Highly functionalized pyranopyrazoles: synthesis,antimicrobial activity,simulation studies and their structure activity relationships (SARs)

Research on Chemical Intermediates - Development of potent antibacterial and antifungal agents is a permanently new and unremitting investigation in the therapeutic field. Still, medicinal research...     

Microwave‐Assisted Synthesis of N‐Substituted Maleimide Derivatives as Exogenous Antioxidant Agents

A series of N‐substituted maleimide derivatives have been developed via acetic acid‐mediated microwave reaction pathway, which was identified as the incomparable method for this maleimide compounds. All the synthesized compounds were tested for antioxidant activity by DPPH and H₂O₂ methods. Compounds 5h and 5m were displayed with higher antioxidant activity in two methods. The structure–activity relationship demonstrated that the compounds having electron releasing substitutions 5h and 5m generally show beneficial activity than electron capture substitution cores. Thus, compounds 5h and 5m may be useful as an exogenous antioxidant.     

Design,synthesis of tri-substituted pyrazole derivatives as promising antimicrobial agents and investigation of structure activity relationships

The major diseases spread in the environment only because of microbes. Even, intensive care units in the hospitals are polluted by microorganisms, particularly, Gram-positive bacteria. Although many antibiotics are existed, there is a need to develop up to date microbial-resistant agents. Hence, the current study aimed to develop prominent antimicrobial drug-related compounds. Thus, a novel series of tri-substituted analogs and their intermediates were synthesized. In addition, total new compounds were screened for their antimicrobial assay and identified as the most efficient biologically active compounds. Moreover, minimal inhibitory antimicrobial activity and appropriate structure activity relationships were investigated. From the results it was observed that, viability of Gram-positive bacteria was most powerfully affected by all active compounds. Finally, this research demonstrated that, these biologically energetic amalgams can be utilized for further preclinical studies with the ambition of standing unique inventive drugs.     

General Theoretical Model for Resonantly Enhanced Optical Modulators

1 Introduction LiNbOoptical modulators have become essential transmission devices for current and future wideband bre-optic communications for both military and telecommunications applications. For many telecommunications applications,only a narrow bandwidth is required and thus resonantly enhancedMach-Zehndermodulators(RE-MZMs)[1]have been developed to improve modulation ef ciency at theexpense of bandwidth.     

An Efficient One‐Pot,Multicomponent, and Green Solvent Protocol for the Synthesis of Dihydropyridine Derivatives

Highly prominent dihydropyridine analogs have been developed and screened for their yields by using different catalysts under eco‐friendly ethanol solvent condition. Triethylamine catalyst was identified as ro bust catalyst for this synthetic path. The key benefits of this procedure are environmentally benign procedure, mild reaction conditions, simplicity of operation, high yields, mild reaction period, and decent substrate generality.     

An efficient and green approach: One pot,multi component,reusable catalyzed synthesis of pyranopyrazoles and investigation of biological assays

An ecofriendly itinerary for the synthesis of pyranopyrazole derivatives having thioether link has been established via reusable, green catalyst, green solvent and multicomponent domino approach. To avoid impurities, usage of toxic solvents, toxic catalyst, simple workup and quantitative yields were strategies of this method. In addition, all the reported compounds were tested for their antioxidant and antibacterial properties. Some compounds displayed higher antioxidant activity than the standard drug (6a and 6j), while some other active compounds showed prominent antibacterial activity (6e and 6n). The results demonstrated that these active compounds may be used to support as a decent stand for further investigation in a way to ascertain innovative antioxidant and antibacterial medicines.