Urea Detection of Electrochemical Transistor Sensors based on Polyanline (PANI)/MWCNT/Cotton Yarns

A cotton yarn biosensor based on electrochemical transistor functionalized with MWCNT and PANI was developed for the detection of urea. The transistors based on PANI/MWCNT/cotton yarns under optimized MWCNT concentration has been obtained, which exhibited high on/off current ratio, fast response time, and good operational stability. A transistor-based urea sensor was prepared from PANI/MWCNT/cotton yarns, which could monitor urea in the 1 nM–1 mM linear range with the correlation coefficient of 0.9716. Furthermore, the sensor showed superior reproducibility and high specificity. The practical applications of the proposed sensor were also confirmed. These results indicate the flexible transistor can be used as an efficient platform for biological detection in body fluids.     

Rational Design of Selenadiazole Derivatives to Antagonize Hyperglycemia‐Induced Drug Resistance in Cancer Cells

Hyperglycemia is an important factor for chemoresistance of hepatocellular carcinoma patients with diabetes to therapeutics. In the present study, a series of selenadiazole derivatives have been rationally designed, synthesized, and found be able to antagonize drug resistance in HepG2 cells to doxorubicin (DOX) under simulated diabetes conditions. Hyperglycemia could promote the cell proliferation through upregulation of ERK and AKT phosphorylation. However, the synthetic selenadiazole derivatives effectively potentiated the cellular uptake of DOX and enhanced the antiproliferative activity of DOX on HepG2 cells by induction of apoptosis, via regulation of ROS‐mediated AMPK activation, inhibition of mTORC1, and an increase in DNA damage. The selenadiazole derivatives that possess an increased lipophilicity could enhance the cellular uptake and anticancer efficacy of DOX. Taken together, this study provides a rational design strategy of selenadiazole derivatives to overcome hyperglycemia‐induced drug resistance.     

Polypyrrole modified hierarchical porous CoS2@RGO aerogel electrode for ultrafast sodium storage

Journal of Solid State Electrochemistry - CoS2 nanooctahedrons homogeneously encapsulated by hierarchical porous-reduced graphene oxide and polypyrrole thin film are constructed via a simple...