four furan derivatives where furfuryl alcohol showed double the concentration of 5‐hydroxymethylfurfural and about ten times the concentrations of 2‐furoic acid or 5‐hydroxymethyl furoic acid.     

MHD mixed convection–radiation interaction along a permeable surface immersed in a porous medium in the presence of Soret and Dufour’s Effects

This work is focused on the numerical modeling of steady, laminar, heat and mass transfer by MHD mixed convection from a semi-infinite, isothermal, vertical and permeable surface immersed in a uniform porous medium in the presence of thermal radiation and Dufour and Soret effects. A mixed convection parameter for the entire range of free-forced-mixed convection is employed and the governing equations are transformed into non-similar equations. These equations are solved numerically by an efficient, implicit, iterative, finite-difference scheme. The obtained results are checked against previously published work on special cases of the problem and are found to be in excellent agreement. A parametric study illustrating the influence of the thermal radiation coefficient, magnetic field, porous medium inertia parameter, concentration to thermal buoyancy ratio, and the Dufour and Soret numbers on the fluid velocity, temperature and concentration as well as the local Nusselt and the Sherwood numbers is conducted. The obtained results are shown graphically and the physical aspects of the problem are discussed.     

Advanced Photoelectrochemical Hydrogen Generation by CdO-g-C3N4 in Aqueous Medium under Visible Light

Herein, hydrothermal fabrication of CdO-g-C₃N₄ photocatalyst for a substantially better photocatalytic recital in water splitting is presented. The XRD analysis confirms the cubic phase of CdO-g-C₃N₄, whereas FTIR and UV-VIS studies revealed the presence of respective groups and a median band gap energy (2.55 eV) of the photocatalyst, respectively, which further enhanced its photo-electrochemical (PEC) properties. The SEM displays the oblong structures of g-C₃N₄ sheets and nano rod-like morphology of CdO and CdO-g-C₃N₄, respectively. The HR-TEM exhibits morphology & orientation of the grains and substantiates the polycrystal-line nature of CdO-g-C₃N₄ nanocomposite. The photocatalytic water-splitting concert is evaluated by PEC experiments under 1 SUN visible light irradiation. Linear sweep voltammetry (LSV), chronoamperometry (CA), and electrochemical impedance spectroscopy (EIS) comprehend the CdO-g-C₃N₄ as a hydrogen evolution photocatalyst. A photocurrent density beyond ≥5 mA/cm² is recorded from CdO-g-C₃N₄, which is 5–6 folds greater than pure CdO and g-C₃N₄. The efficient separation and transfer of charges allocated to CdO-g-C₃N₄ and fabricating heterojunctions between g-C₃N₄ and CdO suppresses the unfavorable electron-hole pairs recombination process. Thus, it recesses charge transfer resistance, augmenting enhanced photocatalytic performance under 1 SUN irradiation.