排序方式: 共有1条查询结果,搜索用时 0 毫秒
1
1.
Li ZhaoBo Wang JianGuang Chen JingRong Lei WanHua Wang XueSong Zhang BaoWen 《中国科学:化学(英文版)》2010,53(9):1994-1999
pH-responsive 1O2 photosensitizing systems may serve as selective photodynamic therapy (PDT) agents by targeting the acidic interstitial fluid of many kinds of tumors. In this work, a natural and clinically used photosensitizer (Hypocrellin B, HB) and a pH indicator (Bromocresol Purple, BCP) were co-encapsulated in organically modified silica nanoparticles. BCP successfully regulated the 1O2 generation efficiency of HB through the “inner filter” effect, which shows much stronger 1O2 generation ability in an acidic than in a basic environment. In vitro experiments also demonstrated that HB-doped nanoparticles are effective in killing tumor cells by PDT.
相似文献
1