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Development of an LC‐MS/MS method for determining the pharmacokinetics of clonidine following oral administration of Zhenju antihypertensive compound
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Jing Qin Limin Wang Lihong Wu Jun Chen Teng Shen Yongji Li Limei Han Jianxin Wang 《Biomedical chromatography : BMC》2015,29(7):1068-1075
Zhenju antihypertensive compound (ZJAHC) is a combined Chinese–Western medicine formula including clonidine (CLO), hydrochlorothiazide (HCT), rutin, Chrysanthemum indicum extract and pearl powder. Compared with CLO preparations, ZJAHC shows improved activities and decreased adverse effects. It is believed that the side effects of CLO are caused by its high peak plasma concentration. Hence, study of the influence of ZJAHC on the pharmacokinetic behaviors of clonidine seems essential. In present study, the plasma concentrations of CLO were determined with a liquid chromatography–tandem mass spectrometry (LC‐MS/MS) method. The MS/MS transitions monitored for clonidine and internal standard were 230.2 → 213.1 and 152.2 → 110.2, respectively. The analyte was quantified in a single run within 3 min. The pharmacokinetic study showed that the area under the plasma concentration–time curve of CLO in ZJAHC (60 µg/kg CLO) was similar to that of CLO‐HCT‐high (120 µg/kg CLO) but the peak concentration was much lower than that in CLO‐HCT‐high. ZJAHC could enhance the bioavailability without greatly increasing peak concentration of clonidine. This comprehensive effect of enhancing the bioavailability and avoiding the high peak plasma concentration for CLO might mainly result from the co‐contribution of Western medicine and traditional Chinese medicine (TCM), while the effect of TCM was stronger than that of Western medicine. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
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F. R. Ling B. Wang T. Geng S. Q. Fang W. Yuan D. D. Teng C. X. Guan 《Optics & Laser Technology》2004,36(7):541-544
In this paper experimental studies of nonvolatile photorefractive holographic recording in Ce:Cu:LiNbO3 crystals doped with Sc(0,1,2,3 mol%) were carried out. The Sc:Ce:Cu:LiNbO3 crystals were grown by the Czochralski method and oxidized in Nb2O5 powders. The nonvolatile holographic recording in Sc:Ce:Cu:LiNbO3 crystals was realized by the two-photon fixed method. We found that the recording time of Sc:Ce:Cu:LiNbO3 crystal became shorter with the increase of Sc doping concentration, especially doping with Sc(3 mol%), which exceeds the so-called threshold, and there was little loss of nonvolatile diffraction efficiencies between Sc(3 mol%):Ce:Cu:LiNbO3 and Ce:Cu:LiNbO3 crystals. 相似文献
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曙光一号自由电子激光器的理论计算 总被引:1,自引:0,他引:1
系统总结曙光一号自由电子激光器理论计算的主要结果:包括曙光一号装置主要参数的选取和理解;磁场失谐曲线的计算;常参数摇摆器和变参数摇摆器的主要结果;高阶波导模的贡献;电子束参数扰动对激光性能的影响;空间电荷效应等。计算结果表明,常参数摇摆器激光输出功率可达80MW,效率约50%;变参数摇摆器激光输出功率可达250MW左右,效率约16%。 相似文献
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The possible defect models of Y^3+:PbWO4 crystals are discussed by defect chemistry and the most possible substituting positions of the impurity Y^3+ ions are studied by using the general utility lattice program (GULP). The calculated results indicate that in the lightly doped Y^3+ :PWO crystal, the main compensating mechanism is [2Ypb^+ + VPb^2-], and in the heavily doped Y^3+ :PWO crystal, it will bring interstitial oxygen ions to compensate the positive electricity caused by YPb^+, forming defect clusters of [2Ypb^+ +Oi^2-] in the crystal. The electronic structures of Y3+ :PWO with different defect models are calculated using the DV-Xα method. It can be concluded from the electronic structures that, for lightly doped cases, the energy gap of the crystal would be broadened and the 420nm absorption band will be restricted; for heavily doped cases, because of the existence of interstitial oxygen ions, it can bring a new absorption band and reduce the radiation hardness of the crystal. 相似文献
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苝二酸酐与嘧啶衍生物的氢键组装 总被引:1,自引:0,他引:1
用半经验AM1方法对苝二酸酐与嘧啶衍生物的1:1及1:2氢键复合物进行理论研究,表明随着氢键数目增多,弱相互作用能变大,主体上的供电基和客体上的吸电基有利于氢键相互作用,氢键导致电子从主体流向客体.用INDO/SCI方法计算配合物的电子光谱,表明其长波吸收峰与主体相比发生兰移,各配合物的长波吸收峰位置相差不大,与实验一致.讨论吸收峰兰移的原因并对电子跃迁进行理论指认,同时得到了配合物的双质子转移势能曲线,给出了相对于N-H键的过渡态和活化能. 相似文献
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实验获得了Ar+激光514.5nm线诱导23Na39K分子产生的D1∏→X1∑+跃迁荧光谱.通过测量激光感生荧光光谱强度随泵浦功率、热管炉温度及缓冲气压变化规律,详细研究了其跃迁机制.用最小二乘法拟合获得23Na39K分于X1∑+态振动常数.理论计算了各跃迁谱支波长值及Franck-Condon因子和光谱强度值,与实验观测值符合得相当好,充分表明本文对激光感生荧光光谱的归属以及对各支谱线振、转量子数的赋值是合理的. 相似文献