Preparation and characterization of Co(II), Ni(II) and Cu(II) complexes of a ligand containing 1,3,4-thiadiazole groups

(1R,2R)-1,2-bis-(5-amino-1,3,4-thiadiazole-2-yl)ethane-1,2-diol (L) has been prepared by the reaction of thiosemicarbazide with (2R,3R)-(+)-tartaric acid (I) and phosphorous oxychloride, and its complexes with Co(II), Ni(II) and Cu(II) have been obtained. The structures of the ligand and its complexes have been established by i. r., ¹H- and ¹³C-n.m.r. spectra, u.v.–vis–nir spectroscopy, elemental analyses, T.g.-D.t.a. and magnetic susceptibility measurements.     

Anticancer activities of manganese-based photoactivatable CO-releasing complexes (PhotoCORMs) with benzimidazole derivative ligands

Carbon monoxide is an important signaling molecule which is produced by heme oxygenase-1. CO shows antiproliferative activity against cancer cells; hence, activation of HO-1 is a significant inhibition strategy against tumor formation and survival of cancer cells. In this work, manganese-based CO-releasing molecules (CORMs) were designed and synthesized to inhibit breast cancer cell proliferation. Human invasive ductal breast cancer cells (MCF-7) were treated with the synthesized CORMs to investigate the effect of the complexes on breast cancer survival under UV light. In vitro experiments indicated that the complexes inhibited breast cancer cell proliferation, and further, the antiproliferative effects were increased under UV light. Thus, these novel CORMs may provide a drug template for the treatment of invasive ductal breast cancer.     

Reference intervals of serum folate and vitamin B12 developed from data of healthy subjects

 In this study the reference intervals for folate and vitamin B₁₂ were estimated according to the National Committee for Clinical Laboratory Standards Approved Guideline C28-A and International Federation of Clinical Chemistry recommendations. The study included 155 women and 124 men between ages 18–40. The health status was confirmed by history, physical examination and a questionnaire. The central 95% reference intervals of serum folate and vitamin B12 for women, determined non-parametrically, were found to be 3.9–18.1 ng/ml and 101–666.7 pg/ml, respectively. The reference values of serum folate and vitamin B12 for men were also found to be 2,5–17.6 ng/ml and 100–699.57 pg/ml, respectively. We did not observe subclass differences between females and males. Received: 15 April 2000 · Accepted: 15 April 2000     

A practical analytical quality report on the effect of carotenemia on neonatal bilirubin levels

 The effect of haematocrit and β-carotene levels on the serum total bilirubin measurement in two analytical methods was studied as an example of the impact of practical analytical quality in medical decision making. The precision characteristics of the two methods were very similar. Based upon the significant difference in the correlation coefficient in a method comparison study before and after 20% trimming of the data, an interference effect study was performed. Haemoglobin (expressed as haematocrit) and β-carotene were the substances studied to explain the observed differences. The bilirubin test results from the Wako bilirubinometer were easily affected (n=19;X(S): 13.83±2.43;t=–6.17;P=0.000) and more elevated than in the Vitros dry chemistry systems (n=18;X(S): 12.72±2.21;t=–2.48;P=0.017), due to the presence of β-carotene (>200 μg/dl).     

The optical properties of a novel metal-free phthalocyanine

In the present work, 4-(4′-dodecyloxycarbonyl) phenoxy phthalonitrile was synthesized and then this phthalonitrile derivative was cyclotetramerized in dodecanol resulting a new metal-free phthalocyanine. The optical properties of this phthalocyanine were investigated. Novel metal-free phthalocyanine thin films were deposited on indium tin oxide-coated glass substrates by spinning method. Surface and microstructural properties of the films were characterized by atomic force microscopy and scanning electron microscopy. Both the transmittance and reflectance spectra of the deposited films were recorded using an NKD analyser. The optical band gap energy, the thickness of thin films, refractive index (n) and extinction coefficient (k) were calculated as 2.7 eV, 300 nm, 1.47 and 0.02, respectively.     

Synthesis,Spectroscopic Studies and Structure of 2-[(Benzo[<Emphasis Type="Italic">d</Emphasis>]thiazol-2-ylamino)methyl]phenol

Abstract  

Schiff base (E)-2-[(benzo[d]thiazol-2-ylimino)methyl]phenol (1) has been synthesized from the reaction of 2-hydroxy-benzaldehyde with 2-aminobenzothiazole. The 2-[(benzo[d]thiazol-2-ylamino)methyl]phenol (2) was prepared reduction of the Schiff base 1 with sodium borohydride. The compounds 1 and 2 have been characterized by elemental analysis, FT-IR, ¹H-NMR, ¹³C-NMR and UV–visible spectroscopic techniques. The structure of the compound 2 has also been examined crystallographically. The compound 2 crystallizes in the monoclinic space group P2/c. The unit cell parameters were found as a = 10.017(1), b = 11.725(1), c = 10.341(1) ?, V = 1208.1(1) ?³, D _x = 1.409 g cm⁻³ and Z = 4. The crystal structure was solved by direct methods and refined by the full-matrix least squares method and found as R ₁ = 0.0308 and wR ₂ = 0.0818 for 2032 for the observed reflections [I > 2σ(I)].     

Schwarzian derivative as a proof of the chaotic behaviour

In recent years, a sufficient condition for determining chaotic behaviours of the non-linear systems has been characterized by the negative Schwarzian derivative (Hac?bekiro?lu et al, Nonlinear Anal.: Real World Appl. 10, 1270 (2009)). In this work, the Schwarzian derivative has been calculated for investigating the quantum chaotic transition points in the high-temperature superconducting frame of reference, which is known as a nonlinear dynamical system that displays some macroscopic quantum effects. In our previous works, two quantum chaotic transition points of the critical transition temperature, T _c, and paramagnetic Meissner transition temperature, T _PME, have been phenomenologically predicted for the mercury-based high-temperature superconductors (Onba?l? et al, Chaos, Solitons and Fractals 42, 1980 (2009); Aslan et al, J. Phys.: Conf. Ser. 153, 012002 (2009); Çataltepe, Superconductor (Sciyo Company, India, 2010)). The T _c, at which the one-dimensional global gauge symmetry is spontaneously broken, refers to the second-order phase transition, whereas the T _PME, at which time reversal symmetry is broken, indicates the change in the direction of orbital current in the system (Onba?l? et al, Chaos, Solitons and Fractals 42, 1980 (2009)). In this context, the chaotic behaviour of the mercury-based high-temperature superconductors has been investigated by means of the Schwarzian derivative of the magnetic moment versus temperature. In all calculations, the Schwarzian derivatives have been found to be negative at both T _c and T _PME which are in agreement with the chaotic behaviour of the system.     

A Parametric 1-Maximin Location Problem

We introduce a version of the weighted 1-maximin problem in a convex polygon, where the weights are functions of a parameter. The 1-maximin problem is applicable in the location of undesirable facilities. Its objective is to find an optimal location such that the minimum weighted distance to a given set of points is maximized. We show that the parametric 1-maximin problem is equivalent to a 1-minimax problem, where the costs are non-linearly decreasing functions of distance. Using different values of the parameter in the 1-maximin problem, one can model different disutility functions for the users of the facility. Furthermore, the parameterization provides for a systematic way of reducing the effects of the weights, resulting in the unweighted 1-maximin problem in the limit. For two example problems we construct the optimal trajectory as a function of the parameter, and demonstrate that the trajectory may be discontinuous.