La（Ⅲ）、Nd（Ⅲ）与甜菜碱类衍生物形成的包含（H2O）6分子簇的配合物的晶体结构

利用配体1,5-二（3-羧基吡啶基）-N-甲基二乙胺（L）合成2种稀土金属配合物{[La₂L₄（H₂O）₂]（ClO₄）₆·6H₂O}_n（1）和[Nd₂L₄（DMF）₆（H₂O）₂]₂（ClO₄）₆·4H₂O（2）。用红外光谱和X-射线单晶衍射表征配合物的晶体结构。结构分析表明：配合物1属于三斜晶系,P1空间群,其晶胞参数为a=1.4966（3）nm,b=1.5597（4）nm,c=1.9568（4）nm,α=86.776（6）°,β=77.723（7）°,γ=87.168（7）°,Z=2。在配合物1中,一对La（Ⅲ）原子被2个羧基桥联,形成双核结构;双核结构进一步被羧基连接,从而形成平行于c轴的一维链。值得注意的是配合物1的晶体结构中包含着由氢键连接的6个H₂O分子组成的水分子簇。配合物2属于三斜晶系,P1空间群,晶胞参数为a=1.0408（4）nm,b=1.3541（5）nm,c=2.975（1）nm,α=94.390（8）°,β=91.720（7）°,γ=95.230（4）°,Z=2。配合物2中4个羧基连接一对Nd（Ⅲ）原子,形成四轮状结构,其中2个羧基采取syn-syn双原子桥联模式,而其余2个羧基则采取单原子桥联模式。     

La（Ⅲ）、Nd（Ⅲ）与甜菜碱类衍生物形成的包含（H2O）6分子簇的配合物的晶体结构

利用配体1,5-二(3-羧基吡啶基)-N-甲基二乙胺(L)合成2种稀土金属配合物{[La2L4(H2O)2](ClO4)6·6H2O}n(1)和[Nd2L4(DMF)6(H2O)2]2(ClO4)6·4H2O(2)。用红外光谱和X-射线单晶衍射表征配合物的晶体结构。结构分析表明:配合物1属于三斜晶系,P1空间群,其晶胞参数为a=1.496 6(3)nm,b=1.559 7(4)nm,c=1.956 8(4)nm,α=86.776(6)°,β=77.723(7)°,γ=87.168(7)°,Z=2。在配合物1中,一对La髥原子被2个羧基桥联,形成双核结构;双核结构进一步被羧基连接,从而形成平行于c轴的一维链。值得注意的是配合物1的晶体结构中包含着由氢键连接的6个H2O分子组成的水分子簇。配合物2属于三斜晶系,P1空间群,晶胞参数为a=1.040 8(4)nm,b=1.354 1(5)nm,c=2.975(1)nm,α=94.390(8)°,β=91.720(7)°,γ=95.230(4)°,Z=2。配合物2中4个羧基连接一对Nd髥原子,形成四轮状结构,其中2个羧基采取syn-syn双原子桥联模式,而其余2个羧基则采取单原子桥联模式。     

Al2O3/SnO2 Co-Nanoparticle Modified Grafted Collagen for Improving Thermal Stability and Infrared Emissivity

Al2O3/SnO2 co-nanoparticles were prepared with a modified sol-gel technique followed by a thermal treatment process. With these co-nanoparticles the grafted collagen-Al2O3/SnO2 nanocomposites were obtained using a supersonic dispersion method. X-ray diffraction, FT-IR analysis, transmission electron microscopy, TGA/DTA and infrared emissivity test were performed to characterize the resulting nanoparticles and nanocomposites, respectively. The Al2O3/SnO2 co-nanoparticles showed a narrow distribution of size between 20-40 nm and could be uniformly absorbed on the tri-helix scaffolds of the grafted collagen without any aggregation. The nanocomposites possessed better thermal stability and substantially lower infrared emissivity than the grafted collagen and Al2O3/SnO2 co-nanoparticles with an increase of degradation temperature from 39 to 210 ℃ and a decrease of infrared emissivity from 0.850 of the grafted collagen and 0.708 of the Al2O3/SnO2 co-nanoparticles to 0.424, which provided a potential application of the nanocomposites to areas such as photoelectronics.     

