Enantioseparation of three kinds of adrenaline by capillary electrophoresis using Ser-AuNPs as chiral selectorEI北大核心CSCD

Au nanoparticlesAuNPswere synthesized by chemical reduction methodand its surface was chiral modified with serine to prepare Ser-AuNPs. The synthesis effect and particle size distribution of AuNPs and Ser-AuNPs were characterized by UV-Vis spectrophotometry and laser particle size analyzer. The Ser-AuNPs was used as a chiral selector for the enantiomeric separation of three adrenaline drugs by capillary zone electrophoresis. The influences of the binding concentration of serinebuffer pHseparation voltage and capillary temperature on the enantioseparation were investigated. The results showed that the enantiomeric separation of isoprenaline adrenaline and noradrenaline could achieve baseline separation at the optimal separation conditions. The corresponding resolutions were 3.192.85 and 3.77 for isoprenalineadrenaline and noradrenalinerespectively. And this method possessed good reproducibility and precision. © 2022, Youke Publishing Co.,Ltd. All rights reserved.