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CM Silva MF Duarte ML Mira MH Florêncio K Versluis AJ Heck 《Rapid communications in mass spectrometry : RCM》1999,13(12):1098-1103
Fast atom bombardment, combined with high-energy collision-induced tandem mass spectrometry, has been used to investigate gas-phase metal-ion interactions with captopril, enalaprilat and lisinopril, all angiotensin-converting enzyme inhibitors.Suggestions for the location of metal-binding sites are presented. For captopril, metal binding occurs most likely at both the sulphur and the nitrogen atom. For enalaprilat and lisinopril, binding preferably occurs at the amine nitrogen. Copyright 1999 John Wiley & Sons, Ltd. 相似文献
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Enyenihi AA Yang H Ytterberg AJ Lyutvinskiy Y Zubarev RA 《Journal of the American Society for Mass Spectrometry》2011,22(10):1763-1770
His64 and His93 are the two well-known sites of heme binding in water-dissolved holo-myoglobin, with His93 being a proximal,
strongly binding partner, while the distal His64 weakly coordinates to the heme through a small-molecule ligand, e.g., water
or O2. The heme bonding scheme in a water-free environment is as yet unclear. Here we employed electron transfer dissociation tandem
mass spectrometry to study the preferential attachment site of the ferri-heme (Fe3+) in electrospray-produced 12+, 14+, and 16+ holo-myoglobin ions. Contrary to expectations, in lower-charge complexes that
should have a structure resembling that in solution, the heme seems to be preferentially attached to the “distal” histidine.
In contrast, in the highest studied charge state, the “proximal” histidine is the site of preferential attachment; the 14+
charge state is an intermediate case. This surprising finding raises a question of heme coordination in proteins transferred
to water-free environment, as well as the effect of the protonation sites on heme bonding. 相似文献
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A procedure is explained to determined the amount of several pairs of diametrical loads applied to the outside boundary of
a ring when stresses at selected points of the inside or outside boundaries are known. Coefficients of influence are used,
following an approach similar to the one presented in a previous paper. Examples of application are given and the possible
increase in precision is shown when the number of points of measurements is larger than the number of loads to be determined. 相似文献
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