Simultaneous Quantification of Puerarin and Daidzein in Rat Plasma by High-Performance Liquid Chromatography with Post-Column Modification and Fluorescence Detection

A sensitive HPLC method based on post-column modification and fluorescence detection has been developed for determination of puerarin and daidzein in rat plasma. Chromatographic separation was performed on a C₈ column with a linear gradient prepared from 0.5% aqueous acetic acid and 0.5% acetic acid in acetonitrile, delivered at a flow rate of 0.8 mL min⁻¹. Naringin was used as the internal standard. It was necessary to use acetic acid in the mobile phase to achieve good separation, but this led to fluorescence signal suppression, because puerarin and daidzein have native fluorescence at pH 8.0–9.0. To enhance the sensitivity, post-column modification with alkaline buffer was adopted. After this modification, detection sensitivity for puerarin and daizein increased more than 500-fold and 600-fold, respectively, compared with direct fluorescence detection. Signal-to-noise ratios for detection for puerarin were more than 150 times better than for UV detection after use of the same method of sample preparation. This sensitive analytical method was successfully used to determine pharmacokinetic data for puerarin and daidzein in rat plasma after oral administration of a single dose of Puerariae radix extract containing puerarin (approx. 8.4 mg) and daizein (approx. 5.9 mg) to male SD rats.     

Co(Ⅱ)与甜菜碱类衍生物形成的两种配合物的结构和磁性特征

合成了2种新的Co(Ⅱ)的配合物{[Co(L1)₂(H₂O)₂](ClO₄)₂·4H₂O}_n(1)和{[Co(L2)₂(H₂O)₄](ClO₄)₂·8H₂O·L2}_n(2)(L1=1,1'-(4,4'-二亚甲基联苯)二(1-吡啶鎓-3-羧酸盐),L2=1,1'-(4,4'-二亚甲基联苯)二(1-吡啶鎓-4-羧酸盐)),并且分别用红外光谱、热差分析、X射线粉末衍射和X射线单晶衍射表征了这两种化合物。晶体结构分析表明L1,L2,1和2分别属于P2₁/c,P2₁/c,P1和P1空间群。化合物1为二维的配位聚合物,2为单核配合物。二者的晶体结构都含有大量的氢键作用或者配位键形成的孔状结构。此外,磁性研究表明,1和2中都存在反铁磁性相互作用。     

Studies of the Synergistic Actions of Three Herbs in Tong-Mai Formula

Tong-Mai oral liquid, containing three herbs (Pueraria radix, radix Salviae miltiorrhizae and rhizoma Chuanxiong), is a formula created under the theory of traditional Chinese medicine (TCM) to invigorate the ‘blood’ and dispel ‘blood stasis’, which arises from poor blood circulation. In Tong-Mai formula, Pueraria radix is used for improved blood circulation and to treat cardiovascular diseases and arrhythmia. Radix Salviae miltiorrhizae was widely used in TCMs for treatment of coronary heart disease, blood circulation diseases, and other cardiovascular diseases; rhizoma Chuanxiong is used to treat thrombosis and platelet aggregation. Clinically, combining the use of these herbs was therapeutically valuable, which suggests that they might synergistically prevent thrombosis. In this study, the pharmacokinetic behaviors of puerarin and daidzein in rat plasma were studied after orally administrated to four kinds of extracts. Puerarin and daidzein were set as index components. In the Tong-Mai oral liquid group, puerarin and daidzein showed the maximum plasma concentration and the lowest clearance rate of plasma. The results indicated that the herbal constituents in Tong-Mai formula showed synergism, and it may be helpful to certificate the rationality of the matching in Tong-Mai formula.

     

一种不含β-氢的苯并噁嗪的表征分析及催化固化研究

以邻烯丙基双酚A、多聚甲醛和烯丙基胺为原料，采用无溶剂的方法合成了一种不含β-氢的苯并噁嗪(2，2-二(3，8-二烯丙基-3，4-二氢-2H-1，3-苯并噁嗪)-丙烷(B—dbo)．GPC和元素分析结果表明，此噁嗪中间体主要是单量体和二聚体．用FTIR和^1H NMR对中间体结构进行了表征．结果表明，此苯并噁嗪的分子结构中存在三种反应官能团：噁嗪环、N-烯丙基、Ar-烯丙基．用DSC和FTIR研究三种反应基团在固化时的反应情况．将双酚A、邻烯丙基双酚A、TiCl4和PCl5作为催化剂按适量的比例加入B—dbo中，用DSC研究其固化行为，并对TiCl4催化试样在不同的固化温度下进行FTIR测试分析，提出在TiCl4催化下苯并噁嗪环副反应及开环固化机理．     

Charged-current non-standard neutrino interactions at the LHC and HL-LHC

A series of new physics scenarios predict the existence of the extra charged gauge boson \begin{document}$ W' $\end{document}, which can induce charged-current (CC) non-standard neutrino interactions (NSIs). The theoretical constraints on the simplified \begin{document}$ W' $\end{document} model and further on the CC NSI parameters \begin{document}$ \widetilde{\epsilon}^{ qq'Y}_{\alpha\beta} $\end{document} from partial wave unitarity and \begin{document}$ W' $\end{document} decays are considered. The sensitivity of the process \begin{document}$ p p \rightarrow W'\rightarrow \ell\nu $\end{document} to the \begin{document}$ W' $\end{document} model at the LHC and high-luminosity (HL) LHC experiments is investigated by estimating the expected constraints on \begin{document}$ \widetilde{\epsilon}^{qq'Y}_{\alpha\beta} $\end{document} (\begin{document}$ \alpha = \beta = e $\end{document} or μ) using a Monte-Carlo (MC) simulation. We find that the interference effect plays an important role, and the LHC can strongly constrain \begin{document}$ \widetilde{\epsilon}^{qq'L}_{\alpha\beta} $\end{document}. Compared with those at the \begin{document}$ 13 \;{\rm TeV} $\end{document} LHC with \begin{document}$ {\cal{L}}=139\;{\rm fb}^{-1} $\end{document}, the expected constraints at the \begin{document}$ 14 \;{\rm TeV} $\end{document} LHC with \begin{document}$ {\cal{L}}=3\;{\rm ab}^{-1} $\end{document} can be strengthened to approximately one order of magnitude.     

Co(Ⅱ)与甜菜碱类衍生物形成的两种配合物的结构和磁性特征

合成了2种新的Co(Ⅱ)的配合物{[Co(L1)2(H2O)2](Cl O4)2·4H2O}n(1)和{[Co(L2)2(H2O)4](Cl O4)2·8H2O·L2}n(2)(L1=1,1′-(4,4′-二亚甲基联苯)二(1-吡啶鎓-3-羧酸盐),L2=1,1′-(4,4′-二亚甲基联苯)二(1-吡啶鎓-4-羧酸盐)),并且分别用红外光谱、热差分析、X射线粉末衍射和X射线单晶衍射表征了这两种化合物。晶体结构分析表明L1,L2,1和2分别属于P21/c,P21/c,P1和P1空间群。化合物1中的Co(Ⅱ)与L1配位形成二维的配位聚合物,2中的Co(Ⅱ)与L2配位形成独立的阳离子。二者的晶体结构都含有大量的氢键作用或者配位键形成的孔状结构。此外,磁性研究表明,1和2中都存在反铁磁性相互作用